Abstract
Nymphaea hybrid, a water lily from the Nymphaeaceae family, has been found to exhibit some in vivo beneficial effects. In the present study we investigated the lifespan-extending effects of Nymphaea hybrid root extract in the nematode Caenorhabditis elegans. We found that Nymphaea hybrid root extract significantly extended the lifespan of C.elegans and improved its locomotion during aging. Moreover, Nymphaea hybrid root extract increased the resistance of C.elegans to both heat stress and oxidative stress. We found that the ability of Nymphaea hybrid root extract to increase lifespan was independent of its antimicrobial effects and was probably associated with its effects on the reproduction of C.elegans. In addition, the lifespan-extending effects of Nymphaea hybrid root extract were found to be dependent on the insulin/IGF signaling pathway. We also found that total flavones of Nymphaea hybrid could increase survival of C.elegans in both normal and adverse conditions, indicating that total flavones comprise the major fractions with lifespan-extending effects. Therefore, Nymphaea hybrid root extract has lifespan-extending effects in C.elegans and could be developed as a functional food.
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Abbreviations
- NHRE:
-
Nymphaea hybrid root extract
- C. elegans :
-
Caenorhabditis elegans
- TFNH:
-
total flavones of Nymphaea hybrid
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Acknowledgments
This work was supported by National Natural Science Foundation of China (31300707), Scientific Starting Fund from Changzhou University (ZMF11020011), National Science and Technology Support Program (2011BAD33B03).
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Authors declare that they have no conflict of interest.
Human or Animal Studies
This article contain studies with Caenorhabditis elegans,which is a popular model animal.
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Ziheng Zhuang, Ting Lv and Min Li are contributed equally to this work.
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Zhuang, Z., Lv, T., Li, M. et al. The Lifespan-Extending Effects of Nymphaea hybrid Root Extract in the Nematode Caenorhabditis elegans . Plant Foods Hum Nutr 69, 304–309 (2014). https://doi.org/10.1007/s11130-014-0448-3
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DOI: https://doi.org/10.1007/s11130-014-0448-3