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Evaluation of folic acid-conjugated chitosan grafted Fe3O4/graphene oxide as a pH- and magnetic field-responsive system for adsorption and controlled release of gemcitabine

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Abstract

A pH-responsive system was prepared by using a magnetic nanocomposite, folic acid-conjugated chitosan (FA-CS) grafted Fe3O4/GO, and then used for loading and controlled release of an anti-cancer drug, gemcitabine (GEM). The successful synthesis of FA-CS/Fe3O4/GO was confirmed by various characterization techniques such as FE-SEM/EDX, TEM, FT-IR, XRD, TGA, VSM, and BET. The nanocomposite had a mesoporous structure with the specific surface area of 68.96 m2 g−1, the pore volume of 0.25 cm3 g−1, and the mean pore size of 14.78 nm. The optimum conditions for drug loading through adsorption were found to be pH=4, adsorbent dosage of 0.5 g L−1, temperature of 298 K, and contact time of 45 min. Experimental data indicated that GEM adsorption onto FA-CS/Fe3O4/GO has a satisfactory correlation with the pseudo-second-order kinetic and Freundlich isotherm equations. The maximum adsorption capacity of GEM was 221.17 mg g−1 for FA-CS/Fe3O4/GO, which was quite higher than the non-functionalized Fe3O4/GO with the value of 33.99 mg g−1. Furthermore, the in-vitro drug release profile of GEM from drug-loaded FA-CS/Fe3O4/GO was studied within 48 hours at 37 °C, and the results indicated a higher drug cumulative release amount in simulated cancer fluid (pH 5.6) compared to simulated human blood fluid (pH 7.4). Also, the Peppas-Sahlin kinetic model best fitted the release kinetics data. The result of drug release implied that FA-CS/Fe3O4/GO magnetic biocomposite could be a potential carrier for the sustained and controlled release of GEM.

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References

  1. X. Fang, J. Cao and A. Shen, J. Drug Deliv. Sci. Technol., 57, 101662 (2020).

    Article  CAS  Google Scholar 

  2. F. U. Din, W. Aman, I. Ullah, O. S. Qureshi, O. Mustapha, S. Shafique and A. Zeb, Int. J. Nanomedicine, 12, 7291 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  3. S. Hossen, M. K. Hossain, M. K. Basher, M. N. H. Mia, M. T. Rahman and M. J. Uddin, J. Adv. Res., 15, 1 (2019).

    Article  CAS  PubMed  Google Scholar 

  4. B. D. Kevadiya, G. V. Joshi, H. A. Patel, P. G. Ingole, H. M. Mody and H. C. Bajaj, J. Biomater. Appl., 25, 161 (2010).

    Article  CAS  PubMed  Google Scholar 

  5. A. Z. Juthi, M. Aquib, M. A. Farooq, S. Ghayas, F. Khalid, G. F. Boafo, D. P. Wande, D. H. Khan, T. Z. Bithi, R. Bavi and B. Wang, Environ. Chem. Lett., 18, 1509 (2020).

    Article  CAS  Google Scholar 

  6. P. Makvandi, M. Ghomi, M. Ashrafizadeh, A. Tafazoli, T. Agarwal, M. Delfi, J. Akhtari, E. N. Zare, V.V.T. Padil, A. Zarrabi, N. Pourreza, W. Miltyk and T K. Maiti, Carbohydr. Polym., 250, 116952 (2020).

    Article  CAS  PubMed  Google Scholar 

  7. A. A. Ghawanmeh, G. A. M. Ali, H. Algarni, S. M. Sarkar and K. F. Chong, Nano Res., 12, 973 (2019).

    Article  CAS  Google Scholar 

  8. S. Gooneh-Farahani, M. R. Naimi-Jamal and S. M. Naghib, Expert. Opin. Drug Deliv., 16, 79 (2018).

    Article  PubMed  CAS  Google Scholar 

  9. S. W. Jun, P. Manivasagan, J. Kwon, V. T. Nguyen, S. Mondal, C. D. Ly, J. Lee, Y. H. Kang, C. S. Kim, and J. Oh, Int. J. Biol. Macromol., 155, 961 (2020).

    Article  CAS  PubMed  Google Scholar 

  10. C. Chen, W. Yao, W. Sun, T. Guo, H. Lv, X. Wang, H. Ying, Y. Wang and P. Wang, Int. J. Biol. Macromol., 122, 1090 (2019).

    Article  CAS  PubMed  Google Scholar 

  11. S. Karki, M. B. Gohain, D. Yadav and P. G. Ingole, Int. J. Biol. Macromol., 193, 2121 (2021).

    Article  CAS  PubMed  Google Scholar 

  12. P. G. Ingole and N. P. Ingole, Korean J. Chem. Eng., 31, 2109 (2014).

    Article  CAS  Google Scholar 

  13. F. Xu, T. Zhao, T. Yang, L. Dong, X. Guan and X. Cui, Colloids Surf. A Physicochem. Eng. Asp., 490, 22 (2016).

    Article  CAS  Google Scholar 

  14. P. Ebrahimnejad, A. Sodagar Taleghani, K. Asare-Addo and A. Nokhodchi, Drug Discov. Today, 27, 471 (2022).

    Article  CAS  PubMed  Google Scholar 

  15. P. Dramou, M. Fizir, A. Taleb, A. Itatahine, N. S. Dahiru, Y. A. Mehdi, L. Wei, J. Zhang and H. He, Carbohydr. Polym., 197, 117 (2018).

