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Clinical utility of gadoxetate disodium-enhanced hepatic MRI for stereotactic body radiotherapy of hepatocellular carcinoma

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Abstract

Purpose

To investigate the utility of gadoxetate disodium-enhanced hepatic MRI (EOB-MRI) for stereotactic body radiotherapy (SBRT) to treat hepatocellular carcinoma (HCC).

Materials and methods

We divided 30 HCC patients who underwent SBRT into group A (no change in their Child-Pugh score 6 months post-SBRT) and group B (increased score 6 months post-SBRT). EOB-MRI was performed before and 6 months after SBRT. We calculated the liver-spleen contrast (LSC) ratio for each radiation dose area on hepatobiliary phase scans (LSCbefore using images obtained before SBRT and LSCafter using images acquired after SBRT) and the weighted LSC (W-LSC) as: [(mean LSCbefore (0–30 Gy) × liver volume (0–30 Gy) + mean LSCbefore (30 Gy-) × liver volume (30 Gy-))/total liver volume]. Then we compared the W-LSC, percentage of the liver volume exposed to >20 Gy (V20), and mean liver dose in the two groups.

Results

The LSCafter at 48, 40, and 30 Gy to the liver was statistically lower than the unirradiated area of the liver (p < 0.01). Univariate analysis showed that only W-LSC was significantly associated with group B (p = 0.02).

Conclusion

W-LSC was a useful parameter for predicting changes in hepatic function after SBRT.

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Author notes

  1. Takuji Yamagami

    Present address: Department of Radiology, Kochi University, Kohasu, Oko-Cho, Nankoku, Kouchi, Japan

Authors and Affiliations

  1. Diagnostic Radiology, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan

    Yuko Nakamura, Toru Higaki, Yukiko Honda, Daisuke Komoto, Takuji Yamagami, Makoto Iida & Kazuo Awai

  2. Radiation Oncology, Hiroshima University, Hiroshima, Japan

    Tomoki Kimura & Yasushi Nagata

  3. Departments of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan

    Yohji Honda, Hiroshi Aikata & Kazuaki Chayama

  4. Hiroshima Liver Research Project Center, Hiroshima, Japan

    Yohji Honda, Hiroshi Aikata & Kazuaki Chayama

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  1. Yuko Nakamura
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Corresponding author

Correspondence to Yuko Nakamura.

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Conflict of interest

Kazuo Awai received a research grant from Toshiba Medical Systems Co., Ltd. The other authors declare that they have no conflict of interest.

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Nakamura, Y., Kimura, T., Higaki, T. et al. Clinical utility of gadoxetate disodium-enhanced hepatic MRI for stereotactic body radiotherapy of hepatocellular carcinoma. Jpn J Radiol 33, 627–635 (2015). https://doi.org/10.1007/s11604-015-0465-7

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  • DOI: https://doi.org/10.1007/s11604-015-0465-7

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