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Left atrial appendage closure: a balanced management of the thromboembolic risk in patients with hemophilia and atrial fibrillation

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Abstract

Atrial fibrillation is the most common cardiac arrhythmia and is a major cause of embolic stroke. In patients at high bleeding risk such as those with hemophilia, the thromboembolic prevention is challenging. We herein present three patients affected by moderate to severe hemophilia and atrial fibrillation that were treated in our Institution between March 2018 and September 2019, with percutaneous left atrial appendage closure. In patients with relative or absolute contraindications to long-term anticoagulant therapy, the left atrial appendage closure could represent a reasonable strategy.

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Correspondence to Marco Toselli.

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All procedures performed in studies involving human participants were conducted in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study. The author/s confirm that written consent for submission and publication of this case report including image(s) and associated text has been obtained from the patients, when applicable, in line with COPE guidance.

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Toselli, M., Bosi, D., Benatti, G. et al. Left atrial appendage closure: a balanced management of the thromboembolic risk in patients with hemophilia and atrial fibrillation. J Thromb Thrombolysis 50, 668–673 (2020). https://doi.org/10.1007/s11239-020-02097-5

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