    Article  CAS  PubMed  Google Scholar 

  16. P. Pakdaman Goli, M. Bikhof Torbati, K. Parivar, A. Akbarzadeh Khiavi and M. Yousefi, J. Drug Deliv. Sci. Technol., 65, 102756 (2021).

    Article  CAS  Google Scholar 

  17. A. Deb and R. Vimala, J. Drug Deliv. Sci. Technol., 43, 333 (2018).

    Article  CAS  Google Scholar 

  18. M. De Sousa, L. A. Visani De Luna, L. C. Fonseca, S. Giorgio and O. L. Alves, ACS Appl. Nano Mater., 1, 922 (2018).

    Article  CAS  Google Scholar 

  19. Z. Wang, C. Zhou, J. Xia, B. Via, Y. Xia, F. Zhang, Y. Li and L. Xia, Colloids Surf. B Biointerfaces, 106, 60 (2013).

    Article  CAS  PubMed  Google Scholar 

  20. H. Hu, C. Tang and C. Yin, Mater. Lett., 125, 82 (2014).

    Article  CAS  Google Scholar 

  21. K. Vinothini, N. K. Rajendran, A. Ramu, N. Elumalai and M. Rajan, Biomed. Pharmacother., 110, 906 (2019).

    Article  CAS  PubMed  Google Scholar 

  22. B. K. Purushothaman, M. Harsha S. P. U. Maheswari and K. M. M. Sheriffa Begum, J. Drug Deliv. Sci. Technol., 52, 509 (2019).

    Article  CAS  Google Scholar 

  23. K. Krishnamoorthy, G. S. Kim and S. J. Kim, Ultrason. Sonochem., 20, 644 (2013).

    Article  CAS  PubMed  Google Scholar 

  24. S. E. Rokni, R. Haji Seyed Mohammad Shirazi, M. Miralinaghi and E. Moniri, Res. Chem. Intermed., 46, 2247 (2020).

    Article  CAS  Google Scholar 

  25. M. Shafaati, M. Miralinaghi, R. H. S. M. Shirazi and E. Moniri, Res. Chem. Intermed., 46, 5231 (2020).

    Article  CAS  Google Scholar 

  26. I. Langmuir, J. Am. Chem. Soc., 40, 1361 (1918).

    Article  CAS  Google Scholar 

  27. H. M. F. Freundlich, Z. Phys. Chem., 57, 385 (1906).

    CAS  Google Scholar 

  28. M. I. Temkin and V. Pyzhev, Acta Phys. Chim. USSR, 12, 327 (1940).

    CAS  Google Scholar 

  29. M. M. Dubinin and L. V. Radushkevich, Proc. Acad. Sci. USSR Phys. Chem. Sect., 55, 331 (1947).

    Google Scholar 

  30. S. Lagergren, Sven. Veten. Handl., 24, 1 (1898).

    Google Scholar 

  31. Y. S. Ho and G. McKay, Process Biochem., 34, 451 (1999).

    Article  CAS  Google Scholar 

  32. I. S. McLintock, Nature, 216, 1204 (1967).

    Article  CAS  Google Scholar 

  33. Y. S. Ho and G. McKay, Adsorp. Sci. Technol., 20, 797 (2002).

    Article  CAS  Google Scholar 

  34. S. Alharthi and M. O. A. El-Magied, Korean J. Chem. Eng., 38, 2365 (2021).

    Article  CAS  Google Scholar 

  35. A. Hashem, C. O. Aniagor, S. M. Badawy and G. M. Taha, Korean J. Chem. Eng., 38, 2256 (2021).

    Article  CAS  Google Scholar 

  36. S. P. Hooshyar, R. Z. Mehrabian, H. A. Panahi, M. H. Jouybari and H. Jalilian, Colloids Surf. B Biointerfaces, 176, 404 (2019).

    Article  CAS  PubMed  Google Scholar 

  37. N. Torabi Fard, F. Tadayon, H. Ahmad Panahi and E. Moniri, J. Mol. Liq., 349, 118149 (2021).

    Article  CAS  Google Scholar 

  38. S. Dash, P. N. Murthy, L. Nath and P. Chowdhury, Acta Pol. Pharm., 67, 217 (2010).

    CAS  PubMed  Google Scholar 

  39. T. Higuchi and N. York, J. Pharm. Sci., 52, 1145 (1963).

    Article  CAS  PubMed  Google Scholar 

  40. R. W. Korsmeyer, R. Gurny, E. Doelker, P. Buri and N. A. Peppas, Int. J. Pharm., 15, 25 (1983).

    Article  CAS  Google Scholar 

  41. N. A. Peppas and J. J. Sahlin, Int. J. Pharm., 57, 169 (1989).

    Article  CAS  Google Scholar 

  42. E. Aliyari, A. A. Fathi, M. Alvand, P. Jamshidi, F. Shemirani, S. Mozaffari and M. R. Neyestani, Res. Chem. Intermed., 47, 1905 (2021).

