Skip to main content
Log in

Acrylamide in Thermally Processed Potato Products

  • Published:
Potato Research Aims and scope Submit manuscript

Abstract

High levels of acrylamide have been detected in French fries and potato crisps. The main pathway for acrylamide formation is from free asparagine and reducing sugars in the Maillard reaction. Asparagine provides the backbone of the acrylamide molecule. The rate of acrylamide formation increases significantly when asparagine is heated with carbonyl compounds such as reducing sugars. According to current knowledge, thermal load applied during processing in terms of temperature and duration has a significant influence on acrylamide formation in potato products depending on the concentrations of total reducing sugars and free asparagine in potato tubers. Glucose and fructose contents are generally regarded as a good indicator of the acrylamide forming potential of potato tubers. The latest regulation from the European Commission requires that food business operators take mitigation measures to lower the acrylamide content of their products below benchmark values. Therefore, efforts should be directed to reduce the amount of acrylamide formed in potato products. Excessive accumulation of acrylamide in potato products can be prevented during processing if the exposure of the product surface to high temperatures is limited. This is possible with temperature-programmed frying, which targets outer crust layers and cooked interiors for French fries. The same effect can be obtained by blanching potato strips in the microwave for a few seconds before deep frying. Combined technologies, such as partial baking followed by radio frequency post-drying, can also be used to control acrylamide formation during processing.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  • Amrein T, Bachmann S, Noti A, Biedermann M, Barbosa M, Biedermann-Brem S, Grob K, Keiser A, Relini P, Escher F, Amado R (2003) Potential of acrylamide formation, sugars, and free asparagine in potatoes: a comparison of cultivars and farming systems. J Agric Food Chem 51:5556–5560

    Article  CAS  PubMed  Google Scholar 

  • Amrein TM, Limacher A, Conde-Petit B, Amado R, Escher F (2006) Influence of thermal processing conditions on acrylamide generation and browning in a potato model system. J Agric Food Chem 54:5910–5916

    Article  CAS  PubMed  Google Scholar 

  • Becalski A, Lau BP-Y, Lewis D, Seaman S (2003) Acrylamide in foods: occurrence, sources and modeling. J Agric Food Chem 51:802–808

    Article  CAS  PubMed  Google Scholar 

  • Becalski A, Lau BPY, Lewis D, Seaman SW, Hayward S, Sahagian M, Ramesh M, Leclerc Y (2004) Acrylamide in French fries: influence of free amino acids and sugars. J Agric Food Chem 52:3801–3806

    Article  CAS  PubMed  Google Scholar 

  • Bethke PC, Bussan AJ (2013) Acrylamide in processed potato products. Am J Potato Res 90:403–424

    Article  CAS  Google Scholar 

  • Biedermann M, Grob K (2003) Model studies on acrylamide formation in potato, wheat flour and corn starch; ways to reduce acrylamide contents in bakery ware. Mitteilungen Aus Dem Gebeite Der Lebensmitteluntersuchung Und Hygiene 94:406–422

    CAS  Google Scholar 

  • Blank I, Robert F, Goldmann T, Pollien P, Varga N, Devaud S, Saucy F, Hyunh-Ba T, Stadler RH (2005) Mechanisms of acrylamide formation: Maillard-induced transformations of asparagine. In: Friedman M, Mottram DS (eds) Chemistry and safety of acrylamide in food. Springer, New York, pp 171–190

    Chapter  Google Scholar 

  • Bråthen E, Kita A, Knutsen SH, Wicklund T (2005) Addition of glycine reduces the content of acrylamide in cereal and potato products. J Agric Food Chem 53:3259–3264

    Article  PubMed  Google Scholar 

  • Chuda Y, Ono H, Yada H, Ohara-Takada A, Matsuura-Endo C, Mori M (2003) Effects of physiological changes in potato tubers (Solanum tuberosum L.) after low temperature storage on the level of acrylamide formed in potato chips. Biosci Biotechnol Biochem 67:1188–1190

    Article  CAS  PubMed  Google Scholar 

  • de Meulenaer B, de Wilde T, Mestdagh F, Govaert Y, Ooghe W, Fraselle S, Demeulemeester K, van Peteghem C, Calus A, Degroodt J-M, Verhe R (2008) Comparison of potato varieties between seasons and their potential for acrylamide formation. J Sci Food Agric 88:313–318

