Skip to main content
Log in

Polymeric cryogels as a new family of macroporous and supermacroporous materials for biotechnological purposes

  • Review
  • Published:
Russian Chemical Bulletin Aims and scope

Abstract

The review is devoted to a specific kind of polymeric gels formed as a result of non-deep freezing of solutions or colloidal sols of the corresponding precursors. These materials are termed as cryogels. They possess a series of unique properties, first of all, the specific character of porosity (macroporous cryogels with the pore cross-section from tenth fractions of μm to ∼10 μm and supermacroporous (gigaporous) cryogels with pores of tens and hundreds of μm) and are attractive from the viewpoint of biotechnological implementation. Approaches to the preparation of the so-called “smart” composites based on the cryogels are considered. The use of various cryogels as carriers of immobilized biocatalysts (enzymes, cells), matrices for wide-porous affinity sorbents and immunosorbents, and spongy scaffolds for 3D culturing of animal cells is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. V. I. Lozinsky, Usp. Khim., 2002, 71, 559 [Russ. Chem. Rev., 2002, 71, 489 (Engl. Transl.)].

    Google Scholar 

  2. V. I. Lozinsky, A. S. Vakula, A. L. Zubov, Biotekhnologiya, 1992, 4, 5 [Sov. Biotechnol., 1992, 4, 4 (Engl. Transl.)].

    Google Scholar 

  3. S. D. Varfolomeyev, E. I. Rainina, V. I. Lozinsky, Pure Appl. Chem., 1992, 64, 1193.

    Google Scholar 

  4. V. I. Lozinsky, Doct. Sci. (Chem.) Thesis, A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, 1994, 682 pp. (in Russian).

    Google Scholar 

  5. V. I. Lozinsky, Usp. Khim., 1998, 67, 641 [Russ. Chem. Rev., 1998, 67, 573 (Engl. Transl.)].

    CAS  Google Scholar 

  6. V. I. Lozinsky, F. M. Plieva, Enzyme Microb. Technol., 1998, 23, 227.

    CAS  Google Scholar 

  7. V. I. Lozinsky, F. M. Plieva, I. Yu. Galaev, B. Mattiasson, Bioseparation, 2001, 10, 163.

    CAS  Google Scholar 

  8. V. I. Lozinsky, I. Yu. Galaev, F. M. Plieva, I. N. Savina, H. Jungvid, B. Mattiasson, Trends Biotechnol., 2003, 21, 445.

    CAS  Google Scholar 

  9. V. I. Lozinsky, Hemijska Industrija (Chemical Industry, Belgrade), 2004, 58, 111.

    Google Scholar 

  10. V. I. Lozinsky, Tez. dokl. XVIII Mendeleevskogo s’ezda po obshchei i prikladnoi khimii [Proc. XVIII Mendeleev Congress on General and Applied Chemistry] (Moscow, September 23–28, 2007), Moscow, 2007, 4, 475 (in Russian).

    Google Scholar 

  11. V. V. Korshak, M. I. Shtil’man, Polimery v protsessakh immobilizatsii i modifikatsii prirodnykh soedinenii [Polymers in Immobilization and Modification Processes of Natural Compounds], Nauka, Moscow, 1984, 261 pp. (in Russian).

    Google Scholar 

  12. N. S. Egorov, V. D. Samuilov, Biotekhnologiya [Biotechnology], Vysshaya Shkola, Moscow, 1987, Book 1, 159 pp. (in Russian).

    Google Scholar 

  13. Smart Polymers for Bioseparation and Bioprocessing, Ed. I. Galaev, B. Mattiasson, Taylor and Francis, London— New York, 2002, 292 pp.

    Google Scholar 

  14. L. A. Osterman, Khromatografiya belkov i nukleinovykh kislot [Chromatography of Proteins and Nucleic Acids], Nauka, Moscow, 1985, 536 pp. (in Russian).

    Google Scholar 

  15. I. V. Berezin, N. L. Klyachko, A. V. Levashov, K. Martinek, V. V. Mozhaev, Yu. L. Khmelтnitskii, Immobilizovannye fermenty [Immobilized Enzymes], Vysshaya Shkola, Moscow, 1987, 159 pp. (in Russian).

    Google Scholar 

  16. Immobilized Cells and Enzymes: A Practical Approach, Ed. J. Woodward, IRL Press, Oxford—Washington, 1985.

    Google Scholar 

  17. A. P. Sinitsyn, E. I. Rainina, V. I. Lozinsky, S. D. Spasov, Immobilizovannye kletki mikroorganizmov [Immobilized Cells of Microorganisms], Izd-vo Mosk. Gos. Univ. Moscow, 1994, 288 pp. (in Russian).

    Google Scholar 

  18. L. A. Osterman, Metody issledovaniya belkov i nukleinovykh kislot: elektroforez i ulтtratsentrifugirovanie [Methods for Investigation of Proteins and Nucleic Acids: Electrophoresis and Ultracentrifugation], Nauka, Moscow, 1981, 288 pp. (in Russian).

    Google Scholar 

  19. L. A. Osterman, Issledovanie biologicheskikh makromolekul elektrofokusirovaniem, immunoelektroforezom i radioizotopnymi metodami [Investigation of Biological Macromolecules by Electrofocusing, Immunoelectrophoresis, and Radioisotope Methods], Nauka, Moscow, 1983, 304 pp. (in Russian).

    Google Scholar 

  20. S. P. Papkov, Studneobraznoe sostoyanie polimerov [Gel-like State of Polymers], Khimiya, Moscow, 1974, 256 pp. (in Russian).

