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Synthesis of Indolylaminophosphonic Acids as Promising Biologically Active Compounds with Wide Spectra of Pharmacological Action

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Pharmaceutical Chemistry Journal Aims and scope

A synthetic method for 2-amino-1-(1-indol-3-yl)ethylphosphonic acid and 2-amino-1-(1-methylindol-3-yl)ethylphosphonic acid hydrochlorides, i.e., new indole-containing functionalized aminophosphonic acids, is proposed. The reactions are carried out at room temperature in LiOH solution followed by precipitation of the salts using HCl. The synthesized indolylaminoethylphosphonic acids, the molecules of which contain an indole ring and amine and phosphonic groups, could be considered synthetic precursors of functionalized tryptamine analogs.

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The author declares no conflict of interest.

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Authors and Affiliations

  1. St. Petersburg State Pediatric Medical University, 2 Litovskaya St., St. Petersburg, 194100, Russia

    Z. M. Sarkisyan

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  1. Z. M. Sarkisyan
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Correspondence to Z. M. Sarkisyan.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 8, pp. 63 – 64, August, 2022.

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Sarkisyan, Z.M. Synthesis of Indolylaminophosphonic Acids as Promising Biologically Active Compounds with Wide Spectra of Pharmacological Action. Pharm Chem J 56, 1157–1158 (2022). https://doi.org/10.1007/s11094-022-02767-z

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