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Hypolipidemic and Antioxidative Effects of Noni (Morinda citrifolia L.) Juice on High- fat/Cholesterol-Dietary Hamsters

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Abstract

Noni juice (NJ) is rich in phytochemicals and polysaccharides. Lipid-lowering and antioxidative effects of NJ were investigated in this study. Fifty male hamsters were assigned randomly to one of the following groups: (1) normal diet and distilled water (LFCD); (2) high-fat/cholesterol diet and distilled water (HFCD); (3) HFCD and 3 ml NJ (including 0.20 g solids)/kg BW (NJ_L); (4) HFCD and 6 mL NJ (including 0.40 g solids)/kg BW (NJ_M); (5) HFCD and 9 ml NJ (including 0.60 g solids)/kg BW (NJ_H) for six weeks. NJ supplementation decreased (p < 0.05) serum triacylglycerol, cholesterol, atherogenic index, malondialdehyde levels, and hepatic lipids in HFCD hamsters, whereas serum trolox equivalent antioxidant capacity, glutathione, and fecal lipids in HFCD hamsters were increased (p < 0.05) by NJ supplementation. Although NJ supplementation downregulated (p < 0.05) sterol regulator element binding protein-1c in HFCD hamsters, it upregulated (p < 0.05) hepatic peroxisome proliferator-activated receptor-alpha and uncoupling protein 2 gene expressions in HFCD hamsters. Results demonstrate that NJ promotes cardioprotection in a high-fat/cholesterol diet.

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Acknowledgments

We would like to acknowledge the funding of this research from National Science Council, Taiwan (R.O.C.) (project number: NSC 98-2320-B-040-005-MY3) and Council of Agriculture, Executive Yuan, Taiwan (R.O.C.) (project number: 101AS -3.1.4-AD-U1(2)).

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Correspondence to Bor-Show Tzang or Yi-Chen Chen.

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B. S Tzang and Y. C. Chen contributed equally as corresponding authors.

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Lin, YL., Chou, CH., Yang, DJ. et al. Hypolipidemic and Antioxidative Effects of Noni (Morinda citrifolia L.) Juice on High- fat/Cholesterol-Dietary Hamsters. Plant Foods Hum Nutr 67, 294–302 (2012). https://doi.org/10.1007/s11130-012-0309-x

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  • DOI: https://doi.org/10.1007/s11130-012-0309-x

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