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Inhibitory Effects of Lanthanum Chloride on Wear Particle-Induced Osteolysis in a Mouse Calvarial Model

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Abstract

Osteolysis is a bone disorder associated with progressive destruction of bone tissues. However, the effects of lanthanum chloride (LaCl3) on osteolysis remain unknown. Therefore, the aim of this study was to determine the effects of LaCl3 on osteolysis in vivo. In a mouse calvarial model, C57BL/6J mice were injected with wear particles with or without LaCl3. Microcomputed tomography, hematoxylin and eosin staining, and tartrate-resistant acid phosphatase staining were performed for the pathological characterization of calvariae, and eight calvariae per group were prepared for the assay of TNF-α, IL-1β, and RANKL secretion using quantitative enzyme-linked immunosorbent assay (ELISA). In mice treated with high-dose LaCl3, particle-induced osteolysis and inflammatory reaction were reduced compared with that in the vehicle-treated control. Moreover, treatment with high-dose LaCl3 suppressed the wear particle-induced decrease in bone mineral content, bone mineral density, and bone volume fraction. Bone destruction and resorption were higher in the LaCl3-treated group than in the saline-treated group but lower than those in the wear particle group. Finally, our results showed that treatment with a high dose of LaCl3 suppressed osteoclastogenesis. Thus, LaCl3 may represent a novel therapeutic agent for the treatment or prevention of wear particle-induced osteolysis and aseptic loosening.

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Funding

This project was supported by the National Natural Science Foundation of China (81160222), the Foundation of Health Department of Jiangxi Province (20121044), and the National Basic Research Program of China (973 Program, Grant No. 2012CB933604). This study was supported by a grant from the Jiangxi Key Laboratory of Gastroenterology & Hepatology.

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The authors declare that they have no conflict of interest associated with the publication of this paper.

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Correspondence to Min Dai.

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Jiang-Yin-Zi Shang and Ping Zhan contributed equally to this work. Chuan Jiang considered the second author.

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Shang, JYZ., Zhan, P., Jiang, C. et al. Inhibitory Effects of Lanthanum Chloride on Wear Particle-Induced Osteolysis in a Mouse Calvarial Model. Biol Trace Elem Res 169, 303–309 (2016). https://doi.org/10.1007/s12011-015-0364-x

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  • DOI: https://doi.org/10.1007/s12011-015-0364-x

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