Skip to main content

Advertisement

SpringerLink
Log in

Nebulized Liposomal Amphotericin B for Treatment of Pulmonary Infection Caused by Hormographiella aspergillata: Case Report and Literature Review

  • Published:
Mycopathologia Aims and scope Submit manuscript

Abstract

Invasive fungal infection is a serious complication following allogeneic hematopoietic stem cell transplantation. Pulmonary infection due to Hormographiella aspergillata is an uncommon condition associated with a high mortality rate. The susceptibility of H. aspergillata to available antifungal agents is not well established. We report for the first time a case of H. aspergillata lung infection that responded poorly to conventional treatment with liposomal amphotericin B (LAmB; 3 mg kg−1 of body weight per day) with renal damage at higher posology (5 mg kg−1 of body weight per day), but improved rapidly after addition of nebulized LAmB to intravenous LAmB (3 mg kg−1 of body weight per day). Successful treatment of our patient using nebulized LAmB would be worth evaluating in cases refractory to standard treatment or when the reference treatment may not be extended due to interaction or side effects.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Kontoyiannis DP, Marr KA, Park BJ, Alexander BD, Anaissie EJ, Walsh TJ, Ito J, Andes DR, Baddley JW, Brown JM, Brumble LM, Freifeld AG, Hadley S, Herwaldt LA, Kauffman CA, Knapp K, Lyon GM, Morrison VA, Papanicolaou G, Patterson TF, Perl TM, Schuster MG, Walker R, Wannemuehler KA, Wingard JR, Chiller TM, Pappas PG. Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001–2006: overview of the transplant-associated infection surveillance network (TRANSNET) database. Clin Infect Dis. 2010;50:1091–100.

    Article  PubMed  Google Scholar 

  2. Horn DL, Neofytos D, Anaissie EJ, Fishman JA, Steinbach WJ, Olyaei AJ, Marr KA, Pfaller MA, Chang CH, Webster K. Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry. Clin Infect Dis. 2009;48:1695–703.

    Article  CAS  PubMed  Google Scholar 

  3. Nanno S, Nakane T, Okamura H, Nishimoto M, Koh H, Nakamae H, Ohsawa M, Yarita K, Kamei K, Hino M. Disseminated Hormographiella aspergillata infection with involvement of the lung, brain, and small intestine following allogeneic hematopoietic stem cell transplantation: case report and literature review. Transpl Infect Dis. 2016;18:611–6.

    Article  CAS  PubMed  Google Scholar 

  4. Arendrup MC, Boekhout T, Akova M, Meis JF, Cornely OA, Lortholary O, European Society of Clinical Microbiology and Infectious Diseases Fungal Infection Study Group; European Confederation of Medical Mycology. ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections. Clin Microbiol Infect. 2014;20:76–98.

    Article  CAS  PubMed  Google Scholar 

  5. Hasseine L, Cassaing S, Robet-Gangneux F, Fillaux J, Marty P, Gangneux JP, The PF-qPCR Study Group. High predictive value diagnostic strategies for the reevaluation of early antifungal treatment: a multicenter prospective trial in patients at risk for invasive fungal infections. J Infect. 2015;7:258–65.

    Article  Google Scholar 

  6. Chowdhary A, Kathuria S, Agarwal K, Meis JF. Recognizing filamentous basidiomycetes as agents of human disease: a review. Med Mycol. 2014;52:782–97.

    Article  PubMed  Google Scholar 

  7. Verweij PE, van Kasteren M, van de Nes J, de Hoog GS, de Pauw BE, Meis JF. Fatal pulmonary infection caused by the basidiomycete Hormographiella aspergillata. J Clin Microbiol. 1997;35:2675–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Surmont I, Van Aelst F, Verbanck J, De Hoog GS. A pulmonary infection caused by Coprinus cinereus (Hormographiella aspergillata) diagnosed after a neutropenic episode. Med Mycol. 2002;40:217–9.

    Article  CAS  PubMed  Google Scholar 

  9. Lagrou K, Massonet C, Theunissen K, Meersseman W, Lontie M, Verbeken E, Van Eldere J, Maertens J. Fatal pulmonary infection in a leukaemic patient caused by Hormographiella aspergillata. J Med Microbiol. 2005;54:685–8.

    Article  PubMed  Google Scholar 

  10. Abuali MM, Posada R, Del Toro G, Roman E, Ramani R, Chaturvedi S, Chaturvedi V, LaBombardi VJ. Rhizomucor variabilis var. regularior and Hormographiella aspergillata infections in a leukemic bone marrow transplant recipient with refractory neutropenia. J Clin Microbiol. 2010;48:1018.