    Google Scholar 

  21. Authorтs Certificate USSR 1008214; Byul. Izobret. [Invention Bulletin], 1983, 12 (in Russian).

  22. Slovar’ inostrannykh slov [Dictionary of Foreign Words], Eds I. V. Lekhin, F. N. Petrov, GIINS, Moscow, 1955, 853 pp. (in Russian).

    Google Scholar 

  23. G. B. Sergeev, V. A. Batyuk, Usp. Khim., 1976, 45, 793 [Russ. Chem. Rev., 1976, 45, 391 (Engl. Transl.)].

    CAS  Google Scholar 

  24. V. I. Lozinsky, E. S. Vainerman, S. V. Rogozhin, Colloid Polymer Sci., 1982, 260, 776.

    Google Scholar 

  25. V. I. Lozinsky, G. F. Korotaeva, E. S. Vainerman, S. V. Rogozhin, Colloid Polymer Sci., 1984, 262, 617.

    Google Scholar 

  26. V. I. Lozinsky, T. O. Golovina, E. S. Vainerman, S. V. Rogozhin, Vysokomol. Soedin., Ser. A, 1989, 31, 334 [Polym. Sci. USSR, Ser. A, 1989, 31, 1983 (Engl. Transl.)].

    Google Scholar 

  27. V. I. Lozinsky, S. A. Morozova, E. S. Vainerman, E. F. Titova, M. I. Shtil’man, E. M. Belavtseva, S. V. Rogozhin, Acta Polymerica, 1989, 40, 8.

    Google Scholar 

  28. D. G. Gusev, V. I. Lozinsky, V. I. Bakhmutov, Eur. Polym. J., 1993, 29, 49.

    CAS  Google Scholar 

  29. R. Tanaka, T. Hatakeyama, H. Hatakeyama, Polymer Int., 1998, 45, 118.

    CAS  Google Scholar 

  30. L. G. Damshkaln, I. A. Simenel, V. I. Lozinsky, J. Appl. Polym. Sci., 1999, 74, 1978.

    CAS  Google Scholar 

  31. V. I. Lozinsky, T. O. Golovina, D. G. Gusev, Polymer, 2000, 41, 35.

    CAS  Google Scholar 

  32. V. I. Lozinsky, L. G. Damshkaln, C. R. T. Brown, I. T. Norton, Polymer Int., 2000, 49, 1434.

    CAS  Google Scholar 

  33. V. I. Lozinsky, L. G. Damshkaln, J. Appl. Polym. Sci., 2000, 77, 2017.

    CAS  Google Scholar 

  34. V. I. Lozinsky, L. G. Damshkaln, B. L. Shaskol’skii, T. A. Babushkina, I. N. Kurochkin, I. I. Kurochkin, Kolloidn. Zh., 2007, 69, 798 [Colloid J., 2007, 69, 747 (Engl. Transl.)].

    Google Scholar 

  35. V. I. Lozinsky, L. G. Damshkaln, I. N. Kurochkin, I. I. Kurochkin, Kolloidn. Zh., 2008, 70, 212 [Colloid J., 2008, 70, 189 (Engl. Transl.)].

    Google Scholar 

  36. V. I. Lozinsky, L. G. Damshkaln, K. O. Bloch, P. Vardi, N. V. Grinberg, T. V. Burova, V. Ya. Grinberg, J. Appl. Polym. Sci., 2008, 108, 3046.

    CAS  Google Scholar 

  37. O. Ariga, T. Yamakawa, H. Fujimatsu, Y. Sano, J. Ferment. Bioeng., 1989, 68, 293.

    CAS  Google Scholar 

  38. V. I. Lozinsky, F. M. Plieva, A. L. Zubov, Biotekhnologiya, 1995, 1–2, 32 [Russ. Biotechnol., 1995, 2, 1 (Engl. Transl.)].

    Google Scholar 

  39. M. J. Gordon, K. C. Chu, A. Margaritis, A. J. Martin, C. R. Ethier, B. K. Rutt, Biotechnol. Bioeng., 1999, 65, 459.

    CAS  Google Scholar 

  40. M. Szczesna, E. Galas, S. Bielecki, J. Mol. Catal. B, Enzym., 2001, 11, 671.

    CAS  Google Scholar 

  41. F. M. Plieva, E. I. Isaeva, V. I. Lozinsky, Biotekhnologiya, 1998, 5, 32 [Russ. Biotechnol., 1998, 10, 12 (Engl. Transl.)].

    Google Scholar 

  42. Pat. RF 2130069; Byul. Izobr. [Invention Bulletin], 1999, 13 (in Russian).

  43. F. M. Plieva, I. Y. Galaev, B. Mattiasson, J. Sep. Sci., 2007, 30, 1657.

    CAS  Google Scholar 

  44. M. Nambu, Kobunshi Ronbunshu, 1990, 47, 695.

    CAS  Google Scholar 

  45. Ch. M. Hassan, N. A. Peppas, Adv. Polym. Sci., 2000, 153, 37.

    CAS  Google Scholar 

  46. Pat. Jpn 47-012854; Chem. Abstr., 1972, 77, 153121.

  47. Pat. USA 3875302; Chem. Abstr., 1972, 77, 62982.

    Google Scholar 

  48. M. M. Kukharchik, N. K. Baramboim, Vysokomol. Soedin., Ser. B, 1972, 14, 843 [Polym. Sci. USSR, Ser. B, 1972, 14 (Engl. Transl.)].

