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Role of Palliative Care in the Outpatient Management of the Chronic Heart Failure Patient

  • Nonpharmacologic Therapy: Surgery, Ventricular Assist Devices, Biventricular Pacing, and Exercise (A Hasan, Section Editor)
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Abstract

Purpose of Review

Patients with heart failure (HF) have an increased symptom burden and complex psychosocial and decision-making needs that necessitate the integration of palliative care. However, in the current era, palliative care is frequently evoked for these patients only at the end-of-life or in the inpatient setting; rarely is palliative care proactively utilized in outpatients with HF. The purpose of this review is to evaluate the current state of palliative care and heart failure and to provide a roadmap for the integration of palliative care into outpatient HF care.

Recent Findings

Recent studies, including PAL-HF, CASA, and SWAP-HF, have demonstrated that structured palliative care interventions may improve quality of life, depression, anxiety, understanding of prognosis, and well-being in HF.

Summary

HF is associated with high mortality risk, significant symptom burden, and impaired quality of life. Palliative care can meet many of these needs; however, in the current era, palliative care consultations in HF occur late in the disease course and too often in the inpatient setting. Primary palliative care should be provided to all outpatients with heart failure based on their needs, with referral to secondary palliative care provided based on certain triggers and milestones.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Benjamin EJ, Muntner P, Alonso A, et al. Heart disease and stroke statistics—2019 update: a report from the American Heart Association. Circulation. 2019;139:e56–e528.

    PubMed  Google Scholar 

  2. Curtis LH, Greiner MA, Hammill BG, et al. Early and long-term outcomes of heart failure in elderly persons, 2001-2005. JAMA Intern Med. 2008;168:2481–8.

    Google Scholar 

  3. Jong P, Vowinckel E, Liu PP, Gong Y, Tu JV. Prognosis and determinants of survival in patients newly hospitalized for heart failure: a population-based study. JAMA Intern Med. 2002;162:1689–94.

    Google Scholar 

  4. van Diepen S, Tran DT, Ezekowitz JA, et al. Incremental costs of high intensive care utilisation in patients hospitalised with heart failure. Eur Heart J Acute Cardiovasc Care 8(7),660–666. https://doi.org/10.1177/2048872619845282.

    PubMed  Google Scholar 

  5. Bekelman DB, Havranek EP, Becker DM, et al. Symptoms, depression, and quality of life in patients with heart failure. J Card Fail. 2007;13:643–8.

    PubMed  Google Scholar 

  6. McCarthy M, Lay M, Addington-Hall J. Dying from heart disease. J R Coll Physicians Lond. 1996;30:325–8.

    PubMed  PubMed Central  CAS  Google Scholar 

  7. Chung ML, Lennie TA, Mudd-Martin G, Dunbar SB, Pressler SJ, Moser DK. Depressive symptoms in patients with heart failure negatively affect family caregiver outcomes and quality of life. Eur J Cardiovasc Nurs. 2016;15:30–8.

    PubMed  Google Scholar 

  8. Sepúlveda C, Marlin A, Yoshida T, Ullrich A. Palliative Care: The World Health Organization’s global perspective. J Pain Symptom Manag. 2002;24:91–6.

    Google Scholar 

  9. Allen LA, Stevenson LW, Grady KL, et al. Decision making in advanced heart failure: a scientific statement from the American Heart Association. Circulation. 2012;125:1928–52.

    PubMed  PubMed Central  Google Scholar 

  10. Braun Lynne T, Grady Kathleen L, Kutner Jean S, et al. Palliative care and cardiovascular disease and stroke: a policy statement from the American Heart Association/American Stroke Association. Circulation. 2016;134:e198–225.

    PubMed  CAS  Google Scholar 

  11. Jaarsma T, Beattie JM, Ryder M, et al. Palliative care in heart failure: a position statement from the palliative care workshop of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2009;11:433–43.

    PubMed  Google Scholar 

  12. Yancy Clyde W, Jessup M, Bozkurt B, et al. 2017 ACC/AHA/HFSA focused update of the 2013 ACCF/AHA Guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. Circulation. 2017;136:e137–61.

    PubMed  CAS  Google Scholar 

  13. Warraich HJ, Hernandez AF, Allen LA. How medicine has changed the end of life for patients with cardiovascular disease. J Am Coll Cardiol. 2017;70:1276–89.

    PubMed  Google Scholar 

  14. Warraich HJ, Mentz RJ, Hernandez AF. Paving a better path for patients dying of heart disease. Circulation. 2018;137:1216–7.

