Skip to main content
Log in

Point-by-point pulmonary vein antrum isolation guided by intracardiac echocardiography and 3D mapping and duty-cycled multipolar AF ablation: effect of multipolar ablation on procedure duration and fluoroscopy time

  • Published:
Journal of Interventional Cardiac Electrophysiology Aims and scope Submit manuscript

Abstract

Purpose

Pulmonary vein antrum isolation (PVAI) guided by intracardiac echocardiography and a roaming circular mapping catheter is an effective treatment modality for atrial fibrillation. Unfortunately, the complexity of this technique leads to long procedure times and high fluoroscopy exposure. Single-catheter multipolar ablation holds the promise to reduce these parameters. This study examined the effect of the conventional point-by-point PVAI with that of single-catheter multipolar ablation on the procedural characteristics and clinical outcomes of atrial fibrillation ablation.

Methods

Referred patients underwent PVAI guided by a magnetic-based 3D mapping (CARTO 3® System; group 1) or duty-cycled multipolar AF ablation using the pulmonary vein ablation catheter (PVAC, group 2) between June 2010 and May 2011.

Results

Data were analyzed from 19 patients in group 1 and 31 patients in group 2. There was no significant difference in the length of the procedure between the two groups (135 ± 26 vs 125 ± 25 min, P = 0.20). Patients who underwent ablation using PVAC spent significantly less time in the procedure room pre- and post-procedure than those who underwent conventional PVAI (205 ± 38 vs 179 ± 30 min, P = 0.02) and had a significantly shorter fluoroscopy exposure (50 ± 16 vs 36 ± 14 min, P = 0.003) and radiofrequency energy delivery time (54 ± 26 vs 32 ± 33 min, P = 0.02). No differences in safety and efficacy were seen between the groups.

Conclusions

Single-catheter multipolar AF ablation was associated with significantly lower fluoroscopy duration, radiofrequency energy delivery time, and the time the patient spent in the procedure room before and after ablation, although measured short-term clinical outcomes were similar.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Benjamin, E. J., Wolf, P. A., D’Agostino, R. B., Silbershatz, H., Kannel, W. B., & Levy, D. (1998). Impact of atrial fibrillation on the risk of death: the Framingham Heart Study. Circulation, 98(10), 946–952.

    Article  PubMed  CAS  Google Scholar 

  2. Wolf, P. A., Mitchell, J. B., Baker, C. S., Kannel, W. B., & D’Agostino, R. B. (1998). Impact of atrial fibrillation on mortality, stroke, and medical costs. Archives of Internal Medicine, 158(3), 229–234.

    Article  PubMed  CAS  Google Scholar 

  3. Fuster, V., Ryden, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., et al. (2006). ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation, 114(7), e257–e354.

    Article  PubMed  Google Scholar 

  4. Dorian, P., Jung, W., Newman, D., Paquette, M., Wood, K., Ayers, G. M., et al. (2000). The impairment of health-related quality of life in patients with intermittent atrial fibrillation: Implications for the assessment of investigational therapy. Journal of the American College of Cardiology, 36(4), 1303–1309.

    Article  PubMed  CAS  Google Scholar 

  5. Crandall, M. A., Bradley, D. J., Packer, D. L., & Asirvatham, S. J. (2009). Contemporary management of atrial fibrillation: Update on anticoagulation and invasive management strategies. Mayo Clinic proceedings. Mayo Clinic, 84(7), 643–662.

    Google Scholar 

  6. Chung, M. K., Shemanski, L., Sherman, D. G., Greene, H. L., Hogan, D. B., Kellen, J. C., et al. (2005). Functional status in rate- versus rhythm-control strategies for atrial fibrillation: Results of the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Functional Status Substudy. Journal of the American College of Cardiology, 46(10), 1891–1899.

    Article  PubMed  Google Scholar 

  7. Corley, S. D., Epstein, A. E., DiMarco, J. P., Domanski, M. J., Geller, N., Greene, H. L., et al. (2004). Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study. Circulation, 109(12), 1509–1513.

    Article  PubMed  Google Scholar 

  8. Guglin, M., Chen, R., & Curtis, A. B. (2010). Sinus rhythm is associated with fewer heart failure symptoms: Insights from the AFFIRM trial. Heart Rhythm, 7(5), 596–601.

    Article  PubMed  Google Scholar 

  9. Haissaguerre, M., Jais, P., Shah, D. C., Takahashi, A., Hocini, M., Quiniou, G., et al. (1998). Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. The New England Journal of Medicine, 339(10), 659–666.

    Article  PubMed  CAS  Google Scholar 

  10. Chen, S. A., Hsieh, M. H., Tai, C. T., Tsai, C. F., Prakash, V. S., Yu, W. C., et al. (1999). Initiation of atrial fibrillation by ectopic beats originating from the pulmonary veins: Electrophysiological characteristics, pharmacological responses, and effects of radiofrequency ablation. Circulation, 100(18), 1879–1886.