    Article  Google Scholar 

  • de Wilde T, de Meulenaer B, Mestdagh F, Govaert Y, Vandeburie S, Ooghe W, Fraselle S, Demeulemeester K, van Peteghem K, Calus A, Degroodt J, Verhe R (2005) Influence of storage practices on acrylamide formation during potato frying. J Agric Food Chem 53:6550–6557

    Article  PubMed  Google Scholar 

  • de Wilde T, de Meulenaer B, Mestdagh F, Govaert Y, Vandeburie S, Ooghe W, Fraselle S, Demeulemeester K, van Peteghem C, Calus A, Degroodt J-M, Verhe R (2006) Influence of fertilization on acrylamide formation during frying of potatoes harvested in 2003. J Agric Food Chem 54:404–408

    Article  PubMed  Google Scholar 

  • EFSA Panel on Contaminants in the Food Chain (CONTAM) (2015) Scientific opinion on acrylamide in food. EFSA J 13(6):4140

    Google Scholar 

  • Ehling S, Hengel M, Shibamoto T (2005) Formation of acrylamide from lipids. Adv Exp Med Biol 561:223–233

    Article  CAS  PubMed  Google Scholar 

  • Elmore J, Koutsidis G, Dodson A, Mottram D, Wedzicha B (2005) Measurement of acrylamide and its precursors in potato, wheat, and rye model systems. J Agric Food Chem 53:1286–1293

    Article  CAS  PubMed  Google Scholar 

  • Erdoğdu SB, Palazoğlu TK, Gökmen V, Şenyuva HZ, Ekiz I (2007) Reduction of acrylamide formation in French fries by microwave pre-cooking of potato strips. J Sci Food Agric 87:133–137

    Article  Google Scholar 

  • European Commission (2017) Commission Regulation (EU) 2017/2158 establishing mitigation measures and benchmark levels for the reduction of the presence of acrylamide in food. The OJEU 10:24–44

  • Franke K, Strijowski U, Reimerdes EH (2009) Kinetics of acrylamide formation in potato powder. J Food Eng 90:135–140

    Article  CAS  Google Scholar 

  • Friedman M (2003) Chemistry, biochemistry, and safety of acrylamide. A Review. J Agric Food Chem 51:4504–4526

    Article  CAS  PubMed  Google Scholar 

  • Gerendas J, Heuser F, Sattelmacher B (2007) Influence of nitrogen and potassium supply on contents of acrylamide precursors in potato tubers and on acrylamide accumulation in French fries. J Plant Nutr 30:1499–1516

  • Gökmen V, Palazoğlu TK (2008) Acrylamide formation in foods during thermal processing with a focus on frying. Food Bioprocess Technol 1:35–42

    Article  Google Scholar 

  • Gökmen V, Şenyuva HZ (2006a) A simplified approach for the kinetic characterization of acrylamide formation in fructose-asparagine model system. Food Addit Contam 23:348–354

    Article  PubMed  Google Scholar 

  • Gökmen V, Şenyuva HZ (2006b) Study of colour and acrylamide formation in coffee, wheat flour and potato chips during heating. Food Chem 99:238–243

    Article  Google Scholar 

  • Gökmen V, Şenyuva HZ (2007) Acrylamide formation is prevented by divalent cations during the Maillard reaction. Food Chem 103:196–203

    Article  Google Scholar 

  • Gökmen V, Palazoğlu TK, Şenyuva HZ (2006) Relation between the acrylamide formation and time–temperature history of surface and core regions of French fries. J Food Eng 77:972–976

    Article  Google Scholar 

  • Gökmen V, Kocadağlı T, Göncüoğlu MBA (2012) Model studies on the role of 5-hydroxymethyl-2-furfural in acrylamide formation from asparagine. Food Chem 132:168–174

    Article  PubMed  Google Scholar 

  • Granda C, Moreira R (2005) Kinetics of acrylamide formation during traditional and vacuum frying of potato chips. J Food Process Eng 28:478–493

    Article  Google Scholar 

  • Granda C, Moreira R, Tichy S (2004) Reduction of acrylamide formation in potato chips by low-temperature vacuum frying. J Food Sci 69:E405–E411

