Skip to main content
SpringerLink
Log in

Effects of 85 dB Noise Exposure on Macro and Trace Element Levels in Plasma and Brain Areas of Rats

  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

In this study, our hypothesis was that workplace noise can alter brain element levels like immobilization and light–dark cycle shift, and we aimed to investigate the effects of workplace noise on element levels of brain areas as well as changes in blood of chronically noise-exposed rats. Twenty-four rats were randomly divided into three groups. The first group was the control. The second group (noise exposed) was subjected to daily 8 h 85 dB workplace noise for 15 days, and the third group (noise exposed plus normal condition) was also subjected to the same noise exposure and then returned to normal condition for 15 days. In noise-exposed group, Na, K, Ca, Mg , Fe, Cu, and Zn levels in plasma significantly increased when compared with controls (p = 0.03 for Na; p = 0.005 for K and Mg; p = 0.002 for Ca and Fe; p = 0.01 for Cu and Zn). In this group, Fe level of temporal lobe significantly increased (p = 0.021) while Mg level significantly increased in frontal (p = 0.021) and temporal (p = 0.001) lobes when compared with controls. In the noise-exposed plus normal condition group, plasma Na, K, Fe, Cu, and Zn levels were greatly similar to controls. But, plasma Ca and Mg levels significantly decreased when compared with controls (p = 0.002 and p = 0.007) and noise-exposed group (p = 0.002 and p = 0.001). Fe level of temporal lobe significantly increased when compared with controls (p = 0.001) and noise exposed group (p = 0.001). These alterations may be attributed to impaired intake of water and micronutrients or their excretions, emerging by acoustic stress.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Bourre JM (2006) Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients. J Nutr Health Aging 10(5):377–385

    PubMed  CAS  Google Scholar 

  2. Ergen K, Ince H, Duzova H et al (2013) Acute effects of moderate and strenuous running on trace element distribution in the brain, liver, and spleen of trained rats. Balk Med J 30:105–110

    Google Scholar 

  3. Leong SF, Lai JC, Lim L et al (1981) Energy-metabolizing enzymes in brain regions of adult and aging rats. J Neurochem 37:1548–1556

    Article  PubMed  CAS  Google Scholar 

  4. Rajan KS, Colburn RW, Davis JM (1976) Distribution of metal ions in the subcellular fractions of several rat brain areas. Life Sci 18:423–431

    Article  PubMed  CAS  Google Scholar 

  5. Hidalgo C, Nunez MT (2007) Calcium, iron and neuronal function. IUBMB Life 59(4–5):280–285

    Article  PubMed  CAS  Google Scholar 

  6. Kaltenbach JA, Czaja JM, Kaplan CR (1992) Changes in the tonotopic map of the dorsal cochlear nucleus following induction of cochlear lesions by exposure to intense sound. Hear Res 59:213–223

    Article  PubMed  CAS  Google Scholar 

  7. Sliwinska-Kowalska M, Davis A (2012) Noise-induced hearing loss. Noise Health 14(61):274–280

    Article  PubMed  Google Scholar 

  8. Jacob S, Johansson C, Fridberger A (2012) Noise-induced alterations in cochlear mechanics, electromotility, and cochlear amplification. Pflugers Arch 465:907–917

    Article  PubMed  Google Scholar 

  9. Grafe TU, Preininger D, Sztatecsny M et al. (2012) Multimodal communication in a noisy environment: a case study of the Bornean rock frog Staurois parvus. PLoS One (5):e37965

  10. Hume KI, Brink M, Basner M (2012) Effects of environmental noise on sleep. Noise Health 14(61):297–302

    Article  PubMed  Google Scholar 

  11. Davies H, Kamp IV (2012) Noise and cardiovascular disease: a review of the literature 2008–2011. Noise Health 14(61):287–291

    Article  PubMed  Google Scholar 

  12. Bluhm G, Eriksson C (2012) Cardiovascular effects of environmental noise: research in Sweden. Noise Health 13(52):212–216

    Article  Google Scholar 

  13. Antoniotti MC, Athanasopoulou A, Barbaglia G et al (2008) Hypertension and exposure to noise near airports: the HYENA study. Environ Health Perspect 116(3):329–333

    Google Scholar 

  14. Sandrock S, Schütte M, Griefahn B (2009) Impairing effects of noise in high and low noise sensitive persons working on different mental tasks. Int Arch Occup Environ Health 82(6):779–785

    Article  PubMed  Google Scholar 

  15. Naqvi F, Haider S, Batool Z et al (2012) Sub-chronic exposure to noise affects locomotor activity and produces anxiogenic and depressive like behavior in rats. Pharmacol Rep 64(1):64–69

    PubMed  Google Scholar 

  16. Reducing the risks from occupational noise. European week for safety and health at work. European Agency for Safety and Health at Work, Belgium, 2005, p.10

  17. Kraus KS, Canlon B (2012) Neuronal connectivity and interactions between the auditory and limbic systems. Effects of noise and tinnitus. Hear Res 288(1–2):34–46

    Article  PubMed  Google Scholar 

  18. Goyal S, Gupta V, Walia L (2010) Effect of noise stress on autonomic function tests. Noise Health 12(48):182–186

    Article  PubMed  Google Scholar 

  19. Mocci F, Canalis P, Tomasi PA et al (2001) The effect of noise on serum and urinary magnesium and catecholamines in humans. Occup Med (Lond) 51(1):56–61

