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Oxidative Stress Parameters, Trace Elements, and Lipid Profile in Iranian Patients with Gaucher Disease

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Abstract

Gaucher disease (GD) is most frequent disorder of glycolipid storage. The glucosylceramide accumulation might lead to oxidative stress and changes in lipid profile. Regarding the main role of trace elements in hematopoiesis and oxidative stress, this study was aimed to evaluate the zinc and copper levels, three oxidative stress parameters, and lipid profile in GD. Thirty-three patients with GD along with 64 age- and sex-matched healthy controls participated in the study. The levels of zinc and copper were determined using atomic absorption/flame emission spectrophotometer. Malondialdehyde level was measured using HPLC. Total antioxidant capacity (TAC), catalase activity, and lipid profile were assessed using colorimetric methods. Data were analyzed using SPSS software version 16.0. Significant decrease in the serum levels of Zn (p < 0.001) and Cu (p < 0.001) was observed in patients with GD compared to controls. Subjects in control group showed significantly higher levels of TAC than patients with GD (p < 0.001). In contrast, plasma concentration of malondialdehyde was insignificantly higher in patients with GD than controls (p = 0.06). There was a direct correlation between TAC and hemoglobin concentration (p = 0.035; r = 0.369) in patients with GD. Furthermore, the calculated area under receiver operating characteristic curve for HDL cholesterol was equal to 0.938. The results showed that both zinc and copper levels decreased in patients with GD. Patients with GD showed decreased serum content of TAC. It was found that improving the deficiency of zinc and copper by supplementing them could be useful in management of patients with GD.

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Acknowledgments

We gratefully acknowledge the supports by Pasteur Institute of Iran. We also thank the staffs of Tarbiat Modares University, Kermanshah University of Medical Sciences, and Mofid Children’s Hospital of Tehran, Iran.

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Authors and Affiliations

  1. Medical biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Hadi Mozafari & Zohreh Rahimi

  2. Department of Clinical Biochemistry, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Hadi Mozafari, Zohreh Rahimi & Asad Vaisi-Raygani

  3. Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran

    Shohreh Khatami

  4. Regenerative Medicine Research Center (RMRC), Kermanshah University of Medical Sciences, Kermanshah, Iran

    Amir Kiani

  5. Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Asad Vaisi-Raygani

  6. Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

    Azam Afsharnaderi

  7. Department of Pediatric Endocrinology, Faculty of Medicine, Shahid Beheshti University Of Medical Sciences, Shahid Chamran Highway, Tehran, Iran

    Mohammad Reza Alaei

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  1. Hadi Mozafari
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Correspondence to Mohammad Reza Alaei.

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The study protocol was approved by the Ethics Committee of Pasteur Institute of Iran, and all procedures were in accordance with the ethical standards of the institutional research committee.

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Mozafari, H., Khatami, S., Kiani, A. et al. Oxidative Stress Parameters, Trace Elements, and Lipid Profile in Iranian Patients with Gaucher Disease. Biol Trace Elem Res 193, 130–137 (2020). https://doi.org/10.1007/s12011-019-01709-3

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