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Radiation with concomitant superselective intra-arterial cisplatin infusion for maxillary sinus squamous cell carcinoma

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Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Purpose

To assess the efficacy and prognostic factors after superselective intra-arterial chemoradiation (RADPLAT) for maxillary sinus squamous cell carcinoma (MS-SCC).

Materials and methods

Prognostic significance of age, gender, T and N factors, gross tumor volume of the primary-site (GTV), total cisplatin dosage, and total cisplatin dosage per GTV (CDDP/GTV) for primary-site recurrence-free survival rate (PRFS) were analyzed. RADPLAT was administered to 27 patients. The median follow-up period was 42.1 months.

Results

The 3-year rates of overall survival and PRFS were 59.2% and 53.9%, respectively. In univariate analysis, age, male, and total cisplatin dosage were significant factors for PRFS. In multivariate analysis, lymph node metastasis was significant factors for PRFS, and gender and total cisplatin dosage weakly influenced PRFS. In acute phase, no patient showed ≥ grade 3 hematologic toxicity, and grade 3 mucositis developed in 5 patients. Late toxicities were recognized in 3 patients (grade 2 phlegmon of the face, grade 3 maxillofacial osteonecrosis, and retinopathy). Twelve patients (44%) experienced recurrences. Of them, 8 patients showed recurrence at the primarysite.

Conclusion

RADPLAT was effective for MS-SCC, with acceptable toxicity. Total cisplatin dosage is suggested to be important for primary tumor control.

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Funding

This research was supported by Grand-in-Aid (B-10, 2017) of Gunma Prefectural Cancer Center in Japan.

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Authors and Affiliations

  1. Department of Radiation Oncology, Gunma Prefectural Cancer Center, 617-1 Takabayashinishi-machi, Ota, 373-8550, Gunma, Japan

    Takeshi Ebara, Ken Ando & Jun Eishima

  2. Department of Head and Neck Surgery, Gunma Prefectural Cancer Center, Ota, Gunma, Japan

    Masami Suzuki

  3. Department of Radiology, Gunma Prefectural Cancer Center, Ota, Gunma, Japan

    Takeshi Kawakami & Hiroyuki Horikoshi

  4. Department of Radiation Oncology, Tsukuba University Hospital, Tsukuba, Ibaraki, Japan

    Yoshio Tamaki

Authors
  1. Takeshi Ebara
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  2. Ken Ando
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  3. Jun Eishima
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  4. Masami Suzuki
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  5. Takeshi Kawakami
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  6. Hiroyuki Horikoshi
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  7. Yoshio Tamaki
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Corresponding author

Correspondence to Takeshi Ebara.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the present study were in accordance with the ethical standards of the institutional committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Ebara, T., Ando, K., Eishima, J. et al. Radiation with concomitant superselective intra-arterial cisplatin infusion for maxillary sinus squamous cell carcinoma. Jpn J Radiol 37, 494–499 (2019). https://doi.org/10.1007/s11604-019-00827-1

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  • DOI: https://doi.org/10.1007/s11604-019-00827-1

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