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Polymer resin library and the discovery of highly efficient polymer supported reagents and scavengers

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Summary

This paper is focused on the preparation of a library of highly efficient, tailor made, macroporous resins as supports for reagents and scavengers. From this library a macroporous resin, prepared with 40% cross-linking and with a porogen level of 300% in toluene gave a material superior to those presently available, and was shown to be highly efficient in the preparation of novel highly reactive polymer supported reagents, including scavengers and oxidants.

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Abbreviations

BET:

Brunauer–Emmett–Teller nitrogen adsoption/desorption

BOC:

t-butyloxy carbonyl

BPO:

dibenzoyl peroxide

CMS:

4-chloromethylstyrene

DVB:

divinylbenzene

PASP:

polymer assisted solution phase synthesis

PDI:

1,4-phenylene diisocyanate

PEG:

polyethyleneglycol

PSP:

polymer supported perruthenate

SEM:

scanning electron microscopy

SPOS:

solid phase organic synthesis

SPPS:

solid phase peptide synthesis

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Authors and Affiliations

  1. Combinatorial Centre of Excellence, School of Chemistry, University of Southampton, Highfield, Southampton, SO 17 1BJ, UK

    Nicola Galaffu, Gianluca Sechi & Mark Bradley

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  1. Nicola Galaffu
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  2. Gianluca Sechi
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  3. Mark Bradley
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Correspondence to Mark Bradley.

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Galaffu, N., Sechi, G. & Bradley, M. Polymer resin library and the discovery of highly efficient polymer supported reagents and scavengers. Mol Divers 9, 263–275 (2005). https://doi.org/10.1007/s11030-005-7458-x

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  • DOI: https://doi.org/10.1007/s11030-005-7458-x

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