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Vitex negundo and its medicinal value

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Abstract

Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. Vitex negundo (VN), commonly known as “chaste tree”, is an ethnobotanically important plant with enormous medicinal properties. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Several bioactive compounds have been extracted from leaves, seeds, roots in form of volatile oils, flavonoids, lignans, iridoids, terpenes, and steroids. These bioactive compounds exhibit anti-inflammatory, antioxidant, antidiabetic, anticancer, antimicrobial. VN is typically known for its role in the modulation of cellular events like apoptosis, cell cycle, motility of sperms, polycystic ovary disease, and menstrual cycle. VN, reportedly, perturbs many cancer-signaling pathways involving p-p38, p-ERK1/2, and p-JNK in LPS-elicited cells, N-terminal kinase (JNK), COX-1 pathways, MAPK, NF-κB, tumor necrosis factor α (TNF-α), Akt, mTOR, vascular endothelial growth factor, hypoxia-inducible factor (HIF-1α). Several bioactive compounds obtained from VN have been commercialized and others are under investigation. This is the first review presenting up-to-date information about the VN, its bioactive constituents and their mode of action.

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Acknowledgements

The authors are thankful to Central University of Punjab, India, for providing the necessary facilities to carry out this work.

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Authors and Affiliations

  1. Department of Biosciences, Central University of Punjab, Bathinda, India

    Balraj Singh Gill & Richa Mehra

  2. Department of Higher Education Himachal Pradesh, Shimla, Himachal Pradesh, India

    Balraj Singh Gill

  3. Department of Biotechnology, KMV College, Jalandhar, Punjab, India

    Navgeet

  4. Department of Plant Sciences, Central University of Punjab, Bathinda, India

    Sanjeev Kumar

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  1. Balraj Singh Gill
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Gill, B.S., Mehra, R., Navgeet et al. Vitex negundo and its medicinal value. Mol Biol Rep 45, 2925–2934 (2018). https://doi.org/10.1007/s11033-018-4421-3

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