    PubMed  PubMed Central  Google Scholar 

  15. Bakitas M, MacMartin M, Trzepkowski K, et al. Palliative care consultations for heart failure patients: how many, when, and why? J Card Fail. 2013;19:193–201.

    PubMed  PubMed Central  Google Scholar 

  16. Alsalem AB, Zheng Z, Huang Y, et al. Palliative care consultations for advanced heart failure patients: experience from a safety-net hospital. J Card Fail. 2018;24:S94.

    Google Scholar 

  17. Warraich HJ, Wolf SP, Mentz RJ, Rogers JG, Samsa G, Kamal AH. Characteristics and trends among patients with cardiovascular disease referred to palliative carecharacteristics and trends among patients with cardiovascular disease referred to palliative carecharacteristics and trends among patients with cardiovascular disease referred to palliative care. JAMA Netw Open. 2019;2:e192375–5.

    PubMed  PubMed Central  Google Scholar 

  18. Gomes B, Calanzani N, Gysels M, Hall S, Higginson IJ. Heterogeneity and changes in preferences for dying at home: a systematic review. BMC Palliat Care. 2013;12:7.

    PubMed  PubMed Central  Google Scholar 

  19. Weitzen S, Teno JM, Fennell M, Mor V. Factors associated with site of death: a national study of where people die. Med Care. 2003;41:323–35.

    PubMed  Google Scholar 

  20. Services CfMaM. Proposed decision memo for ventricular assist devices for bridge-to-transplant and destination therapy (CAG-00432R).

  21. Bekelman DB, Hutt E, Masoudi FA, Kutner JS, Rumsfeld JS. Defining the role of palliative care in older adults with heart failure. Int J Cardiol. 2008;125:183–90.

    PubMed  Google Scholar 

  22. Quill TE, Abernethy AP. Generalist plus specialist palliative care — creating a more sustainable model. N Engl J Med. 2013;368:1173–5.

    PubMed  CAS  Google Scholar 

  23. Kavalieratos D, Gelfman LP, Tycon LE, et al. Palliative care in heart failure. rationale, evidence, and future priorities. 2017;70:1919–1930. https://doi.org/10.1016/j.jacc.2017.08.036.

    PubMed  PubMed Central  Google Scholar 

  24. Fendler TJ, Swetz KM, Allen LA. Team-based palliative and end-of-life care for heart failure. Heart Fail Clin. 2015;11:479–98.

    PubMed  PubMed Central  Google Scholar 

  25. Nakagawa S, Garan AR. Hospice use and palliative care for patients with heart failure: never say never in medicine, but it is never too early to start the conversationpalliative care and hospice for patients with heart failure research. JAMA Cardiol. 2018;3:926–8.

    PubMed  Google Scholar 

  26. • Warraich HJ, Xu H, DeVore AD, et al. Trends in hospice discharge and relative outcomes among medicare patients in the get with the guidelines–Heart Failure Registry Trends in Hospice Discharge and Outcomes Among Medicare Patients in the GWTG-HF Registry Trends in Hospice Discharge and Outcomes Among Medicare Patients in the GWTG-HF Registry. JAMA Cardiol. 2018;3:917–26 This registry review of Medicare-linked claims data of HF patients showed infrequent hospice utilization among HF patients. When referred, patients were often referred too late with brief hospice enrollment.

    PubMed  PubMed Central  Google Scholar 

  27. Xu J, Nolan MT, Heinze K, et al. Symptom frequency, severity, and quality of life among persons with three disease trajectories: cancer, ALS, and CHF. Appl Nurs Res. 2015;28:311–5.

    PubMed  PubMed Central  Google Scholar 

  28. Bekelman DB, Rumsfeld JS, Havranek EP, et al. Symptom burden, depression, and spiritual well-being: a comparison of heart failure and advanced cancer patients. J Gen Intern Med. 2009;24:592–8.

    PubMed  PubMed Central  Google Scholar 

  29. Rumsfeld JS, Alexander KP, Goff DC, et al. Cardiovascular health: the importance of measuring patient-reported health status. Circulation. 2013;127:2233–49.

    PubMed  Google Scholar 

  30. Heo S, Doering LV, Widener J, Moser DK. Predictors and effect of physical symptom status on health-related quality of life in patients with heart failure. Am J Crit Care. 2008;17:124–32.

    PubMed  Google Scholar 

  31. Walke LM, Gallo WT, Tinetti ME, Fried TR. The burden of symptoms among community-dwelling older persons with advanced chronic disease. JAMA Intern Med. 2004;164:2321–4.

