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The effects of macronutrients on blood pressure and lipids: An overview of the DASH and omniheart trials

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Abstract

Macronutrients are those nutrients (protein, fat, and carbohydrate) that provide energy. The purpose of this review is to highlight findings of three large-scale, isocaloric feeding studies: the Dietary Approaches to Stop Hypertension (DASH) trial, the DASH-Sodium trial, and the Optimal Macro-Nutrient Intake to Prevent Heart Disease (OmniHeart) trial. Each of these trials tested the effects of diets with different macronturient profiles on traditional cardiovascular disease (CVD) risk factors (ie, blood pressure and blood lipids) in the setting of stable weight. The DASH and DASH-sodium trials demonstrated that a carbohydrate-rich diet that emphasizes fruits, vegetables, and low-fat dairy products and that is reduced in saturated fat, total fat, and cholesterol substantially lowered blood pressure and low-density lipoprotein cholesterol. OmniHeart demonstrated that partial replacement of carbohydrate with either protein (about half from plant sources) or with unsaturated fat (mostly monounsaturated fat) can further reduce blood pressure, low-density lipoprotein cholesterol, and coronary heart disease risk. Results from these trials highlight the importance of macronutrients as a determinant of CVD risk. Furthermore, these results also document substantial flexibility that should enhance the ability of individuals to consume a heart-healthy diet.

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Authors and Affiliations

  1. National Institute on Aging, National Institutes of Health, 3001 South Hanover Street, 5th Floor, Room NM-530, 21225, Baltimore, MD, USA

    Edgar R. Miller III MD, PhD

Authors
  1. Edgar R. Miller III MD, PhD
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  2. Thomas P. Erlinger MD, MPH
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  3. Lawrence J. Appel MD, MPH
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Correspondence to Edgar R. Miller III MD, PhD.

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Miller, E.R., Erlinger, T.P. & Appel, L.J. The effects of macronutrients on blood pressure and lipids: An overview of the DASH and omniheart trials. Curr Atheroscler Rep 8, 460–465 (2006). https://doi.org/10.1007/s11883-006-0020-1

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  • DOI: https://doi.org/10.1007/s11883-006-0020-1

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