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Synthesis and Cytotoxicity Against Human Breast Carcinoma Cell Evaluation of Some New 3,4-Disubstituted Coumarin Derivatives

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Pharmaceutical Chemistry Journal Aims and scope

A novel series of 3,4-disubstitutued coumarin derivatives have been synthesized by the reaction of ethyl coumarin-3-carboxylate with pyrazole-3,5-dione and condensation of ethyl 7-hydroxycoumarin-3-carboxylate with 4,6-dibromo-3-amino phenol. Acylation with acetic anhydride and condensation of coumarin derivatives with 2-hydroxybenzaldehyde yielded the corresponding acetyl derivatives and 4-substituted pyrazole derivatives. Structures of the synthesized compounds were elucidated by spectral methods and elemental analysis. All the prepared derivatives were evaluated for their cytotoxicity against human breast carcinoma cell line (MCF-7). Compound VI showed the least IC50 value in MTT colorimetric assay as compared to that of the standard marketed drug staurosporin.

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Acknowledgements

The authors are thankful to nuclear magnetic resonance lab in faculty of pharmacy, Mansoura University and nuclear magnetic resonance lab in Beni-suef University for using their laboratory equipments during this work.

COMPLIANCE WITH ETHICAL STANDARDS

This article does not contain any studies involving human participants or animals performed by any of the authors in this work.

CONFLICT OF INTERESTS

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Port-Said University, 23 December Street, Port-Said, 42521, Egypt

    Eman M. Radwan, Elsherbiny H. Elsayed, Mohamed Abd El-Moneim & Amal M. Youssef Moustafa

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  1. Eman M. Radwan
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  2. Elsherbiny H. Elsayed
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  3. Mohamed Abd El-Moneim
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  4. Amal M. Youssef Moustafa
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Radwan, E.M., Elsayed, E.H., El-Moneim, M.A. et al. Synthesis and Cytotoxicity Against Human Breast Carcinoma Cell Evaluation of Some New 3,4-Disubstituted Coumarin Derivatives. Pharm Chem J 55, 1040–1049 (2022). https://doi.org/10.1007/s11094-021-02535-5

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  • DOI: https://doi.org/10.1007/s11094-021-02535-5

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