    Article  PubMed Central  Google Scholar 

  11. Suarez F, Olivier G, Garcia-Hermoso D, Randriamalala E, Ghez D, Bruneau J, Kauffmann-Lacroix C, Bougnoux ME, Lortholary O. Breakthrough Hormographiella aspergillata infections arising in neutropenic patients treated empirically with caspofungin. J Clin Microbiol. 2011;49:461–5.

    Article  PubMed  Google Scholar 

  12. Conen A, Weisser M, Hohler D, Frei R, Stern M. Hormographiella aspergillata: an emerging mould in acute leukaemia patients? Clin Microbiol Infect. 2011;17:273–7.

    Article  CAS  PubMed  Google Scholar 

  13. Pang KA, Godet C, Fekkar A, Scholler J, Nivoix Y, Letscher-Bru V, Massias L, Kauffmann-Lacroix C, Elsendoorn A, Uzunov M, Datry A, Herbrecht R. Breakthrough invasive mould infections in patients treated with caspofungin. J Infect. 2012;64:424–9.

    Article  PubMed  Google Scholar 

  14. Bojic M, Willinger B, Rath T, Tobudic S, Thalhammer F, Böhm A, Mitterbauer M, Schulenburg A, Wöhrer S, Kalhs P, Rabitsch W. Fatal skin and pulmonary infection caused by Hormographiella aspergillata in a leukaemic patient: case report and literature overview. Mycoses. 2013;56:687–9.

    Article  PubMed  Google Scholar 

  15. Heiblig M, Bozzoli V, Saison J, Thomas X, De Croze D, Traverse-Glehen A, Cosmidis A, Chidiac C, Ferry T, Alanio A, Bienvenu AL, Dupont D, Ducastelle-Lepretre S, Michallet M, Ader F, HEMINF Study group. Combined medico-surgical strategy for invasive sino-orbito-cerebral breakthrough fungal infection with Hormographiella aspergillata in an acute leukaemia patient. Mycoses. 2015;58:308–12.

    Article  CAS  PubMed  Google Scholar 

  16. Godet C, Goudet V, Laurent F, Le Moal G, Gounant V, Frat JP, Cateau E, Roblot F, Cadranel J. Nebulised liposomal amphotericin B for Aspergillus lung diseases: case series and literature review. Mycoses. 2015;58:173–80.

    Article  PubMed  Google Scholar 

  17. Scott LJ, Simpson D. Voriconazole: a review of its use in the management of invasive fungal infections. Drugs. 2007;67:269–98.

    Article  CAS  PubMed  Google Scholar 

  18. Cornillet A, Camus C, Nimubona S, Gandemer V, Tattevin P, Belleguic C, Chevrier S, Meunier C, Lebert C, Aupée M, Caulet-Maugendre S, Faucheux M, Lelong B, Leray E, Guiguen C, Gangneux JP. Comparison of epidemiological, clinical, and biological features of invasive aspergillosis in neutropenic and nonneutropenic patients: a 6-year survey. Clin Infect Dis. 2006;43:577–84.

    Article  CAS  PubMed  Google Scholar 

  19. Patterson TF, Thompson GR III, Denning DW, Fishman JA, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH, Steinbach WJ, Stevens DA, Walsh TJ, Wingard JR, Young JA, Bennett JE. Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;63:e1–60.

    Article  PubMed  Google Scholar 

  20. Birsan T, Taghavi S, Klepetko W. Treatment of Aspergillus-related ulcerative tracheobronchitis in lung transplant recipients. J Heart Lung Transplant. 1998;17:437–8.

    CAS  PubMed  Google Scholar 

  21. Dal Conte I, Riva G, Obert R, Lucchini A, Bechis G, De Rosa G, Gioannini P. Tracheobronchial aspergillosis in a patient with AIDS treated with aerosolized amphotericin B combined with itraconazole. Mycoses. 1996;39:371–4.

    Article  Google Scholar 

  22. Hanada S, Uruga H, Takaya H, Miyamoto A, Morokawa N, Kurosaki A, Kishi K. Nebulized liposomal amphotericin B for treating Aspergillus empyema with bronchopleural fistula. Am J Respir Crit Care Med. 2014;189:607–8.