    CAS  Google Scholar 

  49. N. A. Peppas, Makromol. Chem., 1975, 176, 3433.

    CAS  Google Scholar 

  50. N. A. Peppas, S. R. Stauffer, J. Contr. Release, 1991, 16, 305.

    CAS  Google Scholar 

  51. V. I. Lozinsky, Proc. 1st Int. Symp. “Preparation and Application of Advanced Poly(vinyl alcohol),” Kyongsan (S. Korea), 2003, 38.

  52. V. I. Lozinsky, E. S. Vainerman, A. L. Zubov, V. K. Kulakova, S. V. Rogozhin, Biotekhnologiya, 1990, 5, 32 [Sov. Biotechnol., 1990, 5 (Engl. Transl.)].

    Google Scholar 

  53. V. I. Lozinsky, A. L. Zubov, V. K. Kulakova, E. F. Titova, S. V. Rogozhin, J. Appl. Polym. Sci., 1992, 44, 1423.

    Google Scholar 

  54. V. I. Lozinsky, A. L. Zubov, E. I. Titova, Enzyme Microb. Technol., 1997, 20, 182.

    CAS  Google Scholar 

  55. V. I. Lozinsky, L. G. Damshkaln, J. Appl. Polym. Sci., 2001, 82, 1609.

    CAS  Google Scholar 

  56. V. I. Lozinsky, I. N. Savina, Kolloidn. Zh., 2002, 64, 372 [Colloid J., 2002, 64, 336 (Engl. Transl.)].

    Google Scholar 

  57. I. N. Savina, V. I. Lozinsky, Kolloidn. Zh., 2004, 66, 388 [Colloid J., 2004, 66, 343 (Engl. Transl.)].

    Google Scholar 

  58. I. N. Savina, A. Hanora, F. M. Plieva, I. Yu. Galaev, B. Mattiasson, V. I. Lozinsky, J. Appl. Polym. Sci., 2005, 95, 529.

    CAS  Google Scholar 

  59. V. I. Lozinsky, L. G. Damshkaln, I. N. Kurochkin, I. I. Kurochkin, Kolloidn. Zh., 2005, 67, 649 [Colloid J., 2005, 67, 589 (Engl. Transl.)].

    Google Scholar 

  60. P. Yusong, X. Dangsheng, C. Xiaolin, J. Mater. Sci., 2007, 42, 5129.

    Google Scholar 

  61. E. Goiti, M. M. Salinas, G. Arias, D. Puglia, J. M. Kenny, C. Mijangos, Polymer Degradation and Stability, 2007, 92, 2198.

    CAS  Google Scholar 

  62. Pat. RF 2190644; Byul. Izobr. [Invention Bulletin], 2002, 28 (in Russian).

  63. K. Yao, J. Yun, Sh. Shen, L. Wang, X. He, X. Yu, J. Chromatogr. A, 2006, 1109, 103.

    CAS  Google Scholar 

  64. E. Kokufuta, E. Jinbo, Macromolecules, 1992, 25, 3549.

    CAS  Google Scholar 

  65. S. D. Varfolomeyev, E. I. Rainina, V. I. Lozinsky, Indian J. Chem., Sect. B, 1993, 32, 202.

    Google Scholar 

  66. T. Yamauchi, E. Kokufuta, Y. Osada, Polymer Gels Networks, 1993, 1, 247.

    CAS  Google Scholar 

  67. S. M. Gautier, P. E. Phillippe, L. J. Blum, Anal. Lett., 1994, 27, 2055.

    CAS  Google Scholar 

  68. L. Doretti, D. Ferrara, P. Gattolin, S. Lora, Talanta, 1997, 44, 859.

    CAS  Google Scholar 

  69. M. I. Shtil’man, S. N. Zhavoronkov, M. Yu. Yarmysh, P. S. Voskanyan, A. M. Tsatsakis, Zh. Prikl. Khim., 1999, 72, 1001 [Russ. J. Appl. Chem., 1999, 72, 1051 (Engl. Transl.)].

    CAS  Google Scholar 

  70. F. M. Veronese, C. Mammucari, P. Caliceti, F. Schiavon, S. Lora, J. Bioact. Compat. Polym., 1999, 14, 315.

    CAS  Google Scholar 

  71. A. V. Bacheva, F. M. Plieva, E. N. Lysogorskaya, I. Yu. Filippova, V. I. Lozinsky, Bioorg. Med. Chem. Lett., 2001, 11, 1005.

    CAS  Google Scholar 

  72. Yu. N. Belokon, K. A. Kochetkov, F. M. Plieva, N. S. Ikonnikov, V. I. Maleev, V. S. Parmar, R. Kumar, V. I. Lozinsky, Appl. Biochem. Biotechnol., 2000, 88, 97.

    CAS  Google Scholar 

  73. F. M. Plieva, K. A. Kochetkov, I. Singh, V. S. Parmar, Yu. N. Belokon, V. I. Lozinsky, Biotechnol. Lett., 2000, 22, 551.

    CAS  Google Scholar 

  74. B. Orlich, E. Kempin, K.-H. Reichert, R. Schomacker, Chemie Ing. Technik, 2000, 72, 1209.

    CAS  Google Scholar 

  75. I. Yu. Filippova, A. V. Bacheva, O. V. Baibak, F. M. Plieva, E. N. Lysogorskaya, E. S. Oksenoit, V. I. Lozinsky, Izv. Akad. Nauk, Ser. Khim., 2001, 1811 [Russ. Chem. Bull., Int. Ed., 2001, 50, 1896].