    Article  PubMed  CAS  Google Scholar 

  11. Haissaguerre, M., Shah, D. C., Jais, P., Hocini, M., Yamane, T., Deisenhofer, I., et al. (2000). Electrophysiological breakthroughs from the left atrium to the pulmonary veins. Circulation, 102(20), 2463–2465.

    Article  PubMed  CAS  Google Scholar 

  12. Natale, A., Pisano, E., Shewchik, J., Bash, D., Fanelli, R., Potenza, D., et al. (2000). First human experience with pulmonary vein isolation using a through-the-balloon circumferential ultrasound ablation system for recurrent atrial fibrillation. Circulation, 102(16), 1879–1882.

    Article  PubMed  CAS  Google Scholar 

  13. Pappone, C., Oreto, G., Lamberti, F., Vicedomini, G., Loricchio, M. L., Shpun, S., et al. (1999). Catheter ablation of paroxysmal atrial fibrillation using a 3D mapping system. Circulation, 100(11), 1203–1208.

    Article  PubMed  CAS  Google Scholar 

  14. Marrouche, N. F., Dresing, T., Cole, C., Bash, D., Saad, E., Balaban, K., et al. (2002). Circular mapping and ablation of the pulmonary veins for treatment of atrial fibrillation. Impact of different catheter technologies. J Am Coll Cardiol, 40(3), 464–474.

    Article  PubMed  Google Scholar 

  15. Khaykin Y, Oosthuizen R, Zarnett L, Essebag V, Parkash R, Seabrook C, et al., Clinical predictors of arrhythmia recurrences following pulmonary vein antrum isolation for atrial fibrillation: Predicting arrhythmia recurrence post-PVAI. Journal of cardiovascular electrophysiology, 2011.

  16. Hussein, A. A., Saliba, W. I., Martin, D. O., Bhargava, M., Sherman, M., Magnelli-Reyes, C., et al. (2011). Natural history and long-term outcomes of ablated atrial fibrillation. Circulation. Arrhythmia and Electrophysiology, 4(3), 271–278.

    Article  PubMed  Google Scholar 

  17. Estner, H. L., Deisenhofer, I., Luik, A., Ndrepepa, G., von Bary, C., Zrenner, B., et al. (2006). Electrical isolation of pulmonary veins in patients with atrial fibrillation: reduction of fluoroscopy exposure and procedure duration by the use of a non-fluoroscopic navigation system (NavX). Europace, 8(8), 583–587.

    Article  PubMed  Google Scholar 

  18. Lakkireddy, D., Nadzam, G., Verma, A., Prasad, S., Ryschon, K., Di Biase, L., et al. (2009). Impact of a comprehensive safety program on radiation exposure during catheter ablation of atrial fibrillation: A prospective study. Journal of Interventional Cardiac Electrophysiology, 24(2), 105–112.

    Article  PubMed  Google Scholar 

  19. Rotter, M., Takahashi, Y., Sanders, P., Haissaguerre, M., Jais, P., Hsu, L. F., et al. (2005). Reduction of fluoroscopy exposure and procedure duration during ablation of atrial fibrillation using a novel anatomical navigation system. European Heart Journal, 26(14), 1415–1421.

    Article  PubMed  Google Scholar 

  20. Khaykin, Y., Oosthuizen, R., Zarnett, L., Wulffhart, Z. A., Whaley, B., Hill, C., et al. (2011). CARTO-guided vs. NavX-guided pulmonary vein antrum isolation and pulmonary vein antrum isolation performed without 3-D mapping: effect of the 3-D mapping system on procedure duration and fluoroscopy time. Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing, 30(3), 233–240.

    Article  Google Scholar 

  21. Knackstedt, C., Schauerte, P., & Kirchhof, P. (2008). Electro-anatomic mapping systems in arrhythmias. Europace, 10(Suppl 3), iii28–34.

    Article  PubMed  Google Scholar 

  22. Piorkowski, C., Hindricks, G., Schreiber, D., Tanner, H., Weise, W., Koch, A., et al. (2006). Electroanatomic reconstruction of the left atrium, pulmonary veins, and esophagus compared with the “true anatomy” on multislice computed tomography in patients undergoing catheter ablation of atrial fibrillation. Heart Rhythm, 3(3), 317–327.

    Article  PubMed  Google Scholar 

  23. Boersma, L. V., Wijffels, M. C., Oral, H., Wever, E. F., & Morady, F. (2008). Pulmonary vein isolation by duty-cycled bipolar and unipolar radiofrequency energy with a multielectrode ablation catheter. Heart Rhythm, 5(12), 1635–1642.

    Article  PubMed  Google Scholar 

  24. Scharf, C., Boersma, L., Davies, W., Kanagaratnam, P., Peters, N. S., Paul, V., et al. (2009). Ablation of persistent atrial fibrillation using multielectrode catheters and duty-cycled radiofrequency energy. Journal of the American College of Cardiology, 54(15), 1450–1456.

