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Diabetes-Related Dysfunction of the Small Intestine and the Colon: Focus on Motility

  • Microvascular Complications—Neuropathy (R Pop-Busui, Section Editor)
  • Published:
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Abstract

In contrast to gastric dysfunction, diabetes-related functional impairments of the small and large intestine have been studied less intensively. The gastrointestinal tract accomplishes several functions, such as mixing and propulsion of luminal content, absorption and secretion of ions, water, and nutrients, defense against pathogens, and elimination of waste products. Diverse functions of the gut are regulated by complex interactions among its functional elements, including gut microbiota. The network-forming tissues, the enteric nervous system) and the interstitial cells of Cajal, are definitely impaired in diabetic patients, and their loss of function is closely related to the symptoms in diabetes, but changes of other elements could also play a role in the development of diabetes mellitus-related motility disorders. The development of our understanding over the recent years of the diabetes-induced dysfunctions in the small and large intestine are reviewed in this article.

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Conflict of Interest

Viktor József Horváth, Zsuzsanna Putz, Ferenc Izbéki, Anna Erzsébet Körei, László Gerő, Csaba Lengyel, Péter Kempler, and Tamás Várkonyi declare that they have no conflict of interest.

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Authors and Affiliations

  1. 1st Department of Medicine, Semmelweis University, Korányi Sándor utca 2/a, 1083, Budapest, Hungary

    Viktor József Horváth, Zsuzsanna Putz, Anna Erzsébet Körei, László Gerő & Péter Kempler

  2. Fejér Megyei Szent György Egyetemi Oktató Kórház, Székesfehérvár, Hungary

    Ferenc Izbéki

  3. 1st Department of Medicine, University of Szeged, Szeged, Hungary

    Csaba Lengyel & Tamás Várkonyi

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  1. Viktor József Horváth
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  2. Zsuzsanna Putz
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Correspondence to Viktor József Horváth.

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This article is part of the Topical Collection on Microvascular Complications—Neuropathy

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Horváth, V.J., Putz, Z., Izbéki, F. et al. Diabetes-Related Dysfunction of the Small Intestine and the Colon: Focus on Motility. Curr Diab Rep 15, 94 (2015). https://doi.org/10.1007/s11892-015-0672-8

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