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The feasibility and responsiveness of the health utilities index in patients with early-stage breast cancer: A prospective longitudinal study

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Abstract

Background

The health utilities index (HUI3) is a health measurement instrument based on individuals’ preferences for different health states. Breast cancer (BC) is common, with a high proportion of long-term survivors, making evaluation of treatment effects important. Feasibility and responsiveness of HUI3 was compared to the short-form 36 (SF-36) in patients with BC.

Methods

HUI3 and SF-36 were administered eight times: at initial surgical consultation, 1 week before surgery; 1 week, 3, 6, 12, 18, and 24 months after surgery. Effect size, analysis of variance, and Pearson product moment correlations were calculated. BC data were compared to normative values.

Results

Eighty-five patients were enrolled. Ninety-one percent of planned assessments were completed. HUI3 showed significant responsiveness (P < 0.01) after surgery and during recovery. HUI3 scores correlated with SF-36 scores. Comparison to normative data demonstrated the significant detrimental effect of BC diagnosis. Results showed long-term effects of treatment on physical health and positive effects on mental/emotional health in BC survivors.

Conclusion(s)

HUI3 was found to be feasible and responsive in our cohort of BC patients. Changes in HUI3 values over time, and compared to normative data, paralleled SF-36 scores. HUI3 is a valuable tool in health-related quality of life and cost-utility studies in patients with BC.

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Abbreviations

BC:

Breast cancer

HUI3:

Health utilities index

SF-36:

Short form 36

HRQL:

Health-related quality of life

QOL:

Quality of life

ANOVA:

Analysis of variance

QALYs:

Quality-adjusted life years

BCS:

Breast-conserving surgery

MRM:

Modified radical mastectomy

PET:

Positron emission tomography

IC:

Initial consult

MCS:

Mental component score

PCS:

Physical component score

PF:

Physical functioning

RP:

Role-physical

BP:

Bodily pain

RE:

Role-emotional

MH:

Mental health

GH:

General health

VT:

Vitality

SF:

Social functioning

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Acknowledgements

Funding for this study was provided by the Canadian Breast Cancer Research Initiative IDEA, Father Sean O’Sullivan Research Centre, and the Department of Surgery, McMaster University. The authors would like to thank Sheila Sprague, Luann Wu, Nycholle Charpentier, Dana Wood, and Alycia Fridkin for assistance with data management. Conflicts of interest: Dr. Goldsmith was a collaborator on several research grants for the development of the HUI and has received payment from HUI Inc. for consulting fees for statistical analyses.

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Authors and Affiliations

  1. Department of Surgery, Hamilton Health Sciences and St. Joseph’s Healthcare, McMaster University, Hamilton, ON, Canada, L8N 4A6

    Peter J. Lovrics, Sylvie D. Cornacchi & Francesco Barnabi

  2. Surgical Outcomes Research Centre, McMaster University, Hamilton, ON, Canada

    Peter J. Lovrics, Sylvie D. Cornacchi & Charles H. Goldsmith

  3. Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada

    Tim Whelan & Charles H. Goldsmith

  4. Department of Medicine and Supportive Cancer Care Research Unit, Juravinski Cancer Centre, McMaster University, Hamilton, ON, Canada

    Tim Whelan

  5. St. Joseph’s Healthcare, Biostatistics Unit, Father Sean O’Sullivan Research Centre, Hamilton, ON, Canada

    Charles H. Goldsmith

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  1. Peter J. Lovrics
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Correspondence to Peter J. Lovrics.

Appendix

Appendix

Appendix A Compliance with QOL assessments and pattern of missing data
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Lovrics, P.J., Cornacchi, S.D., Barnabi, F. et al. The feasibility and responsiveness of the health utilities index in patients with early-stage breast cancer: A prospective longitudinal study. Qual Life Res 17, 333–345 (2008). https://doi.org/10.1007/s11136-007-9305-2

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  • DOI: https://doi.org/10.1007/s11136-007-9305-2

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