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Cytotoxicities of two new isoflavanes from the roots of Dalbergia velutina

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Abstract

Two new isoflavanes, dalvelutinanes A (1) and B (2), along with three known isoflavanes (3–5) were isolated from the roots of Dalbergia velutina. Their chemical structures, including their absolute configurations, were determined by spectroscopic analysis (1D and 2D NMR, HRESIMS, and CD). All isolated compounds were evaluated for their in vitro cytotoxicities against five human cancer cell lines (KB, HeLa-S3, MCF-7, HepG-2, and HT-29). Compound 5 showed significant cytotoxicity against all of the tested cancer cell lines, with IC50 values in the range 3.47–9.76 µM. In addition, compound 3 showed significant cytotoxicity against the KB and HeLa-S3 cells, with IC50 values of 8.29 and 9.54 µM, respectively, and compound 2 showed significant cytotoxicity against the MCF-7 cell line, with an IC50 value of 4.69 µM.

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Acknowledgments

The authors are grateful to the Graduate School of Chulalongkorn University for a postdoctoral fellowship (Ratchadaphiseksomphot Endowment Fund) to S.K. We also thank Dr. Suttira Khumkratok, Walai Rukhavej Botanical Research Institute, Mahasarakham University, Mahasarakham 44000, Thailand for the identification and deposition of the plant material.

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Authors and Affiliations

  1. Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand

    Sutin Kaennakam & Santi Tip-pyang

  2. Natural Products Research Section, Research Division, National Cancer Institute, Bangkok, 10400, Thailand

    Pongpun Siripong

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  1. Sutin Kaennakam
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  2. Pongpun Siripong
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  3. Santi Tip-pyang
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Correspondence to Santi Tip-pyang.

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Kaennakam, S., Siripong, P. & Tip-pyang, S. Cytotoxicities of two new isoflavanes from the roots of Dalbergia velutina . J Nat Med 71, 310–314 (2017). https://doi.org/10.1007/s11418-016-1039-4

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  • DOI: https://doi.org/10.1007/s11418-016-1039-4

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