    Article  PubMed  Google Scholar 

  23. Safdar A, O’Brien S, Kouri IF. Efficacy and feasibility of aerosolized amphotericin B lipid complex therapy in caspofungin breakthrough pulmonary zygomycosis. Bone Marrow Transplant. 2004;34:467–8.

    Article  CAS  PubMed  Google Scholar 

  24. Monforte V, López-Sánchez A, Zurbano F, Ussetti P, Solé A, Casals C, Cifrian J, de Pablos A, Bravo C, Román A. Prophylaxis with nebulized liposomal amphotericin B for Aspergillus infection in lung transplant patients does not cause changes in the lipid content of pulmonary surfactant. J Heart Lung Transplant. 2013;32:313–9.

    Article  PubMed  Google Scholar 

  25. Monforte V, Ussetti P, López R, Gavaldà J, Bravo C, de Pablo A, Pou L, Pahissa A, Morell F, Román A. Nebulized liposomal amphotericin B prophylaxis for Aspergillus infection in lung transplantation: pharmacokinetics and safety. J Heart Lung Transplant. 2009;28:170–5.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors wish to thank Jeffrey Arsham, an American medical translator working at the CHU of Poitiers, for reviewing and editing the original English-language manuscript.

Authors’ Contributions

CG was the guarantor for the entire manuscript; CG and JC participated in conception and design of the work; CG, EC, BR, MG, GLM, GB, JPM, XI, FR contributed to recruitment of patients (i.e., data collection); CG, EC, BR, MG, GLM, GB, JPM, XI, JC, FR participated in revising the manuscript for important intellectual content; all authors approved the final manuscript.

Author information

Authors and Affiliations

  1. Service de Maladies Infectieuses et Tropicales, CHU Poitiers, 86000, Poitiers, France

    Cendrine Godet, Blandine Rammaert, Marine Grosset, Gwenaël Le Moal, Guillaume Béraud, Jean Philippe Martellosio & France Roblot

  2. faculté de médecine et de Pharmacie, Université de Poitiers, 6 rue de la Milétrie, Poitiers, France

    Estelle Cateau, Blandine Rammaert & France Roblot

  3. Laboratoire de Parasitologie-Mycologie, CHU Poitiers, 86000, Poitiers, France

    Estelle Cateau & France Roblot

  4. Inserm U1070, 6 rue de la Milétrie, Poitiers, France

    Blandine Rammaert

  5. EA2694, Université Droit et Santé Lille 2, Lille, France

    Guillaume Béraud

  6. Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Hasselt, Belgium

    Guillaume Béraud

  7. Service de Parasitologie-Mycologie, CHU Toulouse, Toulouse, France

    Xavier Iriart

  8. Centre de Physiopathologie de Toulouse Purpan, INSERM UMR U1043, CNRS UMR 5282, Université de Toulouse, Toulouse, France

    Xavier Iriart

  9. Service de Pneumologie, AP-HP, Hôpital Tenon, Paris, France

    Jacques Cadranel

  10. Sorbonne Université, UPMC Université Paris 06, 75970, Paris, France

    Jacques Cadranel

  11. Service des Maladies Infectieuses et Tropicales, CHU de Poitiers, 86021, Poitiers Cedex, France

    Cendrine Godet

Authors
  1. Cendrine Godet
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Estelle Cateau
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Blandine Rammaert
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Marine Grosset
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Gwenaël Le Moal
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Guillaume Béraud
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jean Philippe Martellosio
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Xavier Iriart
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Jacques Cadranel
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. France Roblot
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Cendrine Godet.

Ethics declarations

Conflict of interest

Cendrine Godet received consultancy or speaker fees, travel support from Pfizer and MSD, Gilead, Basilea, Astellas, SOS Oxygene and ISIS Medical. Estelle Cateau received speaker fees and travel support from MSD, Pfizer and Astellas. Blandine Rammaert received travel grant for conference from MSD and Pfizer and speaker fees from MSD. Xavier Iriart received travel grants from Gilead and MSD. Marine Grosset, Gwenaël LE MOAL, Guillaume Béraud, Jean Philippe Martellosio, Jacques Cadranel and France Roblot have nothing to disclose.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Godet, C., Cateau, E., Rammaert, B. et al. Nebulized Liposomal Amphotericin B for Treatment of Pulmonary Infection Caused by Hormographiella aspergillata: Case Report and Literature Review. Mycopathologia 182, 709–713 (2017). https://doi.org/10.1007/s11046-017-0117-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11046-017-0117-9

Keywords

Search

Navigation