Abstract
Background
Numerous studies have demonstrated that elevated serum uric acid concentration (SUA) is correlated with lipid profile in hypertensive or obese patients. However, the relationship between serum uric acid levels and lipid profile in non-obese late adolescent population was not examined before.
Aims
In this study we decided to assess the potential relationship between SUA and lipid profile, according to gender in adolescents with HU.
Methods
The study group comprises 607 Polish adolescents (474 males, 133 females) with HU. Retrospective analysis included demographic, clinical, and laboratory data. Lipid profile was assessed including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), total cholesterol to HDL-C ratio (TC/HDL-C).
Results
In the examined group 187/607 (31 %) of teenagers were diagnosed with metabolic syndrome (MetS). Median BMI-Z-score was 1.11 Q1–Q3: (−0.02–2.03) and both females and males in the upper tertile of SUA had statistically significant higher BMI-Z-score. The males in the upper tertile of serum uric acid levels also had higher values of TG and lower of HDL-C. In females, we have not found significant differences in lipid profile. Multiple regression analyses indicated that male gender, BMI-Z-score, and presence of hypertension correlated significantly with serum uric acid concentration.
Conclusions
In summary, the results of our study confirm higher prevalence of hyperuricemia in males when compared to females and a stronger association of HU with BMI-Z-score and lipid profile in male adolescents. Nevertheless, multiple regression does not confirm the independent association of SUA with lipid profile.
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Stelmach, M.J., Wasilewska, N., Wicklund-Liland, L.I. et al. Blood lipid profile and BMI-Z-score in adolescents with hyperuricemia. Ir J Med Sci 184, 463–468 (2015). https://doi.org/10.1007/s11845-014-1146-8
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DOI: https://doi.org/10.1007/s11845-014-1146-8