  76. E. Efremenko, V. Lozinsky, V. Sergeeva, F. Plieva, T. Makhlis, G. Kazankov, A. Gladilin, S. Varfolomeyev, J. Biochem. Biophys. Meth., 2002, 51, 195.

    CAS  Google Scholar 

  77. A. V. Bacheva, O. V. Baibak, A. V. Belyaeva, E. N. Lysogorskaya, E. S. Oksenoit, V. I. Lozinsky, I. Yu. Filippova, Bioorgan. Khim., 2003, 29, 551 [Russ. J. Bioorg. Chem., 2003, 29, 502 (Engl. Transl.)].

    CAS  Google Scholar 

  78. A. V. Bacheva, O. V. Baibak, A. V. Belyaeva, E. S. Oksenoit, T. I. Velichko, E. N. Lysogorskaya, A. K. Gladilin, V. I. Lozinsky, I. Yu. Filippova, Biokhimiya, 2003, 68, 1567 [Biochemistry (Moscow), 2003, 68, 1261 (Engl. Transl.)].

    Google Scholar 

  79. A. V. Bacheva, A. V. Belyaeva, E. N. Lysogorskaya, E. S. Oksenoit, V. I. Lozinsky, I. Yu. Filippova, J. Mol. Catal. B, Enzym., 2005, 32, 253.

    CAS  Google Scholar 

  80. A. V. Belyaeva, A. V. Bacheva, E. S. Oksenoit, E. N. Lysogorskaya, V. I. Lozinsky, I. Yu. Filippova, Bioorgan. Khim., 2005, 31, 586 [Russ. J. Bioorg. Chem., 2005, 31, 529 (Engl. Transl.)].

    Google Scholar 

  81. E. A. Markvicheva, V. I. Lozinsky, F. M. Plieva, K. A. Kochetkov, L. D. Rumsh, V. P. Zubov, J. Maity, R. Kumar, V. Parmar, Yu. N. Belokon, Pure Appl. Chem., 2005, 77, 227.

    CAS  Google Scholar 

  82. E. N. Lysogorskaya, T. V. Roslyakova, A. V. Belyaeva, A. V. Bacheva, V. I. Lozinsky, I. Yu. Filippova, Prikl. Biokhim. Mikrobiol., 2008, 44, 270 [Appl. Biochem. Microbiol., 2008, 44, 241 (Engl. Transl.)].

    Google Scholar 

  83. F. M. Plieva, Ph. D. (Chem.) Thesis, A. N. Nesmeyanov Institute of Organoelement Chemistry, Russian Academy of Sciences, Moscow, 1997, 139 pp. (in Russian).

    Google Scholar 

  84. I. Yu. Filippova, E. N. Lysogorskaya, A. V. Bacheva, V. I. Lozinsky, Tez. dokl. XVIII Mendeleevskogo s’ezda po obshchei i prikladnoi khimii [Proc. XVIII Mendeleev Congress on General and Applied Chemistry] (Moscow, September 23–28, 2007), Moscow, 2007, 4, 490 (in Russian).

    Google Scholar 

  85. Pat. RF 2233327; Byul. Izobr., 2004, 21 (in Russian).

  86. Y. E. Schapiro, E. G. Pykhteeva, A. V. Levashov, J. Colloid Interface Sci., 1998, 206, 168.

    Google Scholar 

  87. Y.-C. Tsai, J.-D. Huang, C.-C. Chiu, Biosensors Bioelectronics, 2007, 22, 3051.

    CAS  Google Scholar 

  88. V. I. Lozinsky, Proc. 1st Int. Symp. “Preparation of Functional Polymer Gels,” Kyoungsan (S. Korea), 2005, 113.

  89. V. I. Lozinsky, A. L. Zubov, T. A. Makhlis, in Immobilized Cells: Basics and Applications, Eds R. H. Wijffels, R. M. Buitelaar, C. Bucke, J. Tramper, Elsevier Sci. B.V., Amsterdam, 1996, 112.

    Google Scholar 

  90. Author’s Certificate USSR 1400071; Byul. Izobr., 1988, 20 (in Russian).

  91. R. Zh. Manolov, I. M. Tavobilov, V. I. Lozinsky, E. S. Vainerman, E. F. Titova, E. M. Belavtseva, S. I. Bezborodova, S. V. Rogozhin, A. M. Bezborodov, Prikl. Biokhim. Mikrobiol., 1988, 24, 514 [Appl. Biochem. Microbiol., 1988, 24 (Engl. Transl.)].

    CAS  Google Scholar 

  92. Pat. RF 2253677; Byul. Izobr., 2005, 16 (in Russian).

  93. Pat. RF 2315102; Byul. Izobr., 2008, 2 (in Russian).

  94. Pat. RF 2036095; Byul. Izobr., 1992, 15 (in Russian).

  95. Pat. RF 2104866; Byul. Izobr., 1998, 5 (in Russian).

  96. F. Yokoyama, I. Masada, K. Shimamura, T. Ikawa, K. Monobe, Colloid Polymer Sci., 1986, 264, 595.

    CAS  Google Scholar 

  97. C. M. Hassan, J. H. Ward, N. A. Peppas, Polymer, 2000, 41, 6729.

    CAS  Google Scholar 

  98. R. Ricciardi, C. Gaillet, G. Ducouret, F. Lafuma, F. Laupretre, Polymer, 2003, 44, 3375.

    CAS  Google Scholar 

  99. V. I. Lozinsky, A. L. Zubov, E. F. Titova, Enzyme Microb. Technol., 1996, 18, 561.

    CAS  Google Scholar 

  100. V. I. Lozinsky, A. L. Zubov, E. F. Titova, J. Appl. Polym. Sci., 1996, 61, 1991.

    CAS  Google Scholar 

  101. V. I. Lozinsky, E. S. Vainerman, L. V. Domotenko, A. M. Mamtsis, E. F. Titova, E. M. Belavtseva, S. V. Rogozhin, Colloid Polymer Sci., 1986, 264, 19.

