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High level of circulating microRNA-142 is associated with acute myocardial infarction and reduced survival

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Abstract

Background

Recent study reported that microRNA-142 (miR-142) were up-regulated in the atherosclerotic plaques, which may be responsible for pathogenesis of atherosclerosis. However, whether it associates with presence of acute myocardial infarction (AMI), and its prognostic value is still unknown. We, therefore, investigated the association between miR-142 expression and presence of AMI, and its prognostic value in AMI patients.

Methods

We included 300 AMI patients and 100 subjects as the control group. MiR-142 content was detected by quantitative real-time polymerase chain reaction. MiR-142 level was identified in all subjects. The multivariate logistic regression analysis were performed to evaluate the risk factors of AMI. The Kaplan–Meier analysis was performed to determine the major adverse cardiovascular and cerebrovascular events (MACCE)-free survival.

Results

AMI group had significantly higher miR-142 level in comparison to the controls [4.10 (2.03–7.43) vs. 1.92 (0.91–2.91), p < 0.001], moreover, miR-142 content was significantly associated with cardiac troponin I (cTnI) level (r = 0.707, p < 0.001). The MACCE-free survival was significantly lower over 24-month for patients in miR-142 high expression group (72.4% ± 5.6% vs. 76.4% ± 5.1%) (p = 0.022). After adjusting for the traditional risk factors, the odds ratios of miR-142 was 14.74 (95% CI, 2.15–101.24). The multivariate logistic regression analysis revealed that miR-142 level significantly associated with presence of AMI (p < 0.001).

Conclusion

The serum level of miR-142 was increased in AMI patients when compared with health population. Furthermore, use of this marker may allow a certain predictor of the MACCE in AMI patients.

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Author notes

  1. Xian Guo and Yu Chen contributed equally to this work.

Authors and Affiliations

  1. Department of Cardiology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, Yangpu District, China

    Xian Guo, Yang Lu, Pan Li, Hui Yu, Fan-Rong Diao, Wen-Dong Tang, Pan Hou & Xian-Xian Zhao

  2. Department of Internal Medicine, Chinese People’s Liberation Army Air Force, Huizhou, Huizhou station hospital, Huizhou, 516259, Guangdong, China

    Xian Guo

  3. Intensive Care Unit, 903rd Hospital of the Chinese People’s Liberation Army, Hangzhou, 310013, Zhejiang, China

    Yu Chen

  4. Department of Cardiology, 903rd Hospital of the Chinese People’s Liberation Army, 14 Lingyin Road, Hangzhou, 310013, Zhejiang, China

    Cheng-Yong Shi

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  1. Xian Guo
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Correspondence to Xian-Xian Zhao or Cheng-Yong Shi.

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This study comply with the Ethical Standards and informed consent was obtained from all subjects. The study design and methods complied with the Declaration of Helsinki and was approved by the Ethics Committee and Institutional Review Board of Changhai Hospital. The authors declare that they have no competing interests and no funding.

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Guo, X., Chen, Y., Lu, Y. et al. High level of circulating microRNA-142 is associated with acute myocardial infarction and reduced survival. Ir J Med Sci 189, 933–937 (2020). https://doi.org/10.1007/s11845-020-02196-5

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