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The Role of Oncolytic Viruses in the Treatment of Melanoma

  • Melanoma (RJ Sullivan, Section Editor)
  • Published:
Current Oncology Reports Aims and scope Submit manuscript

A Correction to this article was published on 13 November 2018

This article has been updated

Abstract

Purpose of Review

Oncolytic virotherapy is a new approach to the treatment of cancer and its success in the treatment of melanoma represents a breakthrough in cancer therapeutics. This paper provides a review of the current literature on the use of oncolytic viruses (OVs) in the treatment of melanoma.

Recent Findings

Talimogene laherparepvec (T-VEC) is the first OV approved for the treatment of melanoma and presents new challenges as it enters the clinical setting. Several other OVs are at various stages of clinical and pre-clinical development for the treatment of melanoma. Reports from phase Ib-III clinical trials combining T-VEC with checkpoint blockade are encouraging and demonstrate potential added benefit of combination immunotherapy.

Summary

OVs have recently emerged as a standard treatment option for patients with advanced melanoma. Several OVs and therapeutic combinations are in development. Immunooncolytic virotherapy combined with immune checkpoint inhibitors is promising for the treatment of advanced melanoma.

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Change history

  • 13 November 2018

    A correction was made to a sentence in the original article to provide additional clarification in the “Other Oncolytic Viruses” section.

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Authors and Affiliations

  1. Columbia University College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, 10032, USA

    Claire-Audrey Y. Bayan, Adriana T. Lopez, Margaret Bogardus & Cynthia Chen

  2. Department of Medicine, Division of Hematology/Oncology, Columbia University Medical Center, 161 Fort Washington Avenue, New York, NY, 10032, USA

    Robyn D. Gartrell, Kimberly M. Komatsubara, Nisha Rao, Thomas Enzler, Emanuelle M. Rizk, Douglas K. Marks & Yvonne M. Saenger

  3. Columbia College, Columbia University, New York, NY, 10027, USA

    Thomas D. Hart

  4. Department of Pathology, Columbia University Medical Center, New York, NY, 10032, USA

    Jaya Sarin Pradhan

  5. Department of Dermatology, Columbia University Medical Center, New York, NY, 10032, USA

    Larisa J. Geskin

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  3. Robyn D. Gartrell
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  14. Yvonne M. Saenger
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Corresponding author

Correspondence to Yvonne M. Saenger.

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Conflict of Interest

Claire-Audrey Y. Bayan declares that she has no conflict of interest.

Adriana T. Lopez declares that she has no conflict of interest.

Robyn D. Gartrell has received compensation from PerkinElmer for service as a consultant, and (with Yvonne M. Saenger, licensed to Columbia University and Amgen) has a patent pending on “Method of Treating Cancer Using Combination BRAF Inhibitor, Talimogene Laherparepvec, and Immune Checkpoint Inhibitor” (U.S. Provisional Application No. 62/410,206).

Kimberly M. Komatsubara declares that she has no conflict of interest.

Margaret Bogardus declares that she has no conflict of interest.

Nisha Rao declares that she has no conflict of interest.

Cynthia Chen declares that she has no conflict of interest.

Thomas D. Hart declares that he has no conflict of interest.

Thomas Enzler declares that he has no conflict of interest.

Emanuelle M. Rizk declares that she has no conflict of interest.

Jaya Sarin Pradhan declares that she has no conflict of interest.

Douglas K. Marks has received compensation from Takeda for service on an advisory board.

Larisa J. Geskin declares that she has no conflict of interest.

Yvonne M. Saenger has received support through research grants from Amgen to study their oncolytic virus, talimogene laherparepvec; however, Amgen did not support the writing of this article. Along with Robyn D. Gartrell (licensed to Columbia University and Amgen), also has a patent pending on “Method of Treating Cancer Using Combination BRAF Inhibitor, Talimogene Laherparepvec, and Immune Checkpoint Inhibitor” (U.S. Provisional Application No. 62/410,206).

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Melanoma

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Bayan, CA.Y., Lopez, A.T., Gartrell, R.D. et al. The Role of Oncolytic Viruses in the Treatment of Melanoma. Curr Oncol Rep 20, 80 (2018). https://doi.org/10.1007/s11912-018-0729-3

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  • DOI: https://doi.org/10.1007/s11912-018-0729-3

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