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The diagnostic accuracy of multiparametric MRI to determine pediatric brain tumor grades and types

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Abstract

Childhood brain tumors show great histological variability. The goal of this retrospective study was to assess the diagnostic accuracy of multimodal MR imaging (diffusion, perfusion, MR spectroscopy) in the distinction of pediatric brain tumor grades and types. Seventy-six patients (range 1 month to 18 years) with brain tumors underwent multimodal MR imaging. Tumors were categorized by grade (I–IV) and by histological type (A–H). Multivariate statistical analysis was performed to evaluate the diagnostic accuracy of single and combined MR modalities, and of single imaging parameters to distinguish the different groups. The highest diagnostic accuracy for tumor grading was obtained with diffusion–perfusion (73.24 %) and for tumor typing with diffusion–perfusion–MR spectroscopy (55.76 %). The best diagnostic accuracy was obtained for tumor grading in I and IV and for tumor typing in embryonal tumor and pilocytic astrocytoma. Poor accuracy was seen in other grades and types. ADC and rADC were the best parameters for tumor grading and typing followed by choline level with an intermediate echo time, CBV for grading and Tmax for typing. Multiparametric MR imaging can be accurate in determining tumor grades (primarily grades I and IV) and types (mainly pilocytic astrocytomas and embryonal tumors) in children.

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Authors and Affiliations

  1. Service de Radiopédiatrie/Imagerie 2, CHU de Strasbourg-Hôpital de Hautepierre, 1 Avenue Molière, 67098, Strasbourg Cedex, France

    Mériam Koob

  2. Laboratoire ICube, UMR 7357/FMTS/Université de Strasbourg-CNRS, Strasbourg Cedex, France

    Mériam Koob

  3. Service de Neuroradiologie Diagnostique et Interventionnelle, APHM Timone, 264, rue Saint Pierre, 13385, Marseille Cedex, France

    Nadine Girard

  4. Aix*Marseille Université, CRMBM, UMR CNRS 7339, 13385, Marseille Cedex, France

    Nadine Girard & Sylviane Confort-Gouny

  5. Département de Mathématiques, Faculté des Sciences de Luminy, 13385, Marseille, France

    Badih Ghattas

  6. Department of Radiological Sciences, St. Jude Children’s Research Hospital, Memphis, USA

    Slim Fellah

  7. Service d’Anatomie Pathologique et de Neuropathologie, APHM Timone, 264, rue Saint Pierre, 13385, Marseille Cedex 5, France

    Dominique Figarella-Branger

  8. Aix*Marseille Université, Inserm, CR02 UMR -S911, 13385, Marseille, France

    Dominique Figarella-Branger

  9. Service de Neurochirurgie Pédiatrique, APHM Timone, 264, rue Saint Pierre, 13385, Marseille Cedex 5, France

    Didier Scavarda

Authors
  1. Mériam Koob
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  2. Nadine Girard
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  3. Badih Ghattas
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  4. Slim Fellah
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  5. Sylviane Confort-Gouny
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  6. Dominique Figarella-Branger
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Corresponding author

Correspondence to Mériam Koob.

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Conflict of interest

N Girard has consulting with Olea Medical.

Electronic supplementary material

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11060_2015_2042_MOESM1_ESM.tif

Example of ROI placement in a posterior fossa medulloblastoma. The ROI positioned on the CBV map over the solid part of the tumor and the control ROI in left cerebellar grey matter are automatically overlaid on the other perfusion (corrected CBV, K2, MTT, TTP, tMIP) and ADC maps, as well as on T2WI and post-GBCAs T1WI. This prevents the inclusion of macroscopic vessels within the ROI. The perfusion curve is at the top left. Supplementary material 1 (TIFF 5605 kb)

11060_2015_2042_MOESM2_ESM.tif

Diagnostic accuracy (%) as a function of the number of best-performing parameters successively added for the determination of tumour grading. Supplementary material 2 (TIFF 892 kb)

11060_2015_2042_MOESM3_ESM.tif

Diagnostic accuracy (%) as a function of the number of best-performing parameters successively added for the determination of typing. Supplementary material 3 (TIFF 892 kb)

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Koob, M., Girard, N., Ghattas, B. et al. The diagnostic accuracy of multiparametric MRI to determine pediatric brain tumor grades and types. J Neurooncol 127, 345–353 (2016). https://doi.org/10.1007/s11060-015-2042-4

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  • DOI: https://doi.org/10.1007/s11060-015-2042-4

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