    Google Scholar 

  32. Rumsfeld JS, Havranek E, Masoudi FA, et al. Depressive symptoms are the strongest predictors of short-term declines in health status in patients with heart failure. J Am Coll Cardiol. 2003;42:1811–7.

    PubMed  Google Scholar 

  33. Rutledge T, Reis VA, Linke SE, Greenberg BH, Mills PJ. Depression in heart failure: a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. J Am Coll Cardiol. 2006;48:1527–37.

    PubMed  Google Scholar 

  34. Warraich HJ, Kitzman DW, Whellan DJ, et al. Physical function, frailty, cognition, depression, and quality of life in hospitalized adults ≥60 years with acute decompensated heart failure with preserved versus reduced ejection fraction. Circ Heart Fail. 2018;11:e005254.

    PubMed  PubMed Central  Google Scholar 

  35. Levenson JW, McCarthy EP, Lynn J, Davis RB, Phillips RS. The last six months of life for patients with congestive heart failure. J Am Geriatr Soc. 2000;48:S101–9.

    PubMed  CAS  Google Scholar 

  36. Feldman D, Pamboukian SV, Teuteberg JJ, et al. The 2013 International Society for Heart and Lung Transplantation Guidelines for mechanical circulatory support: executive summary. J Heart Lung Transplant. 2013;32:157–87.

    PubMed  Google Scholar 

  37. Solomon SD, Dobson J, Pocock S, et al. Influence of nonfatal hospitalization for heart failure on subsequent mortality in patients with chronic heart failure. Circulation. 2007;116:1482–7.

    PubMed  Google Scholar 

  38. Pulignano G, Del Sindaco D, Tavazzi L, et al. Clinical features and outcomes of elderly outpatients with heart failure followed up in hospital cardiology units: data from a large nationwide cardiology database (IN-CHF Registry). Am Heart J. 2002;143:45–55.

    PubMed  Google Scholar 

  39. Levy Wayne C, Mozaffarian D, Linker David T, et al. The Seattle Heart Failure Model. Circulation. 2006;113:1424–33.

    PubMed  CAS  Google Scholar 

  40. Pocock SJ, Ariti CA, McMurray JJV, et al. Predicting survival in heart failure: a risk score based on 39 372 patients from 30 studies. Eur Heart J. 2012;34:1404–13.

    PubMed  Google Scholar 

  41. Allen LA, Matlock DD, Shetterly SM, et al. Use of risk models to predict death in the next year among individual ambulatory patients with heart failurepredicting death among ambulatory patients with heart failurepredicting death among ambulatory patients with heart failure. JAMA Cardiol. 2017;2:435–41.

    PubMed  Google Scholar 

  42. Straw S, Byrom R, Gierula J, et al. Predicting one-year mortality in heart failure using the ‘Surprise Question’: a prospective pilot study. Eur J Heart Fail. 2019;21:227–34.

    PubMed  Google Scholar 

  43. Allen LA, Yager JE, Funk MJ, et al. Discordance between patient-predicted and model-predicted life expectancy among ambulatory patients with heart failure. JAMA. 2008;299:2533–42.

    PubMed  PubMed Central  CAS  Google Scholar 

  44. Dunlay Shannon M, Swetz Keith M, Mueller Paul S, Roger VL. Advance directives in community patients with heart failure. Circulation. 2012;5:283–9.

    PubMed  CAS  Google Scholar 

  45. Butler J, Binney Z, Kalogeropoulos A, et al. Advance directives among hospitalized patients with heart failure. JACC: Heart Fail. 2015;3:112–21.

    Google Scholar 

  46. Earle CC, Park ER, Lai B, Weeks JC, Ayanian JZ, Block S. Identifying potential indicators of the quality of end-of-life cancer care from administrative data. J Clin Oncol. 2003;21:1133–8.

    PubMed  Google Scholar 

  47. Hoyer T. A History of the Medicare hospice benefit. Hosp J. 1998;13:61–9.

    PubMed  CAS  Google Scholar 

  48. Janssen DJA, Spruit MA, Wouters EFM, Schols JMGA. Family caregiving in advanced chronic organ failure. J Am Med Dir Assoc. 2012;13:394–9.

    PubMed  Google Scholar 

  49. Hooley PJD, Butler G, Howlett JG. The relationship of quality of life, depression, and caregiver burden in outpatients with congestive heart failure. Congest Heart Fail. 2005;11:303–10.

    PubMed  Google Scholar 

  50. Bidwell JT, Lyons KS, Lee CS. Caregiver well-being and patient outcomes in heart failure: a meta-analysis. J Cardiovasc Nurs. 2017;32:372–82.

