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Has-miR-146a polymorphism (rs2910164) and cancer risk: a meta-analysis of 19 case–control studies

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Abstract

Epidemiological studies have evaluated the association between has-miR-146a polymorphism (rs2910164) and cancer risk. However, published data are still inconclusive. Here, we performed a meta-analysis to assess the relationship between has-miR-146a polymorphism (rs2910164) and cancer susceptibility until May 8, 2010. Nineteen published case–control studies including a total of 10,496 cases and 12,885 controls were acquired. Overall, Increased cancer risk was found in domain model (OR = 1.18, 95% CI: 1.03–1.35) rather than in other genetic models when all studies were pooled into the meta-analysis. Stratified analysis shown that significant association between rs2910164 polymorphism and cancer susceptibility was present in Asians (OR = 1.14, 95% CI: 1.01–1.29 for CG vs. CC; OR = 1.19, 95% CI: 1.03–1.39 for GG + CG vs. CC), but not in Caucasian populations. In the subgroup analysis by cancer types, no significantly increased risk of breast, gastric, prostate or bladder cancer were found in any of the genetic models. In summary, this meta-analysis suggests that has-miR-146a polymorphism (rs2910164) is associated with increased cancer susceptibility in Asians. However, further well-designed studies with large sample size will be necessary to validate the risk identified in the current meta-analysis.

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Acknowledgments

This study was supported by the National Nature Science Foundation of China (30901788) and Shandong Provincial Nature Science Foundation (ZR2010HQ038 and ZR2010HM059).

Conflict of interest

The authors have no financial or personal relationships to disclose that could inappropriately influence or bias this work.

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Authors and Affiliations

  1. Department of Oncology, General Hospital, Jinan Command of the People’s Liberation Army, Shifan Street 25, Tianqiao District, Jinan, 250031, China

    Jun Wang, Jingwang Bi, Xin Liu, Kainan Li, Jianshi Di & Baocheng Wang

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  1. Jun Wang
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  2. Jingwang Bi
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  3. Xin Liu
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  4. Kainan Li
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Correspondence to Baocheng Wang.

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Jun Wang and Jingwang Bi have equally contributed to this work.

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Wang, J., Bi, J., Liu, X. et al. Has-miR-146a polymorphism (rs2910164) and cancer risk: a meta-analysis of 19 case–control studies. Mol Biol Rep 39, 4571–4579 (2012). https://doi.org/10.1007/s11033-011-1247-7

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  • DOI: https://doi.org/10.1007/s11033-011-1247-7

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