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Hippocampal Acetylation may Improve Prenatal-Stress-Induced Depression-Like Behavior of Male Offspring Rats Through Regulating AMPARs Expression

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Abstract

This study is to determine the role and mechanism of hippocampal acetylation in prenatal stress (PS) induced depression-like behavior of male offspring rats. PS-induced depression rat model was established. Sucrose preference and forced swim test were used to observe the behavior changes of male offspring rats. Hippocampal acetylation was induced by Trichostatin A injection. Quantitative real-time PCR and Western blot were used to determine the changes of AMPARs in acetylated hippocampus. The behavioral tests proved that AMPA was involved in the PS-induced depression-like behavior in offspring rats. Hippocampal acetylation significantly increased the preference to sucrose of PS-induced offspring rats and reduced the immobile time in forced swimming test, suggesting that acetylation could improve PS-induced depression-like behaviors. In addition, PS inhibited the expression levels of GluA1-3 subunits of AMPARs in the offspring hippocampus, while Hippocampal acetylation could reverse this effect by increasing GluA1-3 expression. PS-induced reduction of GluA1-3 subunits of AMPARs may be an important potential mechanism of offspring depression. Hippocampal acetylation may improve PS-induced offspring depression-like behavior through the enhanced expression of AMPARs (GluA1-3 subunits).

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Acknowledgements

This work was supported by National Natural Science Foundation of China (No. 81271497) and Medical and Health Technology Development Project of Shandong Province (No. 2015WS0452).

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Authors and Affiliations

  1. Department of Neonatology, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 West Yanta Road, Yanta District, Xi’an, 710061, Shanxi, China

    Yong Lu, Shaokang Dang, Qian Su, Huiping Zhang, Hongli Sun & Hui Li

  2. Center Laboratory, Heze Medical College, Heze, 274000, Shandong, China

    Yong Lu

  3. Shaanxi Province Biomedicine Key Laboratory, College of Life Sciences, Northwest University, No. 229 North Taibai North Road, Beilin District, Xi’an, 710069, Shanxi, China

    Junli Zhang, Lin Zhang, Tianwei Lin, Xiaoxiao Zhang & Zhongliang Zhu

  4. Department of Pharmacy, The First Affiliated Hospital of Xi’an Medical College, Xi’an, 710077, Shanxi, China

    Yurong Zhang

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  1. Yong Lu
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Correspondence to Hui Li.

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Lu, Y., Zhang, J., Zhang, L. et al. Hippocampal Acetylation may Improve Prenatal-Stress-Induced Depression-Like Behavior of Male Offspring Rats Through Regulating AMPARs Expression. Neurochem Res 42, 3456–3464 (2017). https://doi.org/10.1007/s11064-017-2393-7

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  • DOI: https://doi.org/10.1007/s11064-017-2393-7

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