    Article  CAS  Google Scholar 

  • Granvogl M, Schieberle P (2006) Thermally generated 3-aminopropionamide as a transient intermediate in the formation of acrylamide. J Agric Food Chem 54:5933–5938

  • Haase NU, Matthaeus B, Vosmann K (2003) Acrylamide formation in foodstuffs-minimizing strategies for potato crisps. Deutsche Lebensmittel Rundschau 99:87–90

    CAS  Google Scholar 

  • Halford NG, Muttucumaru N, Powers SJ, Gillatt PN, Hartley L, Elmore JS, Mottram DS (2012) Concentrations of free amino acids and sugars in nine potato varieties: effects of storage and relationship with acrylamide formation. J Agric Food Chem 60:12044–12055

    Article  CAS  PubMed  Google Scholar 

  • Hamzalıoğlu A, Gökmen V (2020) 5-Hydroxymethylfurfural accumulation plays a critical role on acrylamide formation in coffee during roasting as confirmed by multiresponse kinetic modelling. Food Chem 318:126467

    Article  PubMed  Google Scholar 

  • IARC (1994) Acrylamide. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol. 60, Lyon France, pp. 389–433

  • Jung MY, Choi DS, Ju JW (2003) A novel technique for limitation of acrylamide formation in fried and baked corn chips and in French fries. J Food Sci 68:1287–1290

    Article  CAS  Google Scholar 

  • Knol JJ, Viklund GAI, Linssen JPH, Sjoholm IM, Skog KI, van Boekel MAJS (2008) A study on the use of empirical models to predict the formation of acrylamide in potato crisps. Mol Nutr Food Res 52:313–321

    Article  CAS  PubMed  Google Scholar 

  • Knol JJ, Linssen JPH, van Boekel MAJS (2010) Unravelling the kinetics of the formation of acrylamide in the Maillard reaction of fructose and asparagine by multiresponse modelling. Food Chem 120:1047–1057

    Article  CAS  Google Scholar 

  • Knutsen SH, Dimitrijevic S, Molteberg EL, Segtnan VH, Kaaber L, Wicklund T (2009) The influence of variety, agronomical factors and storage on the potential for acrylamide formation in potatoes grown in Norway. LWT-Food Sci Technol 42:550–556

    Article  CAS  Google Scholar 

  • Kuek SL, Tarmizi AHA, Razak RAA, Jinap S, Norliza S, Sanny M (2020) Contribution of lipid towards acrylamide formation during intermittent frying of French fries. Food Control 118:1–8

    Article  Google Scholar 

  • Lindsay RC, Jang S (2005) Chemical intervention strategies for substantial suppression of acrylamide formation in fried potato products. In Friedman M, Mottram D (eds) Chemistry and Safety of Acrylamide in Food. Springer- Verlag, Berlin, pp 393–404

  • Low MY, Koutsidis G, Parker JK, Elmore JS, Dodson AT, Mottram DS (2006) Effect of citric acid and glycine addition on acrylamide and flavor in a potato model system. J Agric Food Chem 54:5976–5983

    Article  CAS  PubMed  Google Scholar 

  • Matthäus B, Haase NU, Vosmann K (2004) Factors affecting the concentration of acrylamide during deep-fat frying of potatoes. Eur J Lipid Sci Technol 106:793–801

    Article  Google Scholar 

  • Mestdagh F, de Wilde T, Delporte K, van Peteghem C, de Meulenaer B (2008) Impact of chemical pre-treatments on the acrylamide formation and sensorial quality of potato crisps. Food Chem 106:914–922

    Article  CAS  Google Scholar 

  • Mills C, Mottram DS, Wedzicha BL (2009) Acrylamide. In: Stadler RH, Lineback DR (eds) Process-induced food toxicants. Wiley, Hoboken, pp 23–50

    Google Scholar 

  • Mottram DS, Wedzicha BI, Dodson AT (2002) Acrylamide is formed in the Maillard reaction. Nature 419:448–449

    Article  CAS  PubMed  Google Scholar 

  • Muttucumaru N, Powers SJ, Briddon A, Elmore JS, Mottram DS, Halford NG (2014) Evidence for the complex relationship between the concentrations of free amino acids, sugars and acrylamide-forming potential in potato. Ann Appl Biol 164:286–300

