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Implications of Necroptosis for Cardiovascular Diseases

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Summary

Necroptosis is a non-apoptotic programmed cell death pathway, which causes necrosis-like morphologic changes and triggers inflammation in the surrounding tissues. Accumulating evidence has demonstrated that necroptosis is involved in a number of pathological processes that lead to cardiovascular diseases. However, the exact molecular pathways linking them remain unknown. Herein, this review summarizes the necroptosis-related pathways involved in the development of various cardiovascular diseases, including atherosclerosis, cardiac ischemia-reperfusion injury, cardiac hypertrophy, dilated cardiomyopathy and myocardial infarction, and may shed light on the diagnosis and treatment of these diseases.

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  1. Both authors contributed equally to this work.

Authors and Affiliations

  1. Jiangxi Research Institute of Ophthalmology and Visual Sciences, Affiliated Eye Hospital of Nanchang University, Nanchang, 330006, China

    Zhao-hui Ruan, Zi-xuan Xu, Xue-yun Zhou, Xian Zhang & Lei Shang

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  1. Zhao-hui Ruan
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  2. Zi-xuan Xu
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  3. Xue-yun Zhou
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  4. Xian Zhang
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  5. Lei Shang
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Additional information

This work was supported by grants from the Natural Science Foundation of Jiangxi Province (No. 20161bab215222), Educational Commission of Jiangxi Province of China (No. gjj150147) and Cultivation Scientific Research Fund for the Junior Teachers of Medicine in Nanchang University (No. py201826).

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The authors declare no potential conflicts of interest.

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Ruan, Zh., Xu, Zx., Zhou, Xy. et al. Implications of Necroptosis for Cardiovascular Diseases. CURR MED SCI 39, 513–522 (2019). https://doi.org/10.1007/s11596-019-2067-6

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