Abstract
Purpose of Review
Ischemic disorders of the small bowel represent a rare but highly morbid disease process which is often difficult to diagnose and has a complex management course involving multidisciplinary care. Given recent advances in radiologic modalities and surgical/endovascular techniques, this review seeks to provide a disease overview as well as a summary of emerging management strategies.
Recent Findings
In cases of acute mesenteric ischemia without evidence of frank bowel necrosis, an endovascular-first strategy employing thrombolysis, pharmacomechanical thrombectomy, and/or adjunctive angioplasty/stenting has been shown to have positive outcomes. In cases requiring open laparotomy, retrograde open mesenteric stenting may facilitate less dissection and more straightforward revascularization. While endovascular intervention for chronic mesenteric ischemia was historically limited by high rates of restenosis, use of covered stents in these vascular beds has been shown to have excellent patency rates.
Summary
Ischemia of the small bowel can be acute or chronic in nature—endovascular treatment modalities have been shown to have excellent results given appropriate patient selection and should be an important tool in the armamentarium of management options for this complex disease process.
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References
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Desai A, Shah DS, Bhatt CJ, Vaishnav KU, Salvi B. Measurement of the distance and angle between the aorta and superior mesenteric artery on ct scan: values in Indian population in different BMI categories. Indian J Surg. 2015;77(Suppl 2):614–7.
Kreiss C, Bauer AJ. Intestinal ischemia. xPharm: The Comprehensive Pharmacology Reference. S. Enna, Bylund, DB: Elsevier; 2008.
Herbert G, Steele SR. Acute and chronic mesenteric ischemia. Surg Clin N Am. 2007;87:1115–34.
Kumar S, Sarr MG, Kamath PS. Mesenteric venous thrombosis. N Engl J Med. 2001;345(23):1683–8.
Trompter M, Brazda T, Remy CT, Vestring T, Reimer P. Non-occlusive mesenteric ischemia: etiology, diagnosis, and interventional therapy. Eur J Radiol. 2002;12:1179–87.
Rajkovic Z, Papes D, Altarac S, Arslani N. Differential diagnosis and clinical relevance of pneumobilia or portal vein gas on abdominal x-ray. Acta Clin Croat. 2013;51(3):369–73.
Cudnik M, Darbha S, Jones J, Macedo J, Stockton SW, Hiestand BC. The diagnosis of acute mesenteric ischemia: a systematic review and meta-analysis. Acad Emerg Med. 2013;20(11):1088–100.
van den Heijkant T, Aerts BAC, Teijink JA, Buurman WA, Luyer MDP. Challenges in diagnosing mesenteric ischemia. World J Gastroenterol. 2013;19(9):1338–41.
Martinez J, Hogan GJ. Mesenteric ischemia. Emerg Med Clin North Am. 2004;22:909–28.
Siregar H, Chouc CC. Relative contribution of fat, protein, carbohydrate, and ethanol to intestinal hyperemia. Am J Physiol. 1982;242:G27–31.
Poole J, Sammartano RJ, Boley SJ. Hemodynamic basis of the pain of chronic mesenteric ischemia. Am J Surg. 1987;153:171–6.
Moneta G, Lee RW, Yeager RA, Taylor LM Jr, Porter JM. Mesenteric duplex scanning: a blinded prospective study. J Vasc Surg. 1993;17(1):79–84.
Zhao Y, Yin H, Yao C, Deng J, Wang M, Li Z, et al. Management of acute mesenteric ischemia: a critical review and treatment algorithm. Vasc Endovasc Surg. 2016;50(3):183–92.
• Arthurs Z, Titus J, Bannazadeh M, Eagleton MJ, Srivastava S, Sarac TP, et al. A comparison of endovascular revascularization with traditional therapy for the treatment of acute mesenteric ischemia. J Vasc Surg. 2011;53(3):698–704 This study demonstrated a nearly one-third reduction in laparotomy rate with an endovascular-first approach to treating acute.
Bjornsson S, Bjorck M, Block T, Resch T, Acosta S. Thrombolysis for acute occlusion of the superior mesenteric artery. J Vasc Surg. 2011;54(6):1734–42.
• Ierardi A, Tsetis D, Sbaraini S, Angileri SA, Galanakis N, Petrillo M, Patella F, Panella S, Balestra F, Lucchina N, Carrafiello G. The role of endovascular therapy in acute mesenteric ischemia. Ann Gastroenterol. 2017;30(4):526–533 This overview of endovascular interventions for acute mesenteric ischemia found that thrombectomy was the most commonly employed primary treatment modality for arterial AMI while thrombolysis was the most commonly employed primary treatment modality for mesenteric venous thrombosis.
