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Checkpoint Inhibitors Hodgkin Lymphoma and Non-Hodgkin Lymphoma

  • B-cell NHL, T-cell NHL, and Hodgkin Lymphoma (J Amengual, Section Editor)
  • Published:
Current Hematologic Malignancy Reports Aims and scope Submit manuscript

Abstract

Purpose of the Review

The ligation of PD-1 with PD-L1 activates a critical immune checkpoint leading to T cell dysfunction, exhaustion, and tolerance. Anti-PD-1 or anti-PD-L1 monoclonal antibodies can reverse the immune checkpoint, releasing the brake on T cell responses. We provide a comprehensive review of the literature on the activity of checkpoint inhibitors in lymphoma.

Recent Findings

We discuss the latest findings with checkpoint inhibitors in lymphoma and new promising studies incorporating these agents.

Summary

Classical Hodgkin lymphoma is very sensitive to PD1/PL1 blockade due to genetic alterations in 9p21.1 leading to the high expression of PDL1. Although majority of NHLs have a much lower sensitivity to PD1/PDL1 blockade, a few subtypes such as primary CNS lymphoma, primary testicular lymphoma, primary mediastinal lymphoma harbor 9p21.1 alterations making them vulnerable to PD1 blockade. EBV-associated lymphomas have a virally mediated increased expression of PDL1 making them sensitive to PD1 blockade.

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Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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Authors and Affiliations

  1. Department of Hematologic Malignancies and Blood Disorders, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA

    Bei Hu, Ryan Jacobs & Nilanjan Ghosh

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  1. Bei Hu
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  2. Ryan Jacobs
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Correspondence to Nilanjan Ghosh.

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Nilanjan Ghosh reports personal fees from Seattle Genetics, Pharmacyclics, Gilead, Abbvie, Celgene, Juno Therapeutics, outside the submitted work. Ryan Jacobs reports personal fees from Pharmacyclics, Genentech, Astra Zeneca, TG Therapeutics, Gilead, Spectrum and Juno therapeutics. Bei Hu has no conflict of interest.

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This article is part of the Topical Collection on B cell NHL, T cell NHL, and Hodgkin Lymphoma

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Hu, B., Jacobs, R. & Ghosh, N. Checkpoint Inhibitors Hodgkin Lymphoma and Non-Hodgkin Lymphoma. Curr Hematol Malig Rep 13, 543–554 (2018). https://doi.org/10.1007/s11899-018-0484-4

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