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Production of 177Lu by hafnium irradiation using 55-MeV bremsstrahlung photons

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Abstract

The possibility of production a medical radionuclide 177Lu by irradiating natHfO2 by bremsstrahlung photons up to 55 MeV was investigated. The yields of the main nuclear reactions were measured. A procedure for one-step separation of carrier free 177Lu via extraction chromatography on the LN resin sorbent (Triskem) was developed. The radiochemical yield was 98%, separation factor was higher than 105. Isomeric ratio 177mLu/177Lu was estimated. Simulation of 177Lu production in photonuclear reactions on 178Hf, 179Hf and natHf nuclei was performed. The possibility of production of medical quantities was discussed.

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Authors and Affiliations

  1. Department of Nuclear and Radiation Medicine, National Research Center ‘‘Kurchatov Institute’’, Akademika Kurchatova pl., 1, Moscow, Russia, 123182

    Andrey G. Kazakov & Ramiz A. Aliev

  2. Chemistry Department, Lomonosov Moscow State University, Leninskie Gory, 1, Moscow, Russia, 119991

    Andrey G. Kazakov, Taisya Yu. Ekatova & Ramiz A. Aliev

  3. Physics Department, Lomonosov Moscow State University, Leninskie Gory, 1, Moscow, Russia, 119991

    Sergey S. Belyshev & Alexander A. Kuznetsov

  4. Skobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Leninskie Gory, 1, Moscow, Russia, 119991

    Vadim V. Khankin & Alexander A. Kuznetsov

Authors
  1. Andrey G. Kazakov
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  2. Sergey S. Belyshev
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  3. Taisya Yu. Ekatova
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  4. Vadim V. Khankin
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  5. Alexander A. Kuznetsov
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  6. Ramiz A. Aliev
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Correspondence to Andrey G. Kazakov.

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Kazakov, A.G., Belyshev, S.S., Ekatova, T.Y. et al. Production of 177Lu by hafnium irradiation using 55-MeV bremsstrahlung photons. J Radioanal Nucl Chem 317, 1469–1476 (2018). https://doi.org/10.1007/s10967-018-6036-5

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  • DOI: https://doi.org/10.1007/s10967-018-6036-5

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