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Muttucumaru N, Powers SJ, Elmore JS, Dodson A, Briddon A, Mottram DS, Halford NG (2017) Acrylamide-forming potential of potatoes grown at different locations, and the ratio of free asparagine to reducing sugars at which free asparagine becomes a limiting factor for acrylamide formation. Food Chem 220:76–86

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ohara-Takada A, Matsuura-Endo C, Chuda Y, Ono H, Yada H, Yoshida M, Kobayashi A, Tsuda S, Takigawa S, Noda T, Yamauchi H, Mori M (2005) Change in content of sugars and free amino acids in potato tubers under short-term storage at low temperature and the effect on acrylamide level after frying. Biosci Biotechnol Biochem 69:1232–1238

    Article  CAS  PubMed  Google Scholar 

  • Palazoğlu TK, Gökmen V (2008a) Reduction of acrylamide level in French fries by employing a temperature program during frying. J Agric Food Chem 56:6162–6166

    Article  PubMed  Google Scholar 

  • Palazoğlu TK, Gökmen V (2008b) Development and experimental validation of a frying model to estimate acrylamide levels in French fries. J Food Sci 73:E109–E114

    Article  PubMed  Google Scholar 

  • Palermo M, Gökmen V, de Meulenaer B, Cieserova Z, Zhang Y, Pedreschi F, Fogliano V (2016) Acrylamide mitigation strategies: critical appraisal of the FoodDrinkEurope toolbox. Food Funct 7:2516–2525

    Article  CAS  PubMed  Google Scholar 

  • Parker JK, Balagiannis DP, Higley J, Smith G, Wedzicha BL, Mottram DS (2012) Kinetic model for the formation of acrylamide during the finish-frying of commercial French fries. J Agric Food Chem 60:9321–9331

    Article  CAS  PubMed  Google Scholar 

  • Pedrechi F, Moyano P, Kaack K, Granby K (2005) Color changes and acrylamide formation in fried potato slices. Food Res Int 38:1–9

    Article  Google Scholar 

  • Pedreschi F, Kaack K, Granby K, Troncoso E (2007) Acrylamide reduction under different pre-treatments in French fries. J Food Eng 79:1287–1294

    Article  CAS  Google Scholar 

  • Powers SJ, Mottram DS, Curtis A, Halford NG (2021) Progress on reducing acrylamide levels in potato crisps in Europe, 2002 to 2019. Food Additiv Contam: Part A 38(5):782–806

  • Raffan S, Halford NG (2019) Acrylamide in food: progress in and prospects for genetic and agronomic solutions. Ann Appl Biol 175:259–281

    Article  PubMed  PubMed Central  Google Scholar 

  • Rydberg P, Eriksson S, Tareke E, Karlsson P, Ehrenberg L, Törnqvist M (2003) Investigations of factors that influence the acrylamide content of heated foodstuffs. J Agric Food Chem 51:7012–7018

    Article  CAS  PubMed  Google Scholar 

  • Sanny M, Luning PA, Jinap S, Bakker EJ, van Boekel MAJS (2013) Effect of frying instructions for food handlers on acrylamide concentration in French fries: an explorative study. J Food Prot 76(3):462–472

    Article  CAS  PubMed  Google Scholar 

  • Schieberle P, Koehler P, Granvogl M (2005) New aspects on the formation and analysis of acrylamide. In: Friedman M, Mottram DS (eds) Chemistry and safety of acrylamide in food. Springer, New York, pp 205–222

    Chapter  Google Scholar 

  • Shepherd LVT, Bradshaw JE, Dale MFB, McNicol JW, Pont SDA, Mottram DS, Davies HV (2010) Variation in acrylamide producing potential in potato: segregation of the trait in a breeding population. Food Chem 123:568–573

    Article  CAS  Google Scholar 

  • Stadler RH, Studer A (2016) Acrylamide formation mechanisms. In: Gökmen V (ed) Acrylamide in food: analysis, content & potential health effects. Academic Press, Elsevier, Waltham, MA, pp 1–16

    Google Scholar 

  • Stadler R, Blank I, Varga N, Robert F, Hau J, Guy P, Robert M, Riediker S (2002) Acrylamide from Maillard reaction products. Nature 419:449–450