    CAS  Google Scholar 

  102. L. V. Domotenko, V. I. Lozinsky, E. S. Vainerman, S. V. Rogozhin, Vysokomol. Soedin., Ser. A, 1988, 30, 1661 [Polym. Sci. USSR, Ser. A, 1988, 30, 1758 (Engl. Transl.)].

    CAS  Google Scholar 

  103. V. I. Lozinsky, E. S. Vainerman, L. V. Domotenko, A. L. Blyumenfel’d, V. V. Rogov, E. N. Barkovskaya, E. I. Fedin, S. V. Rogozhin, Kolloidn. Zh., 1989, 51, 685 [Colloid J. USSR, 1989, 51, 592 (Engl. Transl.)].

    Google Scholar 

  104. V. I. Lozinsky, L. V. Domotenko, E. S. Vainerman, S. V. Rogozhin, Vysokomol. Soedin., Ser. A, 1989, 31, 1805 [Polym. Sci. USSR, Ser. A, 1989, 31, 1983 (Engl. Transl.)].

    Google Scholar 

  105. L. G. Damshkaln, I. A. Simenel, V. I. Lozinsky, J. Appl. Polym. Sci., 1999, 74, 1978.

    CAS  Google Scholar 

  106. V. I. Lozinsky, A. L. Zubov, I. N. Savina, F. M. Plieva, J. Appl. Polym. Sci., 2000, 77, 1822.

    CAS  Google Scholar 

  107. V. I. Lozinsky, L. V. Domotenko, E. S. Vainerman, A. M. Mamtsis, S. V. Rogozhin, Polymer Bulletin, 1986, 15, 333.

    Google Scholar 

  108. Author’s Certificate USSR 1351971; Byul. Izobr., 1987, 42 (in Russian).

  109. V. I. Lozinsky, N. G. Faleev, A. L. Zubov, S. B. Ruvinov, T. A. Antonova, E. S. Vainerman, V. M. Belikov, S. V. Rogozhin, Biotechnol. Lett., 1989, 11, 43.

    Google Scholar 

  110. G. P. Alebyan, E. N. Arzumanov, M. B. Mkrtchan, P. V. Tozalakyan, V. I. Lozinsky, E. S. Vainerman, S. V. Rogozhin, Biotekhnologiya, 1990, 6, 29 [Sov. Biotechnol., 1990, 6, 36 (Engl. Transl.)].

    Google Scholar 

  111. V. V. Fokina, A. Yu. Arinbasarova, A. L. Zubov, V. I. Lozinsky, K. A. Koshcheenko, Prikl. Biokhim. Mikrobiol., 1995, 31, 213 [Appl. Biochem. Microbiol., 1995, 31, 184 (Engl. Transl.)].

    CAS  Google Scholar 

  112. V. Fokina, N. Susina, A. Arinbasarova, A. Zubov, V. Lozinsky, K. Koshcheenko, in Immobilized Cells: Basics and Applications, Eds R. H. Wijffels, R. M. Buitelaar, C. Bucke, J. Tramper, Elsevier Sci. B.V., Amsterdam, 1996, 90.

    Google Scholar 

  113. N. A. Stepanov, O. V. Sen’ko, A. A. Skomarovskii, V. I. Lozinsky, E. N. Efremenko, A. P. Sinitsyn, S. D. Varfolomeev, Tez. dokl. XVIII Mendeleevskogo s’ezda po obshchei i prikladnoi khimii [Proc. XVIII Mendeleev Congress on General and Applied Chemistry] (Moscow, September 23–28, 2007), Moscow, 2007, 4, 587 (in Russian).

    Google Scholar 

  114. S. Gough, N. Barron, A. L. Zubov, V. I. Lozinsky, A. P. McHale, Bioprocess Eng., 1989, 19, 87.

    Google Scholar 

  115. Pat. RF 2239658; Byul. Izobr., 2004, 31 (in Russian).

  116. N. N. Martynenko, I. M. Gracheva, N. G. Sarishvili, A. L. Zubov, G. I. El’-Registan, V. I. Lozinsky, Prikl. Biokhim. Mikrobiol., 2004, 40, 186 [Appl. Biochem. Microbiol., 2004, 40, 158 (Engl. Transl.)].

    CAS  Google Scholar 

  117. S. D. Varfolomeev, E. I. Rainina, V. I. Lozinsky, S. B. Kalyuzhnyi, A. P. Sinitsyn, T. A. Makhlis, G. P. Bachurina, I. G. Bokova, O. A. Sklyankina, E. V. Agafonov, in Physiology of Immobilized Cells, Eds J. A. M. de Bont, J. Visser, B. Mattiasson, J. Tramper, Elsevier, Wageningen, 1989, 325.

    Google Scholar 

  118. O. A. Nikitina, S. S. Zatsepin, S. V. Kalyuzhnyi, E. I. Rainina, S. D. Varfolomeev, A. L. Zubov, V. I. Lozinsky, Mikrobiologiya, 1993, 62, 477 [Microbiology, 1993, 62, 296 (Engl. Transl.)].