    Article  CAS  Google Scholar 

  20. Bakirdere S, Kizilkan N, Yaman M (2011) Determination of zinc, copper, iron, and manganese in different regions of lamb brain. Biol Trace Elem Res 142:492–499

    Article  PubMed  CAS  Google Scholar 

  21. Sahin S, Toprak S, Unal E (2012) QALY: quality adjusted life year. Med-Sci 1(3):232–243

    Article  Google Scholar 

  22. Reducing the risks from occupational noise. European week for safety and health at work. European Agency for Safety and Health at Work, Belgium, 2005, p.20

  23. Beware: Toy Noise may be too loud for kids. http://hearingaiddocs.wordpress.com/tag/loud-toys access date 22.04.2013

  24. Abumaria N, Yin B, Zhang L et al (2011) Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala. J Neurosci 31(42):14871–14881

    Article  PubMed  CAS  Google Scholar 

  25. Karakoc Y, Buruk MS, Aktan B et al (2011) Effects of chronic light/dark cycle on iron zinc and copper levels in different brain regions of rats. Biol Trace Elem Res 144(13):1003–1007

    Article  PubMed  CAS  Google Scholar 

  26. Jáuregui-Huerta F, Garcia-Estrada J, Ruvalcaba-Delgadillo Y et al (2011) Chronic exposure of juvenile rats to environmental noise impairs hippocampal cell proliferation in adulthood. Noise Health 13(53):286–291

    Article  PubMed  Google Scholar 

  27. Fetoni AR, De Bartolo P, Eramo SL et al (2013) Noise-induced hearing loss (NIHL) as a target of oxidative stress-mediated damage: cochlear and cortical responses after an increase in antioxidant defense. J Neurosci 33(9):4011–4023

    Article  PubMed  Google Scholar 

  28. Naziroglu M (2011) TRPM2 cation channels, oxidative stress and neurological diseases: where are we now? Neurochem Res 36:355–366

    Article  PubMed  CAS  Google Scholar 

  29. Doraiswamy PM, Finefrock AE (2004) Metals in our minds: therapeutic implications for neurodegenerative disorders. Lancet Neurol 3:431–434

    Article  PubMed  CAS  Google Scholar 

  30. Karakoc Y, Turhan S, Yildirim EA et al (2004) Neuropeptide Y alters stress-induced changes in trace element concentrations of brain in chronically immobilized rats. J Trace Elem Exp Med 17(4):283–290

    Article  CAS  Google Scholar 

  31. Naziroglu M (2012) Molecular role of catalase on oxidative stress-induced Ca2+ signaling and TRP cation channel activation in nervous system. J Recept Signal Transduct 32(3):134–141

    Article  CAS  Google Scholar 

  32. Cuajungco MP, Lees GJ (1997) Zinc metabolism in the brain: relevance to human neurodegenerative disorders. Neurobiol Dis 4(3–4):137–169

    Article  PubMed  CAS  Google Scholar 

  33. Gaier ED, Eipper BA, Mains RE (2013) Copper signaling in the mammalian nervous system: synaptic effects. J Neurosci Res 91(1):2–19

    PubMed  CAS  Google Scholar 

  34. Samson J, Sheeladevi R, Ravindran R et al (2007) Stress response in rat brain after different durations of noise exposure. Neurosci Res 57(1):143–147

    Article  PubMed  Google Scholar 

  35. Di GQ, Zhou B, Li ZG et al (2011) Aircraft noise exposure affects rat behavior, plasma norepinephrine levels, and cell morphology of the temporal lobe. Zhejiang Univ Sci B 12(12):969–975

    Article  CAS  Google Scholar 

  36. Akan Z, Yilmaz A, Ozdemir O et al (2012) Noise pollution, psychiatric symptoms and quality of life: noise problem in the east region of Turkey. JIUMF 19(2):75–81

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biophysics, Faculty of Medicine, Inonu University, 44280, Malatya, Turkey

    Yunus Karakoc

  2. Faculty of Medicine, Inonu University, Malatya, Turkey

    Mehmet Hamdi Orum & Mehmet Fatih Dursun

  3. Faculty of Medicine, Selcuk University, Konya, Turkey

    Muhammed Kilic

  4. Department of Chemistry, Faculty of Science and Art, Inonu University, Malatya, Turkey

    Selim Erdogan

Authors
  1. Yunus Karakoc
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mehmet Hamdi Orum
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Muhammed Kilic
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mehmet Fatih Dursun
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Selim Erdogan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yunus Karakoc.

Additional information

This study was supported by Inonu University Scientific Research Foundation and partly presented at the 24th National Biophysics Congress (25–28 September 2012) held in Istanbul, Turkey.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Karakoc, Y., Orum, M.H., Kilic, M. et al. Effects of 85 dB Noise Exposure on Macro and Trace Element Levels in Plasma and Brain Areas of Rats. Biol Trace Elem Res 154, 134–139 (2013). https://doi.org/10.1007/s12011-013-9717-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12011-013-9717-5

Keywords

Search

Navigation