    Article  CAS  PubMed  Google Scholar 

  • Stadler RH, Robert F, Riediker S, Varga N, Davidek T, Devaud S, Goldmann T, Hau J, Blank I (2004) In-depth mechanistic study on the formation of acrylamide and other vinylogous compounds by the Maillard reaction. J Agric Food Chem 52:5550–5558

    Article  CAS  PubMed  Google Scholar 

  • Stark J, Love S (2003) Potato production systems. University of Idaho. Center for Potato Research and Education, University of Idaho. Extension

  • Surdyk N, Rosén J, Andersson R, Åman P (2004) Effects of asparagine, fructose, and baking conditions on acrylamide content in yeast-leavened wheat bread. J Agric Food Chem 52:2047–2051

    Article  CAS  PubMed  Google Scholar 

  • Tareke E, Rydberg P, Karlsson S, Eriksson M, Törnqvist M (2002) Analysis of acrylamide, a carcinogen formed in heated foodstuffs. J Agric Food Chem 50:4998–5006

    Article  CAS  PubMed  Google Scholar 

  • Wedzicha BL, Mottram DS, Elmose JS, Koutsidis G, Dodson AT (2005) Kinetic models as a route to control acrylamide formation in food. In: Friedman M, Mottram DS (eds) Chemistry and safety of acrylamide in food. Springer, New York, pp 235–253

    Chapter  Google Scholar 

  • Weisshaar R (2004) Acrylamide in heated potato products—analytics and formation routes. Eur J Lipid Sci Technol 106:786–792

    Article  CAS  Google Scholar 

  • Weisshaar R, Gutsche B (2002) Formation of acrylamide in heated potato products-model experiments pointing to asparagine as precursor. Dtsch Lebensm-Rundsch 98:397–400

    CAS  Google Scholar 

  • Whittaker A, Marotti I, Dinelli G, Calamai L, Romagnoli S, Manzelli M, Palchetti E, Vecchio V, Benedettelli S (2010) The influence of tuber mineral element composition as a function of geographical location on acrylamide formation in different Italian potato genotypes. J Sci Food Agric 90:1968–1976

    CAS  PubMed  Google Scholar 

  • Williams J (2005) Influence of variety and processing conditions on acrylamide levels in fried potato crisps. Food Chem 90:875–881

    Article  CAS  Google Scholar 

  • Yaylayan V-A, Wnorowski A, Perez-Locas C (2003) Why asparagine needs carbohydrates to generate acrylamide. J Agric Food Chem 51:1753–1757

    Article  CAS  PubMed  Google Scholar 

  • Yıldız A, Palazoğlu TK, Erdoğdu F (2007) Determination of heat and mass transfer parameters during frying of potato slices. J Food Eng 79:11–17

    Article  Google Scholar 

  • Zamora R, Hidalgo FJ (2008) Contribution of lipid oxidation products to acrylamide formation in model systems. J Agric Food Chem 56:6075–6780

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Ren YP, Zhao HM, Zhang Y (2007) Determination of acrylamide in Chinese traditional carbohydrate-rich foods using gas chromatography with micro-electron capture detector and isotope dilution liquid chromatography combined with electrospray ionization tandem mass spectrometry. Anal Chim Acta 584(2):322–332

    Article  CAS  PubMed  Google Scholar 

  • Zhu F, Cai YZ, Ke J, Corke H (2010) Compositions of phenolic compounds, amino acids and reducing sugars in commercial potato varieties and their effects on acrylamide formation. J Sci Food Agric 90:2254–2262

    Article  CAS  PubMed  Google Scholar 

  • Zyzak DV, Sanders RA, Stojanovic M, Tallmadge DH, Eberhart BL, Ewald DK, Gruber DC, Morsch TR, Strothers MA, Rizzi GP, Villagran MD (2003) Acrylamide formation mechanism in heated foods. J Agric Food Chem 51:4782–4787

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Vural Gökmen.

Ethics declarations

Competing Interests

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gökmen, V. Acrylamide in Thermally Processed Potato Products. Potato Res. 66, 1315–1329 (2023). https://doi.org/10.1007/s11540-023-09634-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11540-023-09634-8

Keywords

Navigation