2-Adamantylaminopropanol hydrochloride (ADK-971) and 5-hydroxyadamantan-2-ylaminopropanol hydrochloride (ADK-1013) were less active than hemantane in parkinsonian syndrome murine models. ADK-971 and AKD-1013, like hemantane at a dose of 20 mg/kg, exhibited comparable antiexudative effects in the mouse acetic peritonitis model. However, ADK-971 and ADK-1013 (20 mg/kg), in contrast to hemantane at the same dose, did not possess analgesic effects against visceral and thermal somatic pain in mice.
Similar content being viewed by others
References
https://www.rlsnet.ru/mnn index id 2206.htm#primenenie-veshhestva-memantin
A. V. Nepoklonov, I. G. Kapitsa, E. A. Ivanova, et al., Eksp. Klin. Farm., 75(11), 3 – 6 (2012).
E. A. Ivanova, A. V. Nepoklonov, I. I. Kokshenev, et al., Biomeditsina, 1(1), 74 – 81 (2012).
E. A. Ivanova, I. G. Kapitsa, E. A. Val’dman, and T. A. Voronina, Byull. Eksp. Biol. Med., 159(3), 362 – 365 (2015).
E. A. Katunina, A. V. Petrukhova, G. N. Avakyan, et al., Zh. Nevrol. Psikhiatr. im. S. S. Korsakova, 108(6), 24 – 27 (2008).
E. A. Ivanova, I. G. Kapitsa, A. V. Nepoklonov, et al., Khim.- farm. Zh., 47(10), 12 – 15 (2013); Pharm. Chem. J., 47(10), 517 – 520 (2013).
E. A. Ivanova, I. G. Kapitsa, E. A. Valdman, and T. A. Voronina, Adv. Parkinson’s Dis., No. 5, 50 – 60 (2016).
I. G. Kapitsa, E. A. Ivanova, T. A. Voronina, et al., Farmakokinet. Farmakodin., No. 3, 42 – 46 (2016).
RU Pat. Appl. 4,947,575 / 04; Byull. Izobret., No. 4 (2011).
N. I. Avdyunina, I. S. Morozov, et al., RU Pat. 1,746,661, Jan. 10, 1996.
N. V. Klimova, B. M. Pyatin, N. M. Zaitseva, et al., Khim.-farm. Zh., 20(7), 810 – 915 (1986).
T. A. Voronina, E. A Val’dman, L. N. Nerobkova, and I. G. Kapitsa, Methodical Recommendations for Preclinical Trials of Antiparkinsonian Drugs [in Russian], in: Handbook for Preclinical Drug Trials [in Russian], Part 1, Grif i K, Moscow, 2012, pp. 219 – 234.
J. L. Tillerson and G. W. Miller, J. Neurosci. Methods, 123(2), 189 – 200 (2003).
G. Ya. Shvarts and R. D. Syubaev, Methodical Recommendations for Preclinical Trials of Nonsteroidal Anti-Inflammatory Drugs [in Russian], in: Handbook for Preclinical Drug Trials [in Russian], Part 1, Grif i K, Moscow, 2012, pp. 746 – 758.
T. A. Voronina and L. S. Guzevatykh, Methodical Recommendations for Preclinical Trials of Analgesic Drugs [in Russian], in: Handbook for Preclinical Drug Trials [in Russian], Part 1, Grif i K, Moscow, 2012, pp. 197 – 218.
I. G. Kapitsa, I. I. Kokshenev, E. A. Val’dman, and T. A. Voronin, Farmakokinet. Farmakodin., No. 2, 10 – 16 (2012).
Acknowledgments
The work was sponsored by a State Task on Topic No. 0521-2019-0007.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 5, pp. 3 – 7, May, 2019.
Rights and permissions
About this article
Cite this article
Kapitsa, I.G., Ivanova, E.A., Avdyunina, N.I. et al. Comparative Evaluation of Antiparkinsonian, Anti-Inflammatory, and Analgesic Effects of Hemantane and Two 2-Aminoadamantane Derivatives Differing From it by a Bridgehead Hydroxyl. Pharm Chem J 53, 383–387 (2019). https://doi.org/10.1007/s11094-019-02009-9
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-019-02009-9