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Effect of collagen fibril formation on bioresorbability of hydroxyapatite/collagen composites

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Abstract

Porous hydroxyapatite/collagen (HAp/Col) composite is a promising biomaterial and a scaffold for bone tissue engineering. The effect of fibril formation of Col in the porous composite on bioresorbability and mechanical strength was investigated. The fibril formation, in mixing a self-organized HAp/Col nanocomposite and sodium phosphate buffer at a neutral condition, occurred during incubation at 37 °C, resulting in gelation of the mixture. The porous composites with and without the incubation were obtained by freeze-drying technique, in which macroscopic open pores were formed. The compressive strength of the porous composite with the incubation (34.1 ± 1.6 kPa) was significantly higher than that without the incubation (28.0 ± 3.3 kPa) due to the fibril formation of Col. The implantations of the porous composites treated with a dehydrothermal treatment in bone holes revealed that bioresorption was clearly depended on the fibril formation. The bioresorbability in vivo was almost matched to the in vitro test using enzymatic reaction of collagenase.

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Acknowledgements

This work is supported by Research Promotion Bureau, Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. Leading Project: Development of Artificial Organs utilizing with Nanotechnology and Materials Science, FY2005.

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Authors and Affiliations

  1. Biomaterial Center, National Institute for Materials Science, Namiki 1-1, Tsukuba, Ibaraki, 305-0044, Japan

    Shunji Yunoki, Toshiyuki Ikoma, Hongsong Fan, Xingdong Zhang & Junzo Tanaka

  2. Division of Frontier Research, Creative Research Initiative “SOUSEI” (CRIS), Hokkaido University, Kita 21, Nishi 10, Kita-ku, Sapporo, 001-0021, Japan

    Shunji Yunoki & Junzo Tanaka

  3. Department of Orthopaedic Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan

    Eriko Marukawa, Shinichi Sotome & Kenichi Shinomiya

  4. Engineering Research Center in Biomaterials, Sichuan University, Chengdu, 610064, P. R. China

    Hongsong Fan & Xingdong Zhang

Authors
  1. Shunji Yunoki
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  2. Eriko Marukawa
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  3. Toshiyuki Ikoma
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  4. Shinichi Sotome
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  5. Hongsong Fan
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  6. Xingdong Zhang
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  7. Kenichi Shinomiya
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  8. Junzo Tanaka
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Correspondence to Shunji Yunoki.

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Yunoki, S., Marukawa, E., Ikoma, T. et al. Effect of collagen fibril formation on bioresorbability of hydroxyapatite/collagen composites. J Mater Sci: Mater Med 18, 2179–2183 (2007). https://doi.org/10.1007/s10856-007-3011-z

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  • DOI: https://doi.org/10.1007/s10856-007-3011-z

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