    CAS  Google Scholar 

  119. E. I. Rainina, M. A. Pusheva, A. M. Ryabokon’, N. P. Bolotina, V. I. Lozinsky, S. D. Varfolomeyev, Biotechnol. Appl. Biochem., 1994, 14, 321.

    Google Scholar 

  120. A. M. Ryabokon’, M. V. Kevbrina, M. A. Pusheva, A. L. Zubov, V. I. Lozinsky, E. A. Rainina, in Immobilized Cells: Basics and Applications, Eds R. H. Wijffels, R. M. Buitelaar, C. Bucke, J. Tramper, Elsevier Sci. B.V., Amsterdam, 1996, 106.

    Google Scholar 

  121. Pat. RF 2080388; Byul. Izobr., 1997, 15 (in Russian).

  122. S. Velizarov, E. I. Rainina, V. I. Lozinsky, A. L. Zubov, A. P. Sinitsyn, S. D. Varfolomeyev, Biotechnol. Lett., 1992, 14, 291.

    CAS  Google Scholar 

  123. E. N. Efremenko, O. V. Spiricheva, D. V. Veremeenko, V. I. Lozinsky, Hemijska Industrija (Chemical Industry, Belgrade), 2004, 58, 116.

    Google Scholar 

  124. Pat. RF 2253677; Byul. Izobr., 2005, 16 (in Russian).

  125. E. N. Efremenko, O. V. Spiricheva, D. V. Veremeenko, A. V. Baibak, V. I. Lozinsky, J. Chem. Technol. Biotechnol., 2006, 81, 519.

    CAS  Google Scholar 

  126. E. Efremenko, O. Spiricheva, S. Varfolomeyev, V. Lozinsky, Appl. Microbiol. Biotechnol., 2006, 72, 480.

    CAS  Google Scholar 

  127. Author’s Certificate USSR 1505972; Byul. Izobr., 1989, 33 (in Russian).

  128. L. V. Belousova, V. I. Lozinsky, E. S. Vainerman, S. V. Rogozhin, S. N. Egorov, N. S. Egorov, in Fermenty mikroorganizmov [Enzymes of Microorganisms], Izd-vo VNIISENTI, Moscow, 1989, Chapter II, 224 (in Russian).

    Google Scholar 

  129. O. V. Sen’ko, O. V. Spiricheva, V. I. Lozinsky, E. N. Efremenko, Kataliz v promyshlennosti [Catalysis in Industry], 2007, 1, 55 (in Russian).

    Google Scholar 

  130. Pat. RF 2315102; Byul. Izobr., 2008, 2 (in Russian).

  131. E. Efremenko, O. Senko, D. Zubaerova, E. Podorozhko, V. Lozinsky, Food Technol. Biotechnol., 2008 46, 206.

    Google Scholar 

  132. C. J. Cunningham, I. B. Ivshina, V. I. Lozinsky, M. S. Kuyukina, J. C. Philp, Int. Biodeterioration and Biodegradation, 2004, 54, 167.

    CAS  Google Scholar 

  133. M. S. Kuyukina, I. B. Ivshina, A. Yu. Gavrin, E. A. Podorozhko, V. I. Lozinsky, C. E. Jeffree, J. C. Philp, J. Microbiol. Meth., 2006, 65, 596.

    CAS  Google Scholar 

  134. A. L. Simonian, E. I. Rainina, V. I. Lozinsky, I. E. Badalian, G. A. Khachatrian, S. Sh. Tatikian, T. A. Makhlis, S. D. Varfolomeyev, Appl. Biochem. Biotechnol., 1992, 36, 199.

    CAS  Google Scholar 

  135. L. Brovko, N. Romanova, T. Makhlis, A. Zubov, V. Lozinsky, N. Ugarova, Proc. Int. Workshop «ioencapsulation VI», Eds F. Godia, D. Poncelet, Barcelona Autonomous University Publ., Barcelona, 1997, T3.4/1–4.

    Google Scholar 

  136. M. Okazaki, T. Hamada, H. Fujii, A. Mizobe, S. Matsuzawa, J. Appl. Polym. Sci., 1995, 58, 2235.

    CAS  Google Scholar 

  137. M. Okazaki, T. Hamada, H. Fujii, O. Kusuodo, A. Mizobe, S. Matsuzawa, J. Appl. Polym. Sci., 1995, 58, 2243.

    CAS  Google Scholar 

  138. Pat. RF 2220987; Byul. Izobr., 2004, 1 (in Russian).

  139. S. V. Rogozhin, V. I. Lozinsky, E. S. Vainerman, V. V. Korshak, Dokl. Akad. Nauk SSSR, 1983, 273, 1140 [Dokl. Chem., 1983 (Engl. Transl.)].

    CAS  Google Scholar 

  140. V. I. Lozinsky, E. S. Vainerman, E. F. Titova, E. M. Belavtseva, S. V. Rogozhin, Colloid Polymer Sci., 1984, 262, 769.

    Google Scholar 

  141. E. M. Belavtseva, E. F. Titova, V. I. Lozinsky, E. S. Vainerman, S. V. Rogozhin, Colloid Polymer Sci., 1984, 262, 775.

    CAS  Google Scholar 

  142. V. I. Lozinsky, E. S. Vainerman, S. A. Ivanova, E. F. Titova, M. I. Shtilman, E. M. Belavtseva, S. V. Rogozhin, Acta Polymerica, 1986, 37, 142.

