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Review of Patient-Specific Vascular Modeling: Template-Based Isogeometric Framework and the Case for CAD

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Abstract

We review the literature on patient-specific vascular modeling, with particular attention paid to three-dimensional arterial networks. Patient-specific vascular modeling typically involves three main steps: image processing, analysis suitable model generation, and computational analysis. Analysis suitable model generation techniques that are currently utilized suffer from several difficulties and complications, which often necessitate manual intervention and crude approximations. Because the modeling pipeline spans multiple disciplines, the benefits of integrating a computer-aided design (CAD) component for the geometric modeling tasks has been largely overlooked. Upon completion of our review, we adopt this philosophy and present a CAD-integrated template-based modeling framework that streamlines the construction of solid non-uniform rational B-spline vascular models for performing isogeometric finite element analysis. Examples of arterial models for mouse and human circles of Willis and a porcine coronary tree are presented.

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Acknowledgements

Support from the William Stamps Farish Fund, Portuguese CoLab grant no UTA06-894, and William & Ella Owens Medical Research Foundation grant no UTA17-000357 are gratefully acknowledged. The authors would also like to thank Zbigniew Starosolski and Ananth Annapragada at the Texas Children’s Hospital, Raja Muthupillai at St. Luke’s Hospital, and Andrea Gobin and Doris Taylor at Texas Heart Institute for providing the imaging data, and for their help with image processing.

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  1. Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX, 78712, USA

    Benjamin Urick, Travis M. Sanders, Shaolie S. Hossain & Thomas J. R. Hughes

  2. Department of Molecular Cardiology, Texas Heart Institute, Houston, TX, 77030, USA

    Shaolie S. Hossain

  3. Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA

    Yongjie J. Zhang

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Correspondence to Shaolie S. Hossain.

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Urick, B., Sanders, T.M., Hossain, S.S. et al. Review of Patient-Specific Vascular Modeling: Template-Based Isogeometric Framework and the Case for CAD. Arch Computat Methods Eng 26, 381–404 (2019). https://doi.org/10.1007/s11831-017-9246-z

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