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Metabolic syndrome and endometrial cancer: a meta-analysis

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Abstract

We performed a systematic review and meta-analysis on the association of metabolic syndrome with endometrial cancer. A systematic literature search of electronic databases (Medline, ISI Web of Knowledge and Scopus) was conducted and complemented by cross-referencing to identify studies published before 31 January 2013. Core items of identified studies were independently extracted by two reviewers, and results were summarized by random effects meta-analysis. We identified six studies, which reported on 3,132 cancer cases. Metabolic syndrome was associated with an increased risk of endometrial cancer (RR: 1.89, 95 % CI 1.34–2.67, P < 0.001), with significant heterogeneity among studies (I 2 = 92 %, P < 0.001), but no indication for publication bias in the Egger’s test (P = 0.240). A sensitivity analysis omitting two studies produced no heterogeneity (I 2 = 0 %) and attenuated the association (RR: 1.39, 1.31–1.48, P < 0.001). The risk estimates for any single factor of the syndrome were 2.21 (P < 0.001) for higher values of body mass index and/or waist, 1.81 (P = 0.044) for hyperglycemia, 1.81 (P = 0.024) for higher blood pressure values, and 1.17 (P < 0.001) for high triglyceride levels; there was no significant association with low HDL-cholesterol. Metabolic syndrome is associated with an increased risk of endometrial cancer; among the components of the syndrome, obesity/high waist is that more strongly associated with endometrial cancer.

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Authors and Affiliations

  1. Department of Medicine and Public Health, Second University of Naples, Naples, Italy

    Paolo Chiodini

  2. Department of Experimental Medicine, Second University of Naples, Naples, Italy

    Annalisa Capuano

  3. Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Second University of Naples, Naples, Italy

    Giuseppe Bellastella, Maria Ida Maiorino & Dario Giugliano

  4. Division of Endocrinology, Diabetes, and Metabolic Diseases, Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Piazza L. Miraglia 2, 80138, Naples, Italy

    Katherine Esposito

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Esposito, K., Chiodini, P., Capuano, A. et al. Metabolic syndrome and endometrial cancer: a meta-analysis. Endocrine 45, 28–36 (2014). https://doi.org/10.1007/s12020-013-9973-3

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