Freitas B, Bausback Y, Schuster J, Ulrich M, Braunlich S, Schmidt A, et al. Thrombectomy devices in the treatment of acute mesenteric ischemia: initial single-center experience. Ann Vasc Surg. 2018;51:124–31.
Heller S, Lubanda J, Vaerjka P, Chochola M, Prochazka P, Rucka D, et al. Percutaneous mechanical thrombectomy using rotarex s device in acute limb ischemia in infrainguinal occlusions. Hindawi BioMed Res Int. 2017;2017:1–8.
Ballehaninna U, Hingorani A, Scher E, Shiferson A, Marks N, Aboian E, et al. Acute superior mesenteric artery embolism: reperfusion with AngioJet hydrodynamic suction thrombectomy and pharmacologic thrombolysis with the EKOS catheter. Vascular. 2012;20(3):166–9.
VanDenise W, Zawacki JK, Phillips D. Treatment of acute mesenteric ischemia by percutaneous transluminal angioplasty. Gastroenterology. 1986;91(2):475–8.
Karkkainen J, Lehtimaki TT, Saari P, Hartikainen J, Rantanen T, Paajanen H, et al. Endovascular therapy as a primary revascularization modality in acute mesenteric ischemia. Cardiovasc Intervent Radiol. 2015;38(5):1119.
• Erben Y, Protack CD, Jean RA, Sumpio BJ, Miller SM, Liu S, et al. Endovascular interventions decrease length of hospitalization and are cost-effective in acute mesenteric ischemia. J Vasc Surg. 2018;68(2):459–69 This analysis showed that (a) there has been an overall increase over time in the number of cases of AMI diagnosed and treated annually (b) open surgery was associated with 3.4-fold increased in-hospital mortality risk compared with endovascular intervention; (c) endovascular intervention had a mean reduction in hospitalization cost of $9196. This provides further support for the adoption of endovascular strategies.
Blauw J, Meerwaldt R, Brusse-Keizer B, Kokman JJ, Gerrits D, Geelkerken RH. Retrograde open mesenteric stenting for acute mesenteric ischemia. J Vasc Surg. 2014;60(3):726–34.
Oderich G, Gloviczki P, Bower TC. Open surgical treatment for chronic mesenteric ischemia in the endovascular era: when it is necessary and what is the preferred technique? Semin Vasc Surg. 2010;23(1):36–46.
Schermerhorn M, Giles KA, Hamdan AD, Wyers MD, Pomposelli FB. Mesenteric revascularization: management and outcomes in the United States 1988–2006. J Vasc Surg. 2009;50(2):341–8.
Bjorck M, Koelemay M, Acosta S, Bastos Goncalves F, Kolbel T, Kolkman JJ, et al. Management of the diseases of mesenteric arteries and veins. Eur J Vasc Endovasc Surg. 2017;53:460–510.
Fioole B, van de Rest HJM, Meijer JRM, van Leersum M, van Koeverden S, Moll FL, et al. Percutaneous transluminal angioplasty and stenting as first-choice treatment in patients with chronic mesenteric ischemia. J Vasc Surg. 2010;51(2):386–91.
Oderich G, Erdoes LS, LeSar C, Mendes BC, Gloviczki P, Cha S, et al. Comparison of covered stents versus bare metal stents for treatment of chronic atherosclerotic mesenteric arterial disease. J Vasc Surg. 2013;58(5):1316–24.
Mendes B, Oderich GS, Tallarita T, Kanamori KS, Kalra M, Demartino RR, et al. Superior mesenteric artery stenting using embolic protection device for treatment of acute or chronic mesenteric ischemia. J Vasc Surg. 2018.
Oderich G, Macedo R, Stone DH, Woo EY, Panneton JM, Resch T, et al. Multicenter study of retrograde open mesenteric artery stenting through laprarotomy for treatment of acute and chronic mesenteric ischemia. J Vasc Surg. 2018;68(2):470–80.
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Prakash, V.S., Marin, M. & Faries, P.L. Acute and Chronic Ischemic Disorders of the Small Bowel. Curr Gastroenterol Rep 21, 27 (2019). https://doi.org/10.1007/s11894-019-0694-5
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DOI: https://doi.org/10.1007/s11894-019-0694-5