    PubMed  PubMed Central  Google Scholar 

  51. Garlo K, O’Leary JR, Van Ness PH, Fried TR. Burden in caregivers of older adults with advanced illness. J Am Geriatr Soc. 2010;58:2315–22.

    PubMed  PubMed Central  Google Scholar 

  52. Dunbar Sandra B, Khavjou Olga A, Bakas T, et al. Projected costs of informal caregiving for cardiovascular disease: 2015 to 2035: A Policy Statement From the American Heart Association. Circulation. 2018;137:e558–77.

    PubMed  CAS  Google Scholar 

  53. •• Rogers JG, Patel CB, Mentz RJ, et al. Palliative care in heart failure. The PAL-HF Randomized, Controlled Clinical Trial. J Am Coll Cardiol. 2017;70:331–41 The PAL-HF studied and demonstrated that palliative care involvement in patients in addition to usual care led to improvement in HF-related quality of life, depression, and spiritual wellbeing.

    PubMed  PubMed Central  Google Scholar 

  54. •• O’Donnell AE, Schaefer KG, Stevenson LW, et al. Social worker–Aided Palliative Care Intervention in High-risk Patients With Heart Failure (SWAP-HF): a pilot randomized clinical trial. JAMA Cardiol. 2018;3:516–9 This study showed that intervention led by social work resulted in increased documentation of patient preferences and increased concordance between physician and patient assessment of prognosis.

    PubMed  PubMed Central  Google Scholar 

  55. Gandesbery B, Dobbie K, Gorodeski EZ. Outpatient palliative cardiology service embedded within a heart failure clinic: experiences with an emerging model of care. Am J Hosp Palliat Med. 2017;35:635–9.

    Google Scholar 

  56. Temel JS, Greer JA, Muzikansky A, et al. Early palliative care for patients with metastatic non–small-cell lung cancer. N Engl J Med. 2010;363:733–42.

    PubMed  CAS  Google Scholar 

  57. Koser KD, Ball LS, Homa JK, Mehta V. An outpatient heart failure clinic reduces 30-day readmission and mortality rates for discharged patients: process and preliminary outcomes. J Nurs Res. 2018;26:393–8.

    PubMed  Google Scholar 

  58. Ezekowitz JA, Thai V, Hodnefield TS, Sanderson L, Cujec B. The correlation of standard heart failure assessment and palliative care questionnaires in a multidisciplinary heart failure clinic. J Pain Symptom Manag. 2011;42:379–87.

    Google Scholar 

  59. Zambroski CH, Moser DK, Bhat G, Ziegler C. Impact of symptom prevalence and symptom burden on quality of life in patients with heart failure. Eur J Cardiovasc Nurs. 2005;4:198–206.

    PubMed  Google Scholar 

  60. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16:606–13.

    PubMed  PubMed Central  CAS  Google Scholar 

  61. Setoguchi S, Stevenson LW, Schneeweiss S. Repeated hospitalizations predict mortality in the community population with heart failure. Am Heart J. 2007;154:260–6.

    PubMed  Google Scholar 

  62. Dabbouseh NM, Kaushal S, Peltier W, Johnston FM. Palliative care training in cardiology fellowship: a national survey of the fellows. Am J Hosp Palliat Med. 2017;35:284–92.

    Google Scholar 

  63. Back AL, Arnold RM, Baile WF, et al. Faculty development to change the paradigm of communication skills teaching in oncology. J Clin Oncol. 2009;27:1137–41.

    PubMed  PubMed Central  Google Scholar 

  64. •• Bekelman DB, Allen LA, et al. Effect of a collaborative care intervention vs usual care on health status of patients with chronic heart failure: the CASA Randomized Clinical Trial. JAMA Intern Med. 2018;178(4):511–9 This study showed that though focused symptom and psychosocial intervention did not result in difference in health status, secondary outcomes including depression and fatigue improved.

    PubMed  PubMed Central  Google Scholar 

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Correspondence to Haider J. Warraich.

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Dr. Desai reports personal fees from Abbott, grants and personal fees from Alnylam, grants and personal fees from AstraZeneca, personal fees from Boston Scientific, personal fees from Boehringer Ingelheim, grants and personal fees from Biofourmis, personal fees from DalCor Pharma, grants and personal fees from Novartis, personal fees from Relypsa, and personal fees from Regeneron, outside the submitted work.

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Chuzi, S., Pak, E.S., Desai, A.S. et al. Role of Palliative Care in the Outpatient Management of the Chronic Heart Failure Patient. Curr Heart Fail Rep 16, 220–228 (2019). https://doi.org/10.1007/s11897-019-00440-3

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