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In the grip of the python: Conflicts at the university-industry interface

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Abstract

When the University of Toronto withdrew a contract it held with me in December 2000, it initiated a sequence of events that led to a public letter to the University from senior figures in the world psychopharmacology community protesting against the infringement of academic freedom involved and a first ever legal action, undertaked by this author, seeking redress for a violation of academic freedom. The issues of academic freedom surrounding this case have been intertwined with a debate about the possibility that the selective serotonin reuptake inhibitor (SSRI) group of antidepressants have the potential to trigger suicidality in a subgroup of patients. Whether the SSRIs do trigger suicidality or not, exploration of this issue has given rise to a number of worrying sets of observations. First, in my view, there is evidence that pharmaceutical companies have miscoded raw data on suicidal acts and suicidal ideation. Second, this author also maintains that there is a growing body of examples of ghostwriting of articles in the therapeutics domain. Many of the tensions evident in this case, therefore, can be linked to company abilities to keep clinical trial data out of the public domain — this is the point at which the pharmaceutical python gets a grip on academia.

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References

  1. Thompson, J., Baird, P., Downie, J. (2001). The Olivieri Report, James Lorimer & Co., Toronto.

    Google Scholar 

  2. Angell, M. (2000). Is academic medicine for sale? New England Journal of Medicine 342: 1516–1518.

    Article  Google Scholar 

  3. Lewis, S., Baird, P., Evans, R.G., Ghalli, W., Wright, C.J., Gibson, E., Bayliss, F. (2001) Dancing with the Porcupine. Rules for governing the university-industry relationship, Canadian Medical Assoc. Journal 165: 783–785.

    Google Scholar 

  4. Teicher, M.H., Glod, C., Cole, J.O. (1990) Emergence of intense suicidal preoccupation during fluoxetine treatment, Am J Psychiatry 147: 207–210.

    Google Scholar 

  5. Creaney, W., Murray, I. and Healy, D. (1991) Antidepressant induced suicidal ideation, Human Psychopharmacology 6: 329–332

    Article  Google Scholar 

  6. Healy, D. (1994) The fluoxetine and suicide controversy, CNS Drugs 1: 223–231

    Google Scholar 

  7. Cornwell, J. (1996) The Power to Harm, Viking Penguin, New York.

    Google Scholar 

  8. Cole, J. O. (1999) Affidavit in Miller vs Pfizer.

  9. Davis, J. (2001) Expert testimony in Miller vs Pfizer, Kansas November 19th.

  10. Oswald, I. (2000) The Halcion Affair. The Psychopharmacologists Volume 3, Arnold, London.

    Google Scholar 

  11. Tobin versus SmithKline Beecham. Case No. 00-CV-0025-BEA.

  12. Healy, D. (1997) The Antidepressant Era, Harvard University Press, Cambridge MA, USA.

    Google Scholar 

  13. Tranter, R., Healy, H., Cattell, D. and Healy, D. (2002) Functional effects of agents differentially selective to noradrenergic or serotonergic systems, Psychological Medicine 32: 517–524.

    Article  Google Scholar 

  14. Healy, D. (2000) Antidepressant induced suicidality, Primary Care Psychiatry 6: 23–28.

    Article  Google Scholar 

  15. Healy, D. (2002) The Creation of Psychopharmacology, Harvard University Press, Cambridge MA. USA.

    Google Scholar 

  16. Thase, M.E., Entsuah, A.R. and Rudolph, R.L. (2001) Remission rates during treatment with venlafaxine and selective serotonin reuptake inhibitors, British Journal of Psychiatry 178, 234–141

    Article  Google Scholar 

  17. Wright, I.C. (2002) Conflict of interest and the British Journal of Psychiatry, British Journal of Psychiatry 180, 82–83

    Article  Google Scholar 

  18. Editorial (2002) Just how tainted has medicine become? Lancet 359: 1167–1168.

  19. Healy, D., Savage, M., Michael, P., Harris, M., Hirst, D. Carter, M., Cattell, D., McMonagle, T., Sohler, N. and Susser, E. (2001) Psychiatric bed utilisation: 1896 and 1996 compared, Psychological Medicine 31, 779–790

