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Effect of prenylated flavonoids and chalcones isolated from Artocarpus species on platelet aggregation in human whole blood

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Abstract

Five prenylflavonoids and two prenylchalcones from Artocarpus lowii King, A. scortechinii King and A. teysmanii Miq., and acetylated derivatives of cycloheterophyllin and artonin E were investigated for their ability to inhibit arachidonic acid (AA), collagen and adenosine diphosphate (ADP)-induced platelet aggregation in human whole blood by using an electrical impedance method. Among the tested compounds, only cycloheterophyllin inhibited AA-induced platelet aggregation with an IC50 value of 100.9 μM. It also showed strong inhibition against ADP-induced aggregation, with an IC50 value of 57.1 μM. Isobavachalcone, 2′,4′-dihydroxy-4-methoxy-3′-prenyldihydrochalcone, cycloartobiloxanthone, artonin E and artonin E triacetate showed selective inhibition against ADP-induced aggregation, with IC50 values ranging from 55.3 to 192.0 μM, but did not show such effect against other inducers.

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Acknowledgements

This work was supported by a grant (02-01-02-SF0012) from the Ministry of Science, Technology and Innovation, Malaysia.

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Authors and Affiliations

  1. Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia

    Ibrahim Jantan & Yusyila H. Mohd Yasin

  2. Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Skudai, Johore, Malaysia

    Shajarahtunnur Jamil, Hasnah Sirat & Norazah Basar

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  1. Ibrahim Jantan
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  2. Yusyila H. Mohd Yasin
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  3. Shajarahtunnur Jamil
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  4. Hasnah Sirat
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Correspondence to Ibrahim Jantan.

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Jantan, I., Mohd Yasin, Y.H., Jamil, S. et al. Effect of prenylated flavonoids and chalcones isolated from Artocarpus species on platelet aggregation in human whole blood. J Nat Med 64, 365–369 (2010). https://doi.org/10.1007/s11418-010-0410-0

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  • DOI: https://doi.org/10.1007/s11418-010-0410-0

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