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Gelatin Methacrylate (GelMA)-Based Hydrogels for Cell Transplantation: an Effective Strategy for Tissue Engineering

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Abstract

Gelatin methacrylate (GelMA)-based hydrogels are gaining a great deal of attention as potentially implantable materials in tissue engineering applications because of their biofunctionality and mechanical tenability. Since different natural tissues respond differently to mechanical stresses, an ideal implanted material would closely match the mechanical properties of the target tissue. In this regard, applications employing GelMA hydrogels are currently limited by the low mechanical strength and biocompatibility of GelMA. Therefore, this review focuses on modifications made to GelMA hydrogels to make them more suitable for tissue engineering applications. A large number of reports detail rational synthetic processes for GelMA or describe the incorporation of various biomaterials into GelMA hydrogels to tune their various properties, e.g., physical strength, chemical properties, conductivity, and porosity, and to promote cell loading and accelerate tissue repair. A novel strategy for repairing tissue injuries, based on the transplantation of cell-loaded GelMA scaffolds, is examined and its advantages and challenges are summarized. GelMA-cell combinations play a critical and pioneering role in this process and could potentially accelerate the development of clinically relevant applications.

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Acknowledgments

This research was financially supported by the National Natural Science Foundation of China (Grant Nos. 81401011, 81572229, 81673777), the Natural Science Foundation of Zhejiang, China (Grant No.LY15H060004).

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  1. Shining Xiao and Tengfei Zhao contributed equally to this work.

Authors and Affiliations

  1. Department of Orthopedic Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China

    Shining Xiao, Tengfei Zhao, Jingkai Wang, Chenggui Wang, Jiangnan Du, Liwei Ying, Caihua Zhang, Wanglu Hu & Kan Xu

  2. Zhejiang University-University of Edinburgh Institute, Zhejiang University, Zhejiang, 310058, Hangzhou, China

    Jiangtao Lin

  3. Department of Basic Medicine Sciences, School of Medicine, Zhejiang University, Hangzhou, 310058, China

    Linlin Wang

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  1. Shining Xiao
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Xiao, S., Zhao, T., Wang, J. et al. Gelatin Methacrylate (GelMA)-Based Hydrogels for Cell Transplantation: an Effective Strategy for Tissue Engineering. Stem Cell Rev and Rep 15, 664–679 (2019). https://doi.org/10.1007/s12015-019-09893-4

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