Abstract
Purpose of Review
Allergic rhinitis and allergic asthma are well-described disease entities with broad exposure in clinical and research allergy forums. Associations between allergic inflammation and upper airway diseases of chronic laryngitis, otitis media, obstructive sleep apnea, and oral allergy syndrome are less well understood and described in the literature.
Recent Findings
This review discusses the relationship between atopy and diseases of the upper airway, oral cavity, larynx, and ear. The similar respiratory mucosal lining the upper aerodigestive tract, with sensitized mast cells and inflammatory mediators in the submucosa, results in a variety of extranasal manifestations of allergic diseases in the head and neck which are less well characterized.
Summary
Associations between allergic inflammation and upper airway diseases of chronic laryngitis, otitis media, obstructive sleep apnea, and oral allergy syndrome are less well understood and described in the literature. This review will summarize the relevant pathophysiology and symptomology, association with allergic sensitization, and clinical considerations of these disorders.
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Dr. Platt and Dr. Brook are consultants for GI Reviewers, LLC, reading blinded studies for biologic therapies for nasal polyps. Dr. Mur declares no conflicts of interest relevant to this manuscript.
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Mur, T., Brook, C. & Platt, M. Extranasal Manifestations of Allergy in the Head and Neck. Curr Allergy Asthma Rep 20, 21 (2020). https://doi.org/10.1007/s11882-020-00914-8
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DOI: https://doi.org/10.1007/s11882-020-00914-8