    CAS  Google Scholar 

  143. V. I. Lozinsky, E. A. Kalinina, V. Ya. Grinberg, N. V. Grinberg, V. V. Chupov, N. A. Plate, Vysokomol. Soedin., Ser. A, 1997, 39, 1972 [Polym. Sci., Ser. A, 1997, 39, 1300 (Engl. Transl.)].

    Google Scholar 

  144. E. S. Vainerman, V. I. Lozinsky, S. V. Rogozhin, Colloid Polymer Sci., 1981, 259, 1198.

    CAS  Google Scholar 

  145. S. V. Rogozhin, E. S. Vainerman, V. I. Lozinsky, Dokl. Akad. Nauk SSSR, 1982, 263, 115 [Dokl. Chem., 1982 (Engl. Transl.)].

    CAS  Google Scholar 

  146. Pat. RF 2008362; Byul. Izobr., 1994, 4 (in Russian).

  147. Pat. RF 2053796; Byul. Izobr., 1996, 4 (in Russian).

  148. R. V. Ivanov, V. I. Lozinsky, S. K. Noh, S. S. Han, W. S. Lyoo, J. Appl. Polym. Sci., 2007, 106, 1470.

    CAS  Google Scholar 

  149. R. V. Ivanov, V. I. Lozinsky, S. K. Noh, Y. R. Lee, S. S. Han, W. S. Lyoo, J. Appl. Polym. Sci., 2008, 107, 382.

    CAS  Google Scholar 

  150. Author’s Certificate USSR 1171474; Byul. Izobr., 1985, 29 (in Russian).

  151. Author’s Certificate USSR 1171476; Byul. Izobr., 1985, 29 (in Russian).

  152. Pat. 2035476 RF; Byul. Izobr., 1995, 14 (in Russian).

  153. Pat. 2078099 RF; Byul. Izobr., 1997, 12 (in Russian).

  154. S. V. Rogozhin, V. I. Lozinsky, E. S. Vainerman, L. V. Domotenko, A. M. Mamtsis, S. A. Ivanova, M. I. Shtil’man, V. V. Korshak, Dokl. Akad. Nauk SSSR, 1984, 278, 129 [Dokl. Chem., 1984 (Engl. Transl.)].

    CAS  Google Scholar 

  155. Pat. RF 2058083; Byul. Izobr., 1996, 11 (in Russian).

  156. N. R. Konstantinova, V. I. Lozinsky, Food Hydrocolloids, 1997, 11, 113.

    CAS  Google Scholar 

  157. Pat. RF 2116801; Byul. Izobr., 1998, 22 (in Russian).

  158. Pat. RF 2118495; Byul. Izobr., 1998, 25 (in Russian).

  159. E. A. Podorozhko, E. A. Kurskaya, V. K. Kulakova, V. I. Lozinsky, Food Hydrocolloids, 2000, 14, 111.

    CAS  Google Scholar 

  160. P. Arvidsson, F. M. Plieva, V. I. Lozinsky, I. Yu. Galaev, B. Mattiasson, J. Chromatogr. A, 2003, 986, 275.

    CAS  Google Scholar 

  161. J. Yun, S. Shen, F. Chen, K. Yao, J. Chromatogr. B, 2007, 860, 57.

    CAS  Google Scholar 

  162. J. Ahlqvist, A. Kumar, H. Sundström, E. Ledung, E. Gunnar-Hörnsten, S.-O. Enfors, B. Mattiasson, J. Biotechnol., 2006, 122, 216.

    CAS  Google Scholar 

  163. S. L. Williams, M. E. Eccleston, N. K. H. Slater, Biotechnol. Bioeng., 2005, 89, 783.

    CAS  Google Scholar 

  164. M. Teilum, M. J. Hansson, M. B. Dainiak, R. Mansson, S. Surve, E. Elmer, G. Mattiasson, Anal. Biochem., 2006, 348, 209.

    CAS  Google Scholar 

  165. P. Arvidsson, F. M. Plieva, I. N. Savina, V. I. Lozinsky, S. Fexby, L. Bulow, I. Yu. Galaev, B. Mattiasson, J. Chromatogr. A, 2002, 977, 27.

    CAS  Google Scholar 

  166. A. Kumar, F. M. Plieva, I. Yu. Galaev, B. Mattiasson, J. Immunol. Meth., 2003, 283, 185.

    CAS  Google Scholar 

  167. V. I. Lozinsky, M. N. Korneeva, E. S. Vainerman, S. V. Rogozhin, Dokl. Akad. Nauk SSSR, 1983, 270, 101 [Dokl. Chem., 1983 (Engl. Transl.)].

    Google Scholar 

  168. M. B. Dainiak, I. Yu. Galaev, A. Kumar, F. M. Plieva, B. Mattiasson, Adv. Biochem. Eng./Biotechnol., 2007, 106, 101.

    CAS  Google Scholar 

  169. V. I. Lozinsky, R. V. Ivanov, E. V. Kalinina, G. I. Timofeeva, A. R. Khokhlov, Macromol. Rap. Commun., 2001, 22, 1441.

    CAS  Google Scholar 

  170. Pat. RF 2196780; Byul. Izobr., 2003, 2 (in Russian).

  171. V. I. Lozinsky, R. V. Ivanov, in Sintez i modifikatsiya polimerov [Synthesis and Modification of Polymers], Ed. Yu. B. Monakov, Khimiya, Moscow, 2003, 68 (in Russian).

