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The relationship between platelet count and bone mineral density: results from two independent population-based studies

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Abstract

Summary

In two population-based study of middle-aged and older people, we investigated if platelet count was associated with bone mineral density and determined whether the association remained over time. Highest platelet counts within the normal range are significantly associated with osteopenia and osteoporosis in middle-aged and elderly people.

Purpose

Recently, platelets were found to play a role in bone remodeling. However, data on the association between platelet count and osteoporosis are lacking. Our study aimed to investigate the association between platelet counts, osteopenia, and osteoporosis in middle-aged and elderly Koreans.

Methods

We analyzed cross-sectional data from 5181 adults (postmenopausal women and men over 50 years of age) in the 2008–2011 Korea National Health and Nutrition Examination Survey (KNHANES) and longitudinal prospective data from 3312 adults over 50 years of age in the Korean Genome and Epidemiology Study (KoGES). Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry in the KNHANES and quantitative ultrasound in the KoGES. The platelet counts were categorized into quintiles within normal ranges (150–450 × 103 μL). The associations between platelet counts, osteopenia, and osteoporosis were estimated using a multinomial logistic model.

Results

BMD of the femur neck, total femur, and lumbar spine all decreased with increasing platelet counts. The cut-off points of the platelet counts to differentiate normal BMD from osteopenia and osteopenia from osteoporosis were 217 × 103/μL and 269 × 103/μL, respectively. The odds ratios (95% confidence intervals) in the highest platelet quartile were 1.39 (1.03–1.88) for osteopenia and 1.60 (1.07–2.37) for osteoporosis after adjusting for confounding factors. The distal radius T-score was significantly decreased in the highest platelet tertile group at a follow-up of 10 years.

Conclusion

Highest platelet counts within the normal range are significantly associated with osteopenia and osteoporosis in middle-aged and elderly people.

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Acknowledgments

Data in this study were from the KoGES 4851-302, National Research Institute of Health, Centers for Disease Control and Prevention, Ministry for Health and Welfare, Republic of Korea.

Funding

This study was financially supported by a 2018 faculty research grant from Yonsei University College of Medicine [6-2018-0090] to Yu-Jin Kwon.

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Author notes

  1. Hye Sun Lee and Yu-Jin Kwon are co-corresponding authors who contributed equally to this work.

Authors and Affiliations

  1. Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Gyeonggi-do, Republic of Korea

    Jiwoon Kim

  2. Department of Orthopaedic Surgery, Yongin Severance Hospital, Yonsei University College of Medicine, Gyeonggi-do, Republic of Korea

    Hyoung Sik Kim

  3. Biostatistics Collaboration Unit, Department of Research Affairs, Yonsei University College of Medicine, Seoul, Republic of Korea

    Hye Sun Lee

  4. Department of Family Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Gyeonggi-do, Republic of Korea

    Yu-Jin Kwon

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Correspondence to Hye Sun Lee or Yu-Jin Kwon.

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Kim, J., Kim, H.S., Lee, H.S. et al. The relationship between platelet count and bone mineral density: results from two independent population-based studies. Arch Osteoporos 15, 43 (2020). https://doi.org/10.1007/s11657-020-0700-4

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