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Exploring the Relationship between Quality of Life (EQ-5D) and Clinical Measures in Adult Attention Deficit Hyperactivity Disorder (ADHD)

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Abstract

Objective

To explore the association between quality of life (QoL) and clinical measures in patients with adult Attention Deficit Hyperactivity Disorder (ADHD); as well as assess the work impairment related to the disease.

Method

A cross-sectional study was conducted in an outpatient clinic of a university hospital in Hungary between 2011–2013 (n = 75). QoL was measured by the European Quality of Life-5 Dimensions questionnaire (EQ-5D). Associations between EQ-5D and clinical measures such as physician’s assessment on a visual analogue scale (physician-VAS), Clinical Global Impression-Severity scale (CGI-S), and Conners’ Adult ADHD Rating Scale (CAARS) subscores were assessed by Spearman-correlation and linear regression models. Productivity loss was estimated using the Work Productivity and Activity Impairment Questionnaire (WPAI) questionnaire.

Results

The mean EQ-5D index and EQ VAS scores were 0.74(SD = 0.22) and 69.5(SD = 19.4), significantly lower than the scores of the age-matched general population. Significant correlations were found between EQ-5D index and clinical measures. No correlation was found between CAARS and physician-VAS, CGI-S. The regression models explained 44.0 % of the EQ-5D index variance. The productivity loss was estimated to 47.5 %.

Conclusion

To our knowledge, this study is the first to analyze the relationship between EQ-5D and clinical measures in adult ADHD in real world practice. Significant correlation between EQ-5D and the clinical measures suggests that EQ-5D is a sensitive measure of the health impairment related to ADHD and psychiatric co-morbidities, thus it contributes to a better understanding of the burden of adult ADHD. The lack of association between the CAARS and physicians’ measures requires further research.

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Notes

  1. See: www.euroqol.org

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Aknowledgments

The authors are thankful to Lívia Balogh, Dóra Kovács, Anna Angyalosi who participated in the data collection.

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Authors and Affiliations

  1. Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary

    Attila J. Pulay, István Bitter & Szilvia Papp

  2. Department of Health Economics, Corvinus University of Budapest, Fővám tér 8., H-1093, Budapest, Hungary

    László Gulácsi, Márta Péntek, Valentin Brodszky, Fanni Rencz & Petra Baji

  3. Department of Rheumatology, Flór Ferenc County Hospital, Kistarcsa, Hungary

    Márta Péntek

  4. Faculty of Health Sciences, Semmelweis University, Budapest, Hungary

    Noémi V. Hevér

  5. Semmelweis University Doctoral School of Clinical Medicine, Budapest, Hungary

    Fanni Rencz

  6. CERGE-EI Fellow, Prague, Czech Republic

    Petra Baji

Authors
  1. Attila J. Pulay
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  2. István Bitter
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  3. Szilvia Papp
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  4. László Gulácsi
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  5. Márta Péntek
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  8. Fanni Rencz
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Correspondence to Márta Péntek.

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Pulay, A.J., Bitter, I., Papp, S. et al. Exploring the Relationship between Quality of Life (EQ-5D) and Clinical Measures in Adult Attention Deficit Hyperactivity Disorder (ADHD). Applied Research Quality Life 12, 409–424 (2017). https://doi.org/10.1007/s11482-016-9467-6

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