    Google Scholar 

  172. R. V. Ivanov, T. A. Babushkina, V. I. Lozinsky, Vysokomol. Soedin., Ser. A, 2005, 47, 1418 [Polym. Sci., Ser. A, 2005, 47, 791 (Engl. Transl.)].

    CAS  Google Scholar 

  173. R. V. Ivanov, V. I. Lozinsky, Vysokomol. Soedin., Ser. A, 2006, 48, 2092 [Polym. Sci., Ser. A, 2006, 48, 1232 (Engl. Transl.)].

    CAS  Google Scholar 

  174. I. Lyagin, R. Ivanov, V. Lozinsky, E. Efremenko, Proc. Int. Workshop “Bioencapsulation XV,” Ed. H. Vierstein, University of Vienna Publ., Vienna, 2007, P2–13(1–4).

    Google Scholar 

  175. M. B. Dainiak, F. M. Plieva, I. Yu. Galaev, R. Hatti-Kaul, B. Mattiasson, Biotechnol. Progr., 2005, 21, 664.

    Google Scholar 

  176. E. Efremenko, Y. Votchitseva, F. Plieva, I. Galaev, B. Mattiasson, Appl. Microbiol. Biotechnol., 2006, 70, 558.

    CAS  Google Scholar 

  177. J. Porath, J. Carlsson, I. Olsson, G. Belfrage, Nature, 1975, 258, 598.

    CAS  Google Scholar 

  178. K. A. Lusta, N. G. Starostina, N. B. Gorkina, B. A. Fikhte, V. I. Lozinsky, E. S. Vainerman, S. V. Rogozhin, Prikl. Biokhim. Mikrobiol., 1988, 24, 504 [Appl. Biochem. Microbiol., 1988, 24 (Engl. Transl.)].

    CAS  Google Scholar 

  179. O. I. Slabova, D. I. Nikitin, V. I. Lozinsky, E. S. Vainerman, S. V. Rogozhin, Mikrobiologiya, 1991, 60, 23 [Microbiology, 1991, 60, 14 (Engl. Transl.)].

    CAS  Google Scholar 

  180. K. A. Lusta, I. K. Chung, I. W. Sul, H. S. Park, D. I. Shin, Proc. Biochem., 2000, 35, 1177.

    CAS  Google Scholar 

  181. O. I. Slabova, D. I. Nikitin, V. I. Lozinsky, V. K. Kulakova, E. S. Vainerman, S. V. Rogozhin, Mikrobiologiya, 1988, 57, 940 [Microbiology, 1988, 57, 749 (Engl. Transl.)].

    CAS  Google Scholar 

  182. A. Kumar, V. Bansal, K. S. Nandakumar, I. Yu. Galaev, P. K. Roychoudhury, R. Holmdahl, B. Mattiasson, Biotechnol. Bioeng., 2006, 93, 636.

    CAS  Google Scholar 

  183. A. Kumar, V. Bansal, J. Andesson, P. K. Roychoudhury, B. Mattiasson, J. Chromatogr. A, 2006, 1103, 35.

    CAS  Google Scholar 

  184. M. B. Dainiak, A. Kumar, I. Yu. Galaev, B. Mattiasson, Proc. Nat. Acad. Sci. USA, 2006, 103, 849.

    CAS  Google Scholar 

  185. I. Yu. Galaev, M. B. Dainiak, F. M. Plieva, B. Mattiasson, Langmuir, 2007, 23, 35.

    CAS  Google Scholar 

  186. D. Ceylan, O. Okay, Macromolecules, 2007, 40, 8742.

    CAS  Google Scholar 

  187. W. Wang, Y. Gu, Y. Tabata, M. Miyamoto, H. Hori, N. Nagata, M. Touma, A. N. Balamurugan, Y. Kawakami, M. Nozawa, K. Inoue, Transplantation, 2002, 73, 122.

    Google Scholar 

  188. S. Stokols, M. H. Tuszynski, Biomaterials, 2006, 27, 443.

    CAS  Google Scholar 

  189. P. B. Malafaya, G. A. Silva, R. L. Reis, Adv. Drug Delivery Rev., 2007, 59, 207.

    CAS  Google Scholar 

  190. K. Bloch, V. I. Lozinsky, I. Yu. Galaev, K. Yavriyanz, M. Vorobeychik, D. Azarov, L. G. Damshkaln, B. Mattiasson, P. Vardi, J. Biomed. Mater. Res. A, 2005, 75, 802.

    CAS  Google Scholar 

  191. Yu. A. Petrenko, A. Yu. Petrenko, V. I. Lozinsky, I. V. Gurin, N. A. Gorokhova, N. A. Volkova, B. P. Sandomirskii, Transplantologiya (Kiïv) [Transplantology (Kiev)], 2007, 9, 221 (in Russian).

    Google Scholar 

  192. A. Yu. Petrenko, Yu. A. Petrenko, A. I. Pravduk, N. A. Gorokhova, V. I. Lozinsky, L. G. Damshkaln, I. G. Gurin, Yu. V. Malutin, I. A. Borovoy, N. G. Skorobogatova, N. A. Volkova, S. R. Mazur, Abstr. 2nd Ukrainian Congress for Cell Biology (Kiev, October 23–26, 2007), Kiev, 2007, 213.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to V. I. Lozinsky.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 996–1013, May, 2008.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lozinsky, V.I. Polymeric cryogels as a new family of macroporous and supermacroporous materials for biotechnological purposes. Russ Chem Bull 57, 1015–1032 (2008). https://doi.org/10.1007/s11172-008-0131-7

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11172-008-0131-7

Key words

Navigation