Abstract
Radiolabeled epidermal growth factor receptor (EGFR) targeted antibody could be used for imaging EGFR expressing cancer. In this study, the SPECT probe 125I-Necitumumab were synthesized and evaluated for SPECT imaging of non-small cell lung cancer (NSCLC). In vivo biodistribution study indicated that 125I-Necitumumab was cleared rapidly in most organs and tissues. Though the tumor expressed a relatively high level of EGFR, however SPECT images showed no obvious uptake in the tumors. Therefore, we considered that 125I-Necitumumab was not suitable for EGFR-targeted NSCLC SPECT imaging.
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This study was financially supported by grants from the National Nature Science Foundation of China (NSFC) under Contract No.11505269 and the Strategic Priority and Research Program of Chinese Academy of Science under Contract No. XDA02000000.
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Lu, X., Li, X., Peng, Y. et al. Radiolabeling and biological evaluation of 125I-Necitumumab for EGFR-targeted SPECT imaging. J Radioanal Nucl Chem 323, 83–89 (2020). https://doi.org/10.1007/s10967-019-06933-8
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DOI: https://doi.org/10.1007/s10967-019-06933-8