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The role of emerging therapy in the management of patients with diffuse low grade glioma

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Abstract

Question

What is the role of immunotherapy/tumor vaccines in the treatment of low grade gliomas?

Target population

Adult patients with newly diagnosed WHO grade 2 astrocytoma, oligo-astroctyoma, or oligodendroglioma.

Recommendations

There is no evidence to support a recommendation in regards to the efficacy of immunotherapy or tumor vaccines for the treatment of low grade gliomas. It is recommended that patients be enrolled in properly designed clinical trials to assess immunotherapies and tumor vaccines for low grade gliomas.

Question

What is the role of nutrition in the treatment of low grade gliomas?

Target population

Adult patients with newly diagnosed WHO grade 2 astrocytoma, oligo-astroctyoma, or oligodendroglioma.

Recommendations

There was no evidence to support a recommendation in regard to the efficacy of nutritional therapy for the treatment of low grade gliomas. It is recommended that patients be enrolled in properly designed clinical trials to assess the efficacy of nutrition for this target population.

Question

Is there a role for alternative or targeted therapies in the treatment of low grade gliomas?

Target population

Adult patients with newly diagnosed WHO grade 2 astrocytoma, oligo-astroctyoma, or oligodendroglioma.

Recommendation

There was no evidence to support a recommendation in regard to the efficacy of targeted or alternative agents for the treatment of low grade gliomas. It is recommended that patients be enrolled in properly designed clinical trials to assess alternative and targeted therapies for this target population.

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References

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Acknowledgments

We acknowledge the significant contributions of Laura Mitchell, Senior Manager of Guidelines for the CNS, and also the AANS/CNS Joint Guidelines Committee (JGC) for their review, comments and suggestions, as well as Anne Woznica, and Mary Bodach for their assistance with the literature searches. We would also like to acknowledge the following individual JGC members for their contributions throughout the review process: Kevin Cockroft, MD, Sepideh Amin-Hanjani, MD, KimonBekelis, MD, Isabelle Germano, MD, Daniel Hoh, MD, Steven Hwang, MD, CheeragDipakkumarUpadhyaya, MD, Christopher Winfree, MD, and Brad Zacharia, MD.

Disclosures

Dr. Kalkanis is a consultant for Arbor and Varian. Dr. Olson is a consultant for the American Cancer Society; has received research funding from the National Cancer Institute, Genentech, and Millenium; and has received investigational drug provision from Merck.

Author information

Authors and Affiliations

  1. Department of Neurosurgery and Seidman Cancer Center, University Hospitals and Case Comprehensive Cancer Center, 11100 Euclid Avenue, Cleveland, OH, USA

    Andrew E. Sloan

  2. University of Pittsburgh, Pittsburgh, PA, USA

    Hideho Okada

  3. Department of Neurosurgery, Kansas University Medical Center, Kansas City, KS, USA

    Timothy C. Ryken

  4. Department of Neurosurgery, Henry Ford Health System, Detroit, MI, USA

    Steven N. Kalkanis

  5. Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA

    Jeffrey J. Olson

Authors
  1. Andrew E. Sloan
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  2. Hideho Okada
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  3. Timothy C. Ryken
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  4. Steven N. Kalkanis
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  5. Jeffrey J. Olson
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Corresponding author

Correspondence to Andrew E. Sloan.

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Sloan, A.E., Okada, H., Ryken, T.C. et al. The role of emerging therapy in the management of patients with diffuse low grade glioma. J Neurooncol 125, 631–635 (2015). https://doi.org/10.1007/s11060-015-1865-3

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  • DOI: https://doi.org/10.1007/s11060-015-1865-3

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