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Tocopherol Moderately Induces the Expressions of Some Human Sulfotransferases, which are Activated by Oxidative Stress

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Abstract

Oxidative stress is generated in biological system by several endogenous/exogenous factors like environmental-pollution/toxicity/diseases and by daily-life-stress. We previously showed that oxidative-stress impaired the activities/expressions of phase-II drug-metabolizing enzyme, sulfotransferases (SULTs). The SULT catalyzes sulfation of endogenous/exogenous compounds. Vitamin E is globally consumed by a large number of individuals for the cellular protection from oxidative stress and aging. Here, vitamin E (tocopherol; α/γ and tocotrienol; α/γ; 0, 1, 10, or 100 μM) was tested in human carcinoma cell line, HepG2 for their influences on SULTs expression/(western blotting). The effects of oxidant (glutathione-oxidized/GSSG) or reductant (glutathione-reduced/GSH, Dithiothreitol/DTT) on SULT activities were studied in rat-liver/human intestinal tissues. Results suggest, tocopherol is more inductive to monoamine-SULT (MPST) and Dehydroepiandrosterone-SULT (DHEAST) compared to that of tocotrienol (inconsistent change in PPST, phenol sulfotransferase/MPST/EST, estrogen sulfotransferase). The nuclear-factor constitutive androstane receptor (CAR) was found to be induced moderately. This study overall describes that vitamin E moderately influences SULTs expression. The induction ability of tocopherol should be judged taking into account its long-term consummation. Oxidative stress activates rat and human SULTs activities and expressions. Further studies are necessary in this regard.

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Acknowledgements

Members of Oriental Institute of Science and Technology, Midnapore; Central Instrumentation facility, Dept. Physiological Sciences, Oklahoma State University, Stillwater.

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Authors and Affiliations

  1. Department of Biological Sciences, Midnapore City College, Midnapore, West Bengal, India

    Sangita MaitiDutta

  2. Venture I OSU Laboratory, Oklahoma Technology & Research Park, 1110S. Innovation Way, Stillwater, OK, 74074, USA

    Guangping Chen

  3. Cell and Molecular Therapeutics Laboratory, Department of Biochemistry and Biotechnology, Oriental Institute of Science and Technology, Midnapore, West Bengal, 721102, India

    Smarajit Maiti

  4. Agricure Biotech Research Society, Epidemiology and Human Health Division, Midnapore, West Bengal, 721101, India

    Smarajit Maiti

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  1. Sangita MaitiDutta
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MaitiDutta, S., Chen, G. & Maiti, S. Tocopherol Moderately Induces the Expressions of Some Human Sulfotransferases, which are Activated by Oxidative Stress. Cell Biochem Biophys 78, 439–446 (2020). https://doi.org/10.1007/s12013-020-00938-x

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