Abstract
Air leak syndrome (ALS) is a rare complication after bone marrow transplantation (BMT) and usually has a fatal outcome because of the high recurrence rate and treatment-refractory nature. A 32-year-old man with a history of BMT for acute lymphoblastic leukemia suffered from metachronous bilateral ALS. Bullectomy and the pleural covering procedure (PLC) were successfully performed for each side of the thorax. After surgery, no relapse of pneumothorax was seen for 2 years on the right side and for 1 year on the left side. A 38-year-old man with a history of BMT for acute myelogenous leukemia (AML) suffered from ALS at the thorax on the left side. Bullectomy and the PLC were successfully performed. After that no recurrence of left pneumothorax for 7 years. We experienced two cases of ALS after BMT successfully treated by the PLC. This technique may be a viable treatment option for future lung transplantation.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Kurihara M, Kataoka H, Ishikawa A, Endo R. Latest treatments for spontaneous pneumothorax. Gen Thorac Cardiovasc Surg. 2010;58(3):113–9.
Bergeron A. Late-Onset Noninfectious Pulmonary Complications After Allogeneic Hematopoietic Stem Cell Transplantation. Clin Chest Med. 2017;38(2):249–62.
Chen-Yoshikawa TF, Okumura M, Miyoshi S, Oto T, Date H, et al. Prognostic factors in lung transplantation after hematopoietic stem cell transplantation. Transplantation. 2018;102(1):154–61.
Sakai R, Kanamori H, Nakaseko C, Yoshiba F, Fujimaki K, et al. Air-leak syndrome following allo-SCT in adult patients: report from the Kanto study group for cell therapy in Japan. Bone Marrow Transpl. 2011;46(3):379–84.
Franquet T, Rodríguez S, Hernández JM, Martino R, Giménez A, et al. Air-leak syndromes in hematopoietic stem cell transplant recipients with chronic GVHD: high-resolution CT findings. J Thorac Imaging. 2007;22:335–40.
Almoosa KF, Ryu JH, Mendez J, Huggins JT, Young LR, et al. Management of pneumothorax in lymphangioleiomyomatosis: effects on recurrence and lung transplantation complications. Chest. 2006;129:1274–81.
Kurihara M, Mizobuchi T, Kataoka H, Sato T, Kumasaka T, et al. A Total Pleural Covering for Lymphangioleiomyomatosis Prevents Pneumothorax Recurrence. PLoS One. 2016;11(9).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors have no conflicts of interest to declare.
Ethical approval
The study protocol was approved by the Ethical Review Board for Clinical Studies at Osaka University (control number 10026-3).
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Kunou, H., Kanzaki, R., Kawamura, T. et al. Two cases of air leak syndrome after bone marrow transplantation successfully treated by the pleural covering technique. Gen Thorac Cardiovasc Surg 67, 987–990 (2019). https://doi.org/10.1007/s11748-018-01057-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11748-018-01057-4