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Effects of Norepinephrine on Renal Cortical and Medullary Blood Flow in Atherosclerotic Rabbits

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Abstract

Objective

The aim of this study was to explore the effect of norepinephrine (NE) on renal cortical and medullary blood flow in atherosclerotic rabbits without renal artery stenosis.

Methods

Atherosclerosis was induced in 21 New Zealand white rabbits by feeding them a cholesterol-rich diet for 16 weeks. Thirteen healthy New Zealand white rabbits were randomly selected as controls. After atherosclerosis induction, standard ultrasonography was performed to confirm that there was no plaque or accelerated flow at the origin of the renal artery. Contrast-enhanced ultrasound (CEUS) was performed at baseline and during intravenous injection of NE. The degree of contrast enhancement of renal cortex and medulla after the injection of contrast agents was quantified by calculating the enhanced intensity.

Results

The serum nitric oxide (NO) level in atherosclerotic rabbits was higher than that in healthy rabbits (299.6±152 vs. 136.5±49.5, P<0.001). The infusion of NE induced a significant increase in the systolic blood pressure (112±14 mmHg vs. 84±9 mmHg, P=0.016) and a significant decrease in the enhanced intensity in renal cortex (17.78±2.07 dB vs. 21.19±2.03 dB, P<0.001) and renal medulla (14.87±1.82 dB vs. 17.14±1.89 dB, P<0.001) during CEUS. However, the enhanced intensity in the cortex and medulla of healthy rabbits after NE infusion showed no significant difference from that at baseline.

Conclusion

NE may reduce renal cortical and medullary blood flow in atherosclerotic rabbits without renal artery stenosis, partly by reducing the serum NO level.

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Authors and Affiliations

  1. Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Jia-yu Wang, Jie Sun & You-bin Deng

  2. Department of Medical Ultrasound, Maternal and Child Healthcare Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430064, China

    Yu-bo Wang

  3. Department of Medical Ultrasound, The Third People’s Hospital of Hubei Province, Wuhan, 430030, China

    Kun Liu

Authors
  1. Jia-yu Wang
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  2. Jie Sun
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  3. You-bin Deng
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  4. Yu-bo Wang
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  5. Kun Liu
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Corresponding author

Correspondence to Jie Sun.

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The authors declare that there is no conflict of interest with any financial organization or corporation or individual that can inappropriately influence this work.

Additional information

This work was supported by grants from Health and Family Planning Commission Foundation of Hubei Province (No. WJ2017M080) and the National Natural Science Foundation of China (No. 81601507).

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Wang, Jy., Sun, J., Deng, Yb. et al. Effects of Norepinephrine on Renal Cortical and Medullary Blood Flow in Atherosclerotic Rabbits. CURR MED SCI 42, 1172–1177 (2022). https://doi.org/10.1007/s11596-022-2626-0

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  • DOI: https://doi.org/10.1007/s11596-022-2626-0

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