    Article  Google Scholar 

  20. Healy, D. (2000) Good Science or Good Business? Hastings Center Report 30: 19–22.

    Article  Google Scholar 

  21. Elliott, C. (2000) Pursued by Happiness and Beaten Senseless, Hastings Center Report 30: 7–12.

    Google Scholar 

  22. Kramer, P. (2000) The valorisation of sadness, Hastings Center Report 30: 13–18.

    Article  Google Scholar 

  23. DeGrazia, D. (2000) Prozac, enhancement and self-creation, Hastings Center Report 30: 34–40.

    Google Scholar 

  24. Edwards, J.C. (2000) Passion, activity and “The Care of the Self”, Hastings Center Report 30: 31–33.

    Google Scholar 

  25. Healy, D. (1999) Guest Editorial: A Failure to Warn, Int J Risk & Safety in Medicine 12: 151–156.

    Google Scholar 

  26. Healy, D. (1999) The Three Faces of the Antidepressants. Critical Comments on the Clinical-Economic Framework of Diagnosis, Journal of Nervous & Mental Disease 187: 174–180

    Article  Google Scholar 

  27. Healy, D., Langmaak, C. and Savage, M. (1999) Suicide in the Course of the Treatment of Depression, Journal of Psychopharmacology 13: 94–99.

    Article  Google Scholar 

  28. Tranter, R, C. O’Donovan, Chandarana, P, and S. Kennedy (2002) Prevalence and outcome of partial remission in depression, Journal of Psychiatry and Clinical Neuroscience 27: 241–247.

    Google Scholar 

  29. Healy, D. (2001c.) Trial testimony in Tobin vs SmithKline, Cheyenne, Wyoming, May 22nd 2001.

  30. Khan, A, Warner, H.A. and Brown, W.A. (2000) Symptom reduction and suicide risk in patients treated with placebo in antidepressant clinical trials, Archives of General Psychiatry 57: 311–317.

    Article  Google Scholar 

  31. Brecher, M. (1991) FDA Review & Evaluation of Clinical Data Original NDA 20-021, Paroxetine Safety Review June 19th 1991.

  32. Lee, H. (1990) Statistical reviews on Sertraline for FDA, August 14th 1990 and January 31st 1991.

  33. Healy, D. (2003). Lines of Evidence on the Risks of Suicide with Selective Serotonin Reuptake Inhibitors. Psychotherapy and Psychosomatics. (Scheduled for publication March 2003.

  34. Lopez-Ibor, J.J. (1993) Reduced suicidality on paroxetine, European Psychiatry 1 (Suppl 8): 17s-19s.

    Google Scholar 

  35. Montgomery, S.A., Dunner, D.L., Dunbar, G. (1995) Reduction of suicidal thoughts with paroxetine in comparison to reference antidepressants and placebo, European Neuropsychopharmacology 5: 5–13.

    Article  Google Scholar 

  36. Davidoff, F., DeAngelis, C.D., Drazen, J.M., et al. (2001) Sponsorship, authorship, and accountability, New England Journal of Medicine 345: 825–827.

    Article  Google Scholar 

  37. Healy, D. (in press). Is academic psychiatry for sale? British Journal of Psychiatry.

  38. Schafer, A. (October 2001) Medicine, morals and money. Dancing with porcupines or sleeping beside elephants. Doctors for research Integrity Meeting, Hart House, Toronto.

  39. Lewis, S., Baird, P., Evans, R.G., Ghalli, W., Wright, C.J., Gibson, E., Bayliss, F. (2001) Dancing with the Porcupine. Rules for governing the university-industry relationship. Canadian Medical Assoc. Journal 165: 783–785.

    Google Scholar 

  40. Healy, D. (2001) When Interests Conflict. Pharmaceutical Executive, August p. 98.

  41. Stecklow S, Johannes L. (1997) “Questions arise on new drug testing. Drug makers relied on clinical researchers who now await trial,” Wall Street Journal, August 15th

  42. Eichenwald K, Kolata G. (1999) “Drug trials hide conflict for doctors,” New York Times, May 16th pages, 1, 28, 29; and “A doctor’s drug studies turn into fraud,” New York Times, May 17th pages 1, 16, 17.

  43. Boseley S. (1999) “Trial and error puts patients at risk,” Guardian (London) July 27th, p 8.

  44. Healy D. (2003/in press). Let them Eat Prozac, Lorimer, Toronto.

    Google Scholar 

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Authors and Affiliations

  1. North Wales Dept of Psychological Medicine, University of Wales College of Medicine, Hergest Unit, LL57 2PW, Bangor, United Kingdom

    David Healy

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  1. David Healy
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Correspondence to David Healy.

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Healy, D. In the grip of the python: Conflicts at the university-industry interface. SCI ENG ETHICS 9, 59–71 (2003). https://doi.org/10.1007/s11948-003-0020-2

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