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Bioavailability of the Tablet Dosage Form of a Benzimidazole Derivative Possessing Antiplatelet Activity

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Pharmaceutical Chemistry Journal Aims and scope

The bioavailability of the tablet dosage form of pharmaceutical substance RU-891, i.e., 9-(3,4-dihydroxyphenacyl)-2,3-dihydroimidazo[1,2-a]benzimidazole hydrobromide, was investigated. The main pharmacokinetic parameters were determined. The relative bioavailability index was estimated at 93.98%. No evidence of drug accumulation from an RU-891 270-mg tablet dosage form was detected in rabbits upon threefold administration at a dose of 23 mg/kg.

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References

  1. Guideline on Bioanalytical Method Validation (EMEA 2012); http://www.ema.europa.eu.

  2. A. A. Spasov, V. A. Anisimova, et al., RU Pat. No. 2,453,312 C1, Jun. 20, 2012; Byull., No. 17 (2010).

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Authors and Affiliations

  1. Volgograd State Medical University, 1 Pavshikh Bortsov Sq., Volgograd, 400131, Russia

    A. A. Spasov, A. F. Kucheryavenko, K. A. Gaidukova, V. S. Sirotenko, L. A. Smirnova, A. F. Ryabukha, K. A. Kuznetsov & M. V. Velikopol’skaya

  2. Volgograd Medical Scientific Center, 1 Pavshikh Bortsov Sq., Volgograd, 400131, Russia

    A. A. Spasov, L. A. Smirnova, A. F. Ryabukha, K. A. Kuznetsov & M. V. Velikopol’skaya

Authors
  1. A. A. Spasov
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  2. A. F. Kucheryavenko
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  3. K. A. Gaidukova
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  4. V. S. Sirotenko
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  5. L. A. Smirnova
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  6. A. F. Ryabukha
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  7. K. A. Kuznetsov
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  8. M. V. Velikopol’skaya
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Corresponding author

Correspondence to A. F. Ryabukha.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 8, pp. 8 – 10, August, 2022.

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Spasov, A.A., Kucheryavenko, A.F., Gaidukova, K.A. et al. Bioavailability of the Tablet Dosage Form of a Benzimidazole Derivative Possessing Antiplatelet Activity. Pharm Chem J 56, 1024–1026 (2022). https://doi.org/10.1007/s11094-022-02746-4

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  • DOI: https://doi.org/10.1007/s11094-022-02746-4

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