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Invasive Geotrichum clavatum Fungal Infection in an Acute Myeloid Leukaemia Patient: A Case Report and Review

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Abstract

Invasive Geotrichum clavatum fungal infections are extremely rare and unusual, occurring nearly exclusively in patients experiencing prolonged neutropenia during the treatment for acute myeloid leukaemia. Several groups of cases of fatal G. clavatum infection were reported in France between 2011 and 2012, but the ecological niche has not yet been identified. We report a case of a 32-year-old patient with acute myeloid leukaemia who developed G. clavatum sepsis with primary peritonitis, hepatic nodular lesions, and multivisceral failure during aplasia after induction followed by salvage chemotherapy. He was treated with voriconazole and is still alive 1 year after with controlled disease. We then discuss the epidemiological, clinical, and therapeutic features of these serious fungal infections compared to the published data.

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Authors and Affiliations

  1. Department of Hematology, Centre Henri Becquerel, rue d’Amiens, 76038, Rouen, France

    Vincent Camus, Aspasia Stamatoullas, Hélène Lanic, Fabrice Jardin, Pascal Lenain, Hervé Tilly & Stéphane Leprêtre

  2. Intensive Care Unit, Charles Nicolle University Hospital, Rouen, France

    Marie-Laure Thibault, Christophe Girault & Jean-Baptiste Michot

  3. Department of Biology, Centre Henri Becquerel, Rouen, France

    Marion David

  4. Department of Mycology-Parasitology, Charles Nicolle University Hospital, Rouen, France

    Gilles Gargala

  5. Department of Pharmacology, Charles Nicolle University Hospital, Rouen, France

    Patricia Compagnon & Fabien Lamoureux

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  1. Vincent Camus
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  2. Marie-Laure Thibault
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Correspondence to Stéphane Leprêtre.

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Camus, V., Thibault, ML., David, M. et al. Invasive Geotrichum clavatum Fungal Infection in an Acute Myeloid Leukaemia Patient: A Case Report and Review. Mycopathologia 177, 319–324 (2014). https://doi.org/10.1007/s11046-014-9746-4

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  • DOI: https://doi.org/10.1007/s11046-014-9746-4

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