    Article  CAS  Google Scholar 

  43. A. Homayonfard, M. Miralinaghi, R. H. S. M. Shirazi and E. Moniri, Water Sci. Technol., 78, 2297 (2018).

    Article  CAS  PubMed  Google Scholar 

  44. Y. B. Kontaç, E. Erçarikci and M. Alanyalioğłu, Res. Chem. Intermed., 47, 3853 (2021).

    Article  CAS  Google Scholar 

  45. P. G. Ingole, H. C. Bajaj and K. Singh, Arab. J. Chem., 9, S960 (2016).

    Article  CAS  Google Scholar 

  46. P. Khorshidi, R. H. S. M. Shirazi, M. Miralinaghi, E. Moniri and S. Saadi, Res. Chem. Intermed., 1 (2020).

  47. P. Miralinaghi, P. Kashani, E. Moniri and M. Miralinaghi, Mater. Res. Express, 6, 065305 (2019).

    Article  CAS  Google Scholar 

  48. P. Jamshidi and F. Shemirani, Res. Chem. Intermed., 46, 4403 (2020).

    Article  CAS  Google Scholar 

  49. A. I. Adeogun, O. A. Osideko, M. A. Idowu, V. Shappur, O. A. Akinloye and B. Ramesh Babu, SN Appl. Sci., 2, 795 (2020).

    Article  CAS  Google Scholar 

  50. H. Ansari, M. Miralinaghi and F. Azizinezhad, Cellul. Chem. Technol., 53, 191 (2019).

    Article  CAS  Google Scholar 

  51. L. Hou, C. Yang, X. Rao, L. Hu, Y. Bao, Y. Gao and X. Zhu, Colloids Surf. A Physicochem. Eng. Asp., 625, 126949 (2021).

    Article  CAS  Google Scholar 

  52. S. Hamarat Sanlier, M. Yasa, A. O. Cihnioglu, M. Abdulhayoglu, H. Yilmaz and G. Ak, Artif. Cells, Nanomedicine, Biotechnol., 44, 943 (2016).

    CAS  Google Scholar 

  53. J. Zhang, M. S. Azam, C. Shi, J. Huang, B. Yan, Q. Liu and H. Zeng, RSC Adv., 5, 32272 (2015).

    Article  CAS  Google Scholar 

  54. A. Barazandeh, H. A. Jamali and H. Karyab, Korean J. Chem. Eng., 38, 2436 (2021).

    Article  CAS  Google Scholar 

  55. S. Karimidost, E. Moniri and M. Miralinaghi, Korean J. Chem. Eng., 36, 1115 (2019).

    Article  CAS  Google Scholar 

  56. M. A. A. Marhalim, S. S. Mohtar, A. M. Mohammed, F. Aziz, M. N. M. Sokri, W. N. W. Salleh, N. Yusof, J. Jaafar, A. F. Ismail, M. Aziz and R. Naim, Korean J. Chem. Eng., 38, 1648 (2021).

    Article  CAS  Google Scholar 

  57. L. Sun, S. Hu, H. Sun, H. Guo, H. Zhu, M. Liu and H. Sun, RSC Adv., 5, 11837 (2015).

    Article  CAS  Google Scholar 

  58. W. Janusz, V. Sydorchuk, E. Skwarek, S. Khalameida, J. Skubiszewska-Zięba and R. Leboda, Appl. Nanosci., 1, 1 (2021).

    Google Scholar 

  59. C. Lim, E. B. Cho and D. Kim, Korean J. Chem. Eng., 36, 166 (2019).

    Article  CAS  Google Scholar 

  60. S. F. Kaboli, F. Mehrnejad and A. Nematollahzadeh, J. Drug Deliv. Sci. Technol., 64, 102588 (2021).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Varamin - Pishva Branch, Islamic Azad University, Varamin, Iran

    Arsalan Ashuri, Mahsasadat Miralinaghi & Elham Moniri

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  1. Arsalan Ashuri
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  2. Mahsasadat Miralinaghi
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  3. Elham Moniri
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Correspondence to Mahsasadat Miralinaghi.

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11814_2022_1104_MOESM1_ESM.pdf

Evaluation of folic acid-conjugated chitosan grafted Fe3O4/graphene oxide as a pH- and magnetic field-responsive system for adsorption and controlled release of gemcitabine

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Ashuri, A., Miralinaghi, M. & Moniri, E. Evaluation of folic acid-conjugated chitosan grafted Fe3O4/graphene oxide as a pH- and magnetic field-responsive system for adsorption and controlled release of gemcitabine. Korean J. Chem. Eng. 39, 1880–1890 (2022). https://doi.org/10.1007/s11814-022-1104-5

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