    Article  PubMed  Google Scholar 

  25. Wieczorek, M., Hoeltgen, R., Akin, E., Salili, A. R., Oral, H., & Morady, F. (2010). Results of short-term and long-term pulmonary vein isolation for paroxysmal atrial fibrillation using duty-cycled bipolar and unipolar radiofrequency energy. Journal of Cardiovascular Electrophysiology, 21(4), 399–405.

    Article  PubMed  Google Scholar 

  26. Khaykin, Y., Skanes, A., Champagne, J., Themistoclakis, S., Gula, L., Rossillo, A., et al. (2009). A randomized controlled trial of the efficacy and safety of electroanatomic circumferential pulmonary vein ablation supplemented by ablation of complex fractionated atrial electrograms versus potential-guided pulmonary vein antrum isolation guided by intracardiac ultrasound. Circulation. Arrhythmia and Electrophysiology, 2(5), 481–487.

    Article  PubMed  Google Scholar 

  27. Calkins, H., Brugada, J., Packer, D. L., Cappato, R., Chen, S. A., Crijns, H. J., et al. (2007). HRS/EHRA/ECAS expert Consensus Statement on catheter and surgical ablation of atrial fibrillation: recommendations for personnel, policy, procedures and follow-up. A report of the Heart Rhythm Society (HRS) Task Force on catheter and surgical ablation of atrial fibrillation. Heart Rhythm, 4(6), 816–861.

    Article  PubMed  Google Scholar 

  28. Marrouche, N. F., Martin, D. O., Wazni, O., Gillinov, A. M., Klein, A., Bhargava, M., et al. (2003). Phased-array intracardiac echocardiography monitoring during pulmonary vein isolation in patients with atrial fibrillation. Impact on outcome and complications. Circulation, 107, 2710–2716.

    Article  PubMed  Google Scholar 

  29. Kilicaslan, F., Verma, A., Saad, E., Rossillo, A., Davis, D. A., Prasad, S. K., et al. (2006). Transcranial doppler detection of microembolic signals during pulmonary vein antrum isolation: Implications for titration of radiofrequency energy. Journal of Cardiovascular Electrophysiology, 17(5), 495–501.

    Article  PubMed  Google Scholar 

  30. Birnie, D., Healey, J. S., Krahn, A. D., Ahmad, K., Crystal, E., Khaykin, Y., et al. (2011). Prevalence and risk factors for cervical and lumbar spondylosis in interventional electrophysiologists. Journal of Cardiovascular Electrophysiology, 22(9), 957–960.

    Article  PubMed  Google Scholar 

  31. Bittner, A., Monnig, G., Zellerhoff, S., Pott, C., Kobe, J., Dechering, D., et al. (2011). Randomized study comparing duty-cycled bipolar and unipolar radiofrequency with point-by-point ablation in pulmonary vein isolation. Heart Rhythm, 8(9), 1383–1390.

    Article  PubMed  Google Scholar 

  32. Bulava, A., Hanis, J., Sitek, D., Osmera, O., Karpianus, D., Snorek, M., et al. (2010). Catheter ablation for paroxysmal atrial fibrillation: A randomized comparison between multielectrode catheter and point-by-point ablation. Pacing and Clinical Electrophysiology: PACE, 33(9), 1039–1046.

    Article  PubMed  Google Scholar 

  33. Tivig, C., Dang, L., Brunner-La Rocca, H. P., Ozcan, S., Duru, F., & Scharf, C. (2010). Duty-cycled unipolar/bipolar versus conventional radiofrequency ablation in paroxysmal and persistent atrial fibrillation. International journal of cardiology.

  34. Herrera Siklody, C., Deneke, T., Hocini, M., Lehrmann, H., Shin, D. I., Miyazaki, S., et al. (2011). Incidence of asymptomatic intracranial embolic events after pulmonary vein isolation: Comparison of different atrial fibrillation ablation technologies in a multicenter study. Journal of the American College of Cardiology, 58(7), 681–688.

    Article  PubMed  Google Scholar 

  35. Deneke, T., Shin, D. I., Balta, O., Bunz, K., Fassbender, F., Mugge, A., et al. (2011). Postablation asymptomatic cerebral lesions: Long-term follow-up using magnetic resonance imaging. Heart rhythm.

  36. Gaita, F., Leclercq, J. F., Schumacher, B., Scaglione, M., Toso, E., Halimi, F., et al. (2011). Incidence of silent cerebral thromboembolic lesions after atrial fibrillation ablation may change according to technology used: Comparison of irrigated radiofrequency, multipolar nonirrigated catheter and cryoballoon. Journal of Cardiovascular Electrophysiology, 22(9), 961–968.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yaariv Khaykin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Khaykin, Y., Zarnett, L., Friedlander, D. et al. Point-by-point pulmonary vein antrum isolation guided by intracardiac echocardiography and 3D mapping and duty-cycled multipolar AF ablation: effect of multipolar ablation on procedure duration and fluoroscopy time. J Interv Card Electrophysiol 34, 303–310 (2012). https://doi.org/10.1007/s10840-012-9676-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10840-012-9676-3

Keywords

Navigation