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Relationship between dyslipidemia and albuminuria in prediabetic adults: The Korea National Health and Nutrition Examination Survey 2011–2012

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Abstract

This study aimed to estimate the relationship between various lipid abnormalities and albuminuria in Korean prediabetic adults. Data obtained from the Korea National Health and Nutrition Examination Survey (KNHANES) 2011–2012 were analyzed. The study consisted of 4,811 subjects in the normal glucose group and 3,872 in the prediabetic group. Prediabetes was defined by the fasting plasma glucose or hemoglobin A1c level. Albuminuria was defined as a urine albumin to creatinine ratio (UACR) ≥30 mg/g. Various parameters of dyslipidemia were assessed. No differences were observed in the prevalence of lipid abnormalities in prediabetic men with different values of UACR. Prediabetic women with increased urinary albumin excretion showed a significantly higher prevalence of lipid abnormalities. The proportion of mixed dyslipidemia was significantly higher in prediabetic women with albuminuria. Higher levels of total cholesterol, triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and TC to HDL-C ratio, TG to HDL-C ratio, and LDL-C to HDL-C ratio were significantly associated with increased risk of albuminuria in prediabetic women. Conclusions: Several lipid abnormalities were significantly associated with the increased risk of albuminuria in prediabetic women. Hence, screening for lipid abnormalities may be helpful for identification of risk for albuminuria in prediabetic subjects.

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Acknowledgments

We greatly appreciate the participants in the Korea National Health and Nutrition Examination Survey 2011-2012.

Conflict of interest

The authors declare that they have no conflict of interest or funding source.

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Authors and Affiliations

  1. Department of Family Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan-Si, Republic of Korea

    Ga Eun Nam, Do Hoon Kim, Yeo Joon Yoon, Young Eun Kim, Sangsu Lee & Sungho Lee

  2. Department of Biostatistics, Catholic University College of Medicine, Seoul, Republic of Korea

    Kyungdo Han & Yong Gyu Park

  3. Department of Family Medicine, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, 948-1 Daelim-dong, Youngdungpo-Gu, Seoul, 150-071, Republic of Korea

    Yong Kyun Roh

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  1. Ga Eun Nam
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Nam, G.E., Han, K., Kim, D.H. et al. Relationship between dyslipidemia and albuminuria in prediabetic adults: The Korea National Health and Nutrition Examination Survey 2011–2012. Endocrine 48, 557–565 (2015). https://doi.org/